Results 51 to 60 of about 767 (179)

Genetic Aspects of Adult-Type Hypolactasia

Journal of Gastrointestinal & Digestive System, 2016
Background and Objective: Lactose is a disaccharide sugar and is found in mammals milk and derivatives. Lactose intolerance is the inability to metabolize lactose, because of a lack of the required enzyme lactase in the digestive system. Genetically the physiological hypolactasia (primary LM) is associated with the LCT-13910 C/T and LCT-22018 G/A ...
DellEdera D, Nicoletti FP, D Apice MR, Allegretti A, Epifania AA   +4 more
openaire   +1 more source

Розповсюдження генетично детермінованої гіполактазії дорослого типу у хворих на муковісцидоз, гомозигот за мутацією p.Phe508del

Фактори експериментальної еволюції організмів, 2015
Aims. Adult-type hypolactasia (ATH) is the genetically determined most common cause of milk intolerance in children, adolescents and adults and the most common enzyme deficiency in humans.
М. Я. Тиркус, Г. В. Макух, Л. Й. Бобер, Н. В. Роговик, О. З. Гнатейко   +4 more
doaj  

Morphological method for the diagnosis of human adult type hypolactasia. [PDF]

Gut, 1994
The primary adult type hypolactasia is the most common form of genetically determined disaccharidase deficiency. This study examined a large and homogeneous population of the south of Italy: surgical biopsy specimens of proximal jejunum from 178 adult subjects have been assayed for disaccharidase activities; the expression of lactase protein and ...
MAIURI L, ROSSI M, RAIA, VALERIA, PAPARO F, COLETTA S, MAZZEO F, BREGLIA A, AURICCHIO S.   +7 more
openaire   +3 more sources

Single nucleotide polymorphism C/T-13910, located upstream of the lactase gene, associated with adult-type hypolactasia: Validation for clinical practice

, 2008
Objectives: To validate C/T-13910 polymorphism associated with primary hypolactasia for clinical practice. Design and methods: Lactose breath test and PCR-RFLP for the C/T-13910 polymorphism were performed.
CARRILHO, Flair Jose, MONTEIRO, Maria do Socorro, MATTAR, Rejane, SANTOS, Anibal Ferreira dos, VILLARES, Cibele Aparecida   +4 more
core   +1 more source

Noninvasive diagnosis of hypolactasia with 4-galactosylxylose (gaxilose): A multicentre, open-label, phase IIB-III nonrandomized trial

, 2014
et al.[Goals and Background]: Hypolactasia affects over half of the world population. Diagnosis remains problematic as currently available tests, such as the hydrogen breath test, have low reliability and lactose intolerance symptoms are unspecific.
Aragón, Juan J., Cano, Amparo, Martínez-Costa, Oscar H., Fernández-Mayoralas, Alfonso, Codoceo, Rosa, Sánchez, Valentina, Hermida, Carmen   +6 more
core   +1 more source

Rotavirus infection in children with different variants allelic polymorphism C> T 13910 gene LCT = Перебіг ротавірусної інфекції у дітей з різними варіантами алельного поліморфізму С >Т 13910 гена лактази

Journal of Education, Health and Sport, 2016
Nezgoda I., Naumenko O. Rotavirus infection in children with different variants allelic polymorphism C> T 13910 gene LCT = Перебіг ротавірусної інфекції у дітей з різними варіантами алельного поліморфізму С >Т 13910 гена лактази.
I. Nezgoda, O. Naumenko
doaj   +3 more sources

Host genetic variation and its microbiome interactions within the Human Microbiome Project

Genome Medicine, 2018
Background Despite the increasing recognition that microbial communities within the human body are linked to health, we have an incomplete understanding of the environmental and molecular interactions that shape the composition of these communities ...
Raivo Kolde, Eric A. Franzosa, Gholamali Rahnavard, Andrew Brantley Hall, Hera Vlamakis, Christine Stevens, Mark J. Daly, Ramnik J. Xavier, Curtis Huttenhower   +8 more
doaj   +1 more source

ROLE OF BREASTFEEDING IN PREVENTING LONG-TERM METABOLIC DISORDERS: REVIEW

Педиатрическая фармакология, 2015
The literature review is dedicated to the preventive role of breastfeeding in preserving long-term health of individuals and the population in whole.
I. A. Belyaeva, L. S. Namazova-Baranova, T. V. Turti, E. P. Bombardirova, M. D. Mitish, T. V. Potekhina   +5 more
doaj   +1 more source

The European lactase persistence genotype determines the lactase persistence state and correlates with gastrointestinal symptoms in the Hispanic and Amerindian Chilean population: a case–control and population-based study

BMJ Open, 2011
Background The lactase persistent (LP) or lactase non-persistent (LNP) state in European adults is genetically determined by a single nucleotide polymorphism (SNP) located 13.9 kb upstream of the lactase (LCT) gene, known as LCT C>T−13910 (rs4988235).
Juan Francisco Miquel, Eugenia Morales, Lorena Azocar, Ximena Maul, Claudio Perez, José Chianale   +5 more
doaj   +1 more source

Hypolactasia as a molecular basis of lactose intolerance

, 2006
267-274Lactase-phlorizin hydrolase (LPH), a membrane-bound glycoprotein present in the luminal surface of enterocytes in the intestine is responsible for lactose intolerance, a phenomenon prevalent in humans worldwide.
Mahmood, Safrun, Mahmood, Akhtar, Kaur, Kamaljit   +2 more
core