Results 41 to 50 of about 92,945 (337)

Didanosine determination in diluted alkaline electrolyte by adsorptive stripping voltammetry at the mercury film electrode [PDF]

Journal of Electrochemical Science and Engineering, 2012
A stripping method for the determination of didanosine at the submicromolar concentration levels is described. The method is based on controlled adsorptive accumulation of didanosine at thin-film mercury electrode followed by a linear cyclic scan ...
PERCIO AUGUSTO MARDINI FARIAS, ARNALDO AGUIAR CASTRO, ANA ISA PEREZ CORDOVES   +2 more
doaj  

Detection of Hypoxanthine from Inosine and Unusual Hydrolysis of Immunosuppressive Drug Azathioprine through the Formation of a Diruthenium(III) System

Biosensors, 2021
Hypoxanthine (hpx) is an important molecule for both biochemistry research and biomedical applications. It is involved in several biological processes associated to energy and purine metabolism and has been proposed as a biomarker for a variety of ...
Marta Orts-Arroyo, Isabel Castro, José Martínez-Lillo   +2 more
doaj   +1 more source

Lactobacillus gasseri PA-3 Uses the Purines IMP, Inosine and Hypoxanthine and Reduces Their Absorption in Rats

Microorganisms, 2017
Excessive intake of purine-rich foods elevates serum levels of uric acid. Animal and fish meats contain high amounts of inosine and its related purines, and the reduction of taking those purines is crucial for the improvement of serum uric acid levels ...
N. Yamada, Chizuru Saito-Iwamoto, Marie Nakamura, Misato Soeda, Yoshika Chiba, H. Kano, Y. Asami   +6 more
semanticscholar   +1 more source

Hypoxanthine as a Measurement of Hypoxia [PDF]

Pediatric Research, 1975
The hypoxanthine concentration in plasma was found to be a sensitive parameter of hypoxia of the fetus and the newborn infant. The plasma level of hypoxanthine in the umbilical cord in 29 newborn infants with normal delivery varied between 0 and 11.0 mumol/liter with a mean of 5.8 mumol/liter, SD 3.0 mumol/liter.
openaire   +2 more sources

Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine [PDF]

, 2012
Background: Purine nucleotides exhibit various functions in cellular metabolism. Besides serving as building blocks for nucleic acid synthesis, they participate in signaling pathways and energy metabolism.
Barduhn, Tobias, Heinzle, Elmar, Peifer, Susanne, Schneider, Konstantin, Volmer, Dietrich A., Zimmet, Sarah   +5 more
core   +1 more source

Hypoxanthine induces cholesterol accumulation and incites atherosclerosis in apolipoprotein E‐deficient mice and cells

Journal of Cellular and Molecular Medicine, 2016
Reactive oxygen species (ROS) generation during purine metabolism is associated with xanthine oxidase and uric acid. However, the direct effect of hypoxanthine on ROS generation and atherosclerosis has not been evaluated.
H. Ryu, You-Jin Kim, E. Oh, Se-Hyun Oh, Ji-Young Choi, Jang-Hee Cho, Chan-Duck Kim, Sun-Hee Park, Yong-Lim Kim   +8 more
semanticscholar   +1 more source

Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells. [PDF]

, 2014
BACKGROUND: The importance of the genetic background of cancer cells for the individual susceptibility to cancer treatments is increasingly apparent.
Arozarena, Imanol, Erice, O., Ferguson, J., Goicoechea, I., Margison, G.P., Wellbrock, C.   +5 more
core   +2 more sources

Hypoxanthine Induces Muscular ATP Depletion and Fatigue via UCP2

Frontiers in Physiology, 2021
Hypoxanthine (Hx), an intermediate metabolite of the purine metabolism pathway which is dramatically increased in blood and skeletal muscle during muscle contraction and metabolism, is characterized as a marker of exercise exhaustion.
Cong Yin, Zewei Ma, Fan Li, Chen Duan, Yexian Yuan, Canjun Zhu, Lina Wang, Xiaotong Zhu, Songbo Wang, Ping Gao, Gang Shu, Huihua Zhang, Qingyan Jiang   +12 more
doaj   +1 more source

Mouse versus Rat: Profound Differences in Meiotic Regulation at the Level of the Isolated Oocyte [PDF]

, 2011
Cumulus cell-enclosed oocytes (CEO), denuded oocytes (DO), or dissected follicles were obtained 44–48 hr after priming immature mice (20–23 days old) with 5 IU or immature rats (25–27 days old) with 12.5 IU of equine chorionic gonadotropin, and exposed ...
Biggers, Brannstrom, Chen, Chen, Cho, Dekel, Dekel, Dekel, Dekel, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Eppig, Fagbohun, Fagbohun, Han, Hubbard, LaRosa, LaRosa, Larsen, Magnusson, Makris, Masciarelli, Mouse Genome Sequencing Consortium, Mullins, Norris, Norris, Norris, Racowsky, Rat Genome Sequencing Project Consortium, Ratner, Ratner, Reizel, Richard, Romero, Schultz, Sela-Abramovich, Sela-Abramovich, Sela-Abramovich, Shitsukawa, Tornell, Tornell, Tornell, Tornell, Tornell, Tsafriri, Tsafriri, Vaccari, Vivarelli, Zeilmaker, Zhang, Zhang, Zhang, Zhao   +61 more
core   +2 more sources

The Iron–Sulfur Cluster of Bacterioferritin‐Associated Ferredoxin (Bfd): a “Biological Fuse” that Prevents Oxidative Damage to Cells?

Angewandte Chemie, EarlyView.
When cellular iron is low, bacterioferritin (Bfr) releases its stored iron through a reductive process dependent on the [2Fe–2S] ferredoxin Bfd. Why accessing stored iron should depend on an iron‐requiring protein when iron is scarce is unclear. Here, we show that the Bfd [2Fe–2S] cluster is sensitive to oxidative stress, suggesting that it may act as ...
Justin M. Bradley, Aiden M. Carter, Zinnia Bugg, Simon C. Andrews, Nick E. Le Brun   +4 more
wiley   +2 more sources