Results 1 to 10 of about 151,312 (311)

Hypothalamic–Pituitary Diseases and Erectile Dysfunction [PDF]

Journal of Clinical Medicine, 2021
Several hormones contribute to ensure penile erection, a neurovascular phenomenon in which nitric oxide plays a major role. Erectile dysfunction (ED), which is defined as the persistent inability to obtain or maintain penile erection sufficient for a satisfactory sexual performance, may be due to arteriogenic, neurogenic, iatrogenic, but also ...
Gianmaria Salvio, Marianna Martino, Giulia Giancola, Giorgio Arnaldi, Giancarlo Balercia   +4 more
openaire   +3 more sources

Expert Consensus on Bilateral Inferior Petrosal Sinus Sampling in the Diagnosis of Cushing′s Syndrome (2023)

罕见病研究, 2023
Cushing′s syndrome(CS)is a clinical syndrome caused by a variety of causes, with main manifestations exhibited by central obesity, purple skin striae, hypertension, and diabetes. In patients with adrenocorticotropic hormone(ACTH)-dependent CS, the result
Chinese Medical Association Rare Diseases Branch, Hypothalamic and Pituitary Disease Group of China Alliance of Rare Diseases (CARD), Innovation Center of Pituitary Diseases, Peking Union Medical College Hospital   +1 more
doaj   +1 more source

Adamantinomatous craniopharyngioma cyst fluid can trigger inflammatory activation of microglia to damage the hypothalamic neurons by inducing the production of β-amyloid

Journal of Neuroinflammation, 2022
Introduction The mechanism by which adamantinomatous craniopharyngioma (ACP) damages the hypothalamus is still unclear. Cyst fluid rich in lipids and inflammatory factors is a characteristic pathological manifestation of ACP and may play a very important
Yilamujiang Ainiwan, Yiguang Chen, Chaofu Mao, Junxiang Peng, Siyuan Chen, Songtao Wei, Songtao Qi, Jun Pan   +7 more
doaj   +1 more source

Roux-en-Y gastric bypass contributes to weight loss-independent improvement in hypothalamic inflammation and leptin sensitivity through gut-microglia-neuron-crosstalk

Molecular Metabolism, 2021
Objective: Hypothalamic inflammation and endoplasmic reticulum (ER) stress are extensively linked to leptin resistance and overnutrition-related diseases. Surgical intervention remains the most efficient long-term weight-loss strategy for morbid obesity,
Jiesi Chen, Nadine Haase, Sven-Bastiaan Haange, Robert Sucher, Julia Münzker, Elisabeth Jäger, Kristin Schischke, Florian Seyfried, Martin von Bergen, Mohammed K. Hankir, Ute Krügel, Wiebke K. Fenske   +11 more
doaj   +1 more source

Large-scale genome-wide association study to identify causal relationships and potential mediators between education and autoimmune diseases

Frontiers in Immunology, 2023
ObjectivesEpidemiological studies suggested a potential connection between education and autoimmune disorders. This study investigated the possible cause-and-effect relationship using a Mendelian randomization approach.MethodsWe explored the causality ...
Yingjie Li, Yingjie Li, Jingwei Zhang, Jingwei Zhang, Jingwei Zhang, Jie Wen, Jie Wen, Jie Wen, Mingren Liu, Mingren Liu, Mingren Liu, Wanyao Liu, Yongzhen Li   +12 more
doaj   +1 more source

Circadian Rhythms of the Hypothalamus: From Function to Physiology

Clocks & Sleep, 2021
The nearly ubiquitous expression of endogenous 24 h oscillations known as circadian rhythms regulate the timing of physiological functions in the body.
Rachel Van Drunen, Kristin Eckel-Mahan
doaj   +1 more source

Identification of Novel Hypothalamic MicroRNAs as Promising Therapeutics for SARS-CoV-2 by Regulating ACE2 and TMPRSS2 Expression: An In Silico Analysis

Brain Sciences, 2020
Background: Neuroinvasion of severe acute respiratory syndrome coronavirus (SARS-CoV) is well documented and, given the similarities between this virus and SARS-CoV-2, it seems that the neurological impairment that is associated with coronavirus disease ...
Debasmita Mukhopadhyay, Bashair M. Mussa
doaj   +1 more source

AI-assisted quantification of hypothalamic atrophy in amyotrophic lateral sclerosis by convolutional neural network-based automatic segmentation

Scientific Reports, 2023
The hypothalamus is a small structure of the brain with an essential role in metabolic homeostasis, sleep regulation, and body temperature control. Some neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and dementia syndromes are ...
Ina Vernikouskaya, Hans-Peter Müller, Francesco Roselli, Albert C. Ludolph, Jan Kassubek, Volker Rasche   +5 more
doaj   +1 more source

TRH: Pathophysiologic and clinical implications [PDF]

, 1985
Thyrotropin releasing hormone is thought to be a tonic stimulator of the pituitary TSH secretion regulating the setpoint of the thyrotrophs to the suppressive effect of thyroid hormones. The peptide stimulates the release of normal and elevated prolactin.
A. Enjalbert, A. H. Barnett, A. H. Tashjian, A. I. Faden, A. J. L. Clark, A. Mongioi, B. M. Arafah, C. Carr, C. Faglia, C. M. Feek, C. R. Pickardt, C. R. Pickardt, C. R. Pickardt, C. R. Pickardt, C. R. Pickardt, C. R. Pickardt, D. Evain-Brion, D. S. Cooper, E. Flückiger, E. Hefco, E. Montoya, E. Roti, F. Guignier, F. Labrie, F. Massara, G. E. Shambaugh III, G. F. F. Pieters, G. Faglia, G. Faglia, G. Faglia, G. Faglia, G. Faglia, G. N. Burrow, G. P. Ceda, H. J. Chen, H. M. Fraser, J. B. Martin, J. F. Wilber, J. Habermann, J. J. Staub, J. Klindt, J. Köbberling, J. R. Sowers, J. R. Sowers, J. Sack, J.-N. Hugues, K. Hiramatsu, K. Horn, K. O. Nillson, K. W. Wenzel, K. Werder von, L. S. Jacobs, L. Wartofsky, L. Ø. Dolva, L. Ø. Dolva, L. Ø. Dolva, M. F. Scanlon, M. F. Scanlon, M. F. Scanlon, M. L'Hermite, M. M. Rabello, M. Otsuki, M. Szabo, O. Benkert, P. C. Scriba, P. C. Scriba, P. C. Scriba, P. J. Snyder, R. A. Maurer, R. Hall, R. M. Lechan, S. Ahuja, S. F. Kuku, S. Refetoff, S. Urman, St. M. Foord, T. K. Mallik, T. Mitsuma, V. B. Petersen, W. E. Cobb, W. K. Engel, W. Vale, Y. Koch   +82 more
core   +1 more source

Diurnal fluctuation in the number of hypocretin/orexin and histamine producing: Implication for understanding and treating neuronal loss. [PDF]

, 2017
The loss of specific neuronal phenotypes, as determined by immunohistochemistry, has become a powerful tool for identifying the nature and cause of neurological diseases. Here we show that the number of neurons identified and quantified using this method
McGregor, Ronald, Shan, Ling, Siegel, Jerome M, Wu, Ming-Fung   +3 more
core   +10 more sources