Results 51 to 60 of about 245,222 (354)

Assessment of the role of intracranial hypertension and stress on hippocampal cell apoptosis and hypothalamic-pituitary dysfunction after TBI

Scientific Reports, 2017
In recent years, hypopituitarism caused by traumatic brain injury (TBI) has been explored in many clinical studies; however, few studies have focused on intracranial hypertension and stress caused by TBI. In this study, an intracranial hypertension model,
Huajun Tan, Weijian Yang, Chenggang Wu, Baolong Liu, Hao Lu, Hong Wang, Hua Yan   +6 more
doaj   +1 more source

Hypoxia Inducible Factor as a Central Regulator of Metabolism – Implications for the Development of Obesity

Frontiers in Neuroscience, 2018
The hypothalamus plays a major role in the regulation of food intake and energy expenditure. In the last decade, it was demonstrated that consumption of high-fat diets triggers the activation of an inflammatory process in the hypothalamus, inducing ...
Joana M. Gaspar, Joana M. Gaspar, Lício A. Velloso, Lício A. Velloso   +3 more
doaj   +1 more source

Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression

eLife, 2021
While recent studies have uncovered dedicated neural pathways mediating the positive control of parenting, the regulation of infant-directed aggression and how it relates to adult-adult aggression is poorly understood. Here we show that urocortin-3 (Ucn3)
Anita E Autry, Zheng Wu, Vikrant Kapoor, Johannes Kohl, Dhananjay Bambah-Mukku, Nimrod D Rubinstein, Brenda Marin-Rodriguez, Ilaria Carta, Victoria Sedwick, Ming Tang, Catherine Dulac   +10 more
doaj   +1 more source

Function of the hypothalamus

The American Journal of Medicine, 1967
Seymour Reichlin
openalex   +4 more sources

Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation

Journal of Neuroinflammation, 2017
BackgroundThe consumption of large amounts of dietary fats is one of the most important environmental factors contributing to the development of obesity and metabolic disorders.
N. Dragano, C. Solon, Albina F. Ramalho, R. F. de Moura, D. Razolli, E. Christiansen, Carlos M. G. Azevedo, T. Ulven, L. Velloso   +8 more
semanticscholar   +1 more source

Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone‐Glucocorticoid Receptor‐LAMA5 Axis

Advanced Science, EarlyView.
In vivo experiments suggest that cardiomyocyte hypertrophy is an early manifestation of cardiac pathological changes induced by chronic psychological stress. In vivo and in vitro experiments suggest that the corticosterone‐glucocorticoid receptor‐LAMA5 axis mediates cardiomyocyte hypertrophy induced by chronic psychological stress. The clinical results
Chuanjing Zhang, Yongfei Song, Xiaojun Jin, Qingbo Xu, Honghua Ye, Zhuonan Wu, Hui Lin, Jiale Hu, Chen Huang, Jianqing Zhou, Jiangfang Lian   +10 more
wiley   +1 more source

Investigating the relationship between hippocampus/dentate gyrus volume and hypothalamus metabolism in participants with major depressive disorder

Scientific Reports
Reduced hippocampal volume occurs in major depressive disorder (MDD), potentially due to elevated glucocorticoids from an overactivated hypothalamus–pituitary–adrenal (HPA) axis.
Karen Lin, Daniel Sunko, Junying Wang, Jie Yang, Ramin V. Parsey, Christine DeLorenzo   +5 more
doaj   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Regional response to light illuminance across the human hypothalamus

eLife
Light exerts multiple non-image-forming biological effects on physiology including the stimulation of alertness and cognition. However, the subcortical circuitry underlying the stimulating impact of light is not established in humans.
Islay Campbell, Roya Sharifpour, Jose Fermin Balda Aizpurua, Elise Beckers, Ilenia Paparella, Alexandre Berger, Ekaterina Koshmanova, Nasrin Mortazavi, John Read, Mikhail Zubkov, Puneet Talwar, Fabienne Collette, Siya Sherif, Christophe Phillips, Laurent Lamalle, Gilles Vandewalle   +15 more
doaj   +1 more source

Hypothalamic Alterations in Neurodegenerative Diseases and Their Relation to Abnormal Energy Metabolism

Frontiers in Molecular Neuroscience, 2018
Neurodegenerative diseases (NDDs) are disorders characterized by progressive deterioration of brain structure and function. Selective neuronal populations are affected leading to symptoms which are prominently motor in amyotrophic lateral sclerosis (ALS)
Pauline Vercruysse, Pauline Vercruysse, Pauline Vercruysse, Didier Vieau, David Blum, Åsa Petersén, Luc Dupuis, Luc Dupuis   +7 more
doaj   +1 more source