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Co-localization of hypocretin-1 and hypocretin-2 in the cat hypothalamus and brainstem
Peptides, 2002Hypocretin-1 (hcrt-1) and hypocretin-2 (hcrt-2) are two recently discovered hypothalamic neuropeptides. In the present study, using double immunofluorescent techniques, the co-localization of hcrt-1 and hcrt-2 was examined in neuronal soma and fibers/terminals located, respectively, in the cat hypothalamus and brainstem. In the hypothalamus, all hcrt-1
Jian-Hua, Zhang +3 more
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Reactive and predictive homeostasis: Roles of orexin/hypocretin neurons.
Neuropharmacology, 2019Homeostasis is the maintenance of a healthy physiological equilibrium in a changing world. Reactive (feedback, counter-regulatory) and predictive (feedforward, anticipatory) homeostatic control strategies are both important for survival.
D. Burdakov
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Orexins (Hypocretins) and Adrenal Function
Hormone and Metabolic Research, 2004The recently discovered neuropeptides orexin A and B regulate feeding behavior, neuroendocrine and autonomic functions, and sleep-wakefulness by central mechanisms. The expression of orexins and orexin receptors in various peripheral organs and the presence of orexin A in blood indicate the existence of a peripheral orexin system.
O, Jöhren, N, Brüggemann, P, Dominiak
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The Lancet Neurology, 2015
Since their discovery in 1998, the neurotransmitter peptides hypocretin 1, or orexin A, and hypocretin 2, or orexin B, have been implicated in several neuronal systems, including sleep and wake cycles, neuroendocrine and locomotor function, autonomic regulation, feeding behaviour and energy homoeostasis, and also in the pathophysiology of narcolepsy ...
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Since their discovery in 1998, the neurotransmitter peptides hypocretin 1, or orexin A, and hypocretin 2, or orexin B, have been implicated in several neuronal systems, including sleep and wake cycles, neuroendocrine and locomotor function, autonomic regulation, feeding behaviour and energy homoeostasis, and also in the pathophysiology of narcolepsy ...
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2015
The main topic of this book stems from the discovery of two neuropeptides derived from the same precursor, conducted in parallel by two different groups (de Lecea et al. in Proc Natl Acad Sci USA 95:322–327, 1998; Sakurai et al. in Cell 92:573–585, 1998).
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The main topic of this book stems from the discovery of two neuropeptides derived from the same precursor, conducted in parallel by two different groups (de Lecea et al. in Proc Natl Acad Sci USA 95:322–327, 1998; Sakurai et al. in Cell 92:573–585, 1998).
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The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
Nature Reviews Neuroscience, 2007T. Sakurai
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