Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure [PDF]
Advanced ScienceParticulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear.
Chenxu Ge +21 more
doaj +2 more sources
Inflammation and vasopressin hypersecretion in aging [PDF]
Frontiers in EndocrinologyLow-grade inflammation, both hypothalamic and systemic, sensitizes the neuroendocrine response to osmotic stimuli whose proximate cause is chronic underhydration common in older adults due to diminished thirst perception.
Kerim Mutig +4 more
doaj +2 more sources
Emerging role of hypothalamus in the metabolic regulation in the offspring of maternal obesity
Frontiers in Nutrition, 2023 Maternal obesity has a significant impact on the metabolism of offspring both in childhood and adulthood. The metabolic regulation of offspring is influenced by the intrauterine metabolic programming induced by maternal obesity. Nevertheless, the precise
Jingyi Zhang +3 more
doaj +1 more source
AMPK in the central nervous system: physiological roles and pathological implications [PDF]
, 2016 5′ AMP-activated protein kinase (AMPK) is considered the master metabolic regulator in all eukaryotes, as it maintains cellular energy homeostasis in a variety of tissues, including the brain.
Fioramonti, Marco +6 more
core +1 more source
Adipocyte Gs but not Gi signaling regulates whole-body glucose homeostasis
Molecular Metabolism, 2019 Objective: The sympathetic nervous system (SNS) is a key regulator of the metabolic and endocrine functions of adipose tissue. Increased SNS outflow promotes fat mobilization, stimulates non-shivering thermogenesis, promotes browning, and inhibits leptin
Alexandre Caron +8 more
doaj +1 more source
The spleen: a hub connecting nervous and immune systems in cardiovascular and metabolic diseases [PDF]
, 2017 Metabolic disorders have been identified as major health problems affecting a large portion of the world population. In addition, obesity and insulin resistance are principal risk factors for the development of cardiovascular diseases.
Carnevale, Daniela +3 more
core +2 more sources
Night-time shift work and related stress responses: A study on security guards [PDF]
, 2020 Work-related stress can induce a break in homeostasis by placing demands on the body that are met by the activation of two different systems, the hypothalamic\u2013pituitary\u2013adrenal axis and the sympathetic nervous system.
Cannizzaro E. +7 more
core +1 more source
Molecular Metabolism, 2019 Background: The prevalence of obesity and metabolic diseases continues to rise globally. The increased consumption of unhealthy energy-rich diets that are high in fat and sugars results in oxidative stress and inflammation leading to hypothalamic ...
Ebrahim Samodien +6 more
doaj +1 more source
Cancer anorexia: hypothalamic activity and its association with inflammation and appetite-regulating peptides in lung cancer [PDF]
, 2017 Background Energy homeostasis is mediated by the hypothalamus, whose inflammation-induced functional derangements contribute to the onset of anorexia in cancer.
Arezzo di Trifiletti +39 more
core +1 more source
From obesity resistance to obesity prediction and prevention? [PDF]
, 2016 Comment on: Regulation of hypothalamic neuropeptides gene expression in diet induced obesity resistant rats: possible targets for obesity prediction?
Cassano, Tommaso, Gaetani, Silvana
core +4 more sources