Results 51 to 60 of about 103,245 (286)

Application of Liquid Chromatography Coupled to Mass Spectrometry for Direct Estimation of the Total Levels of Adenosine and Its Catabolites in Human Blood

Pharmaceuticals
Adenosine is a multifunctional nucleoside with several roles across various levels in organisms. Beyond its intracellular involvement in cellular metabolism, extracellular adenosine potently influences both physiological and pathological processes.
Jakub Šofranko, Peter Mitro, Zora Lazúrová, Martin Jozef Péč, Tomáš Bolek, Renata Péčová, Matúš Dohál, Matej Samoš, Radovan Murín   +8 more
doaj   +1 more source

Integrative Analysis of Metabolomics and Transcriptomics Data Identifies Prognostic Biomarkers Associated With Oral Squamous Cell Carcinoma

Frontiers in Oncology, 2021
BackgroundOral squamous cell carcinoma (OSCC) is the most malignant neoplasm in oral cancer. There is growing evidence that its progression involves altered metabolism.
Lihua Zuo, Zhuo Chen, Lihuang Chen, Jian Kang, Yingying Shi, Liwei Liu, Shuhua Zhang, Qingquan Jia, Yi Huang, Zhi Sun   +9 more
doaj   +1 more source

Regulation of the G2/M Transition in Rodent Oocytes [PDF]

, 2010
Regulation of maturation in meiotically competent mammalian oocytes is a complex process involving the carefully coordinated exchange of signals between the somatic and germ cell compartments of the ovarian follicle via paracrine and cell–cell coupling ...
Downs, Stephen
core   +2 more sources

Advancing Clinical Medicine with Raman Spectroscopy: Current Trends and Future Perspectives

Advanced Photonics Research, EarlyView.
Raman spectroscopy and microscopy may become excellent tools in clinical medicine, including hematology, oncology, infectious diseases, neurology, gastroenterology, reproductive medicine, rheumatology, and cardiovascular research. However, many challenges such as signal interference, standardization issues, and limited clinical application need to be ...
Jiří Bufka, Lenka Vaňková, Josef Sýkora, Věra Křížková, Jan Schwarz, Petr Bouř   +5 more
wiley   +1 more source

Repair of Hypoxanthine in DNA Revealed by DNA Glycosylases and Endonucleases From Hyperthermophilic Archaea

Frontiers in Microbiology, 2021
Since hyperthermophilic Archaea (HA) thrive in high-temperature environments, which accelerate the rates of deamination of base in DNA, their genomic stability is facing a severe challenge.
Tan Lin, Likui Zhang, Likui Zhang, Mai Wu, Donghao Jiang, Zheng Li, Zhihui Yang   +6 more
doaj   +1 more source

Taxonomy and chemical characterization of new antibiotics produced by Saccharothrix SA198 isolated from a Saharan soil [PDF]

, 2013
Actinomycete strain SA198, isolated from a Saharan soil sample of Algeria, exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria, and phytopathogenic and toxinogenic fungi.
A. Lebrihi, A. Zitouni, Andriole, Becker, Berdy, Betina, Buckingham, Bull, Bush, Bycroft, C. Bijani, D. Boubetra, F. Mathieu, Felsenstein, Felsenstein, Genilloud, Hayakawa, Hayakawa, Hosoe, Igarashi, Kalinovskaya, Kelly, Kim, Kimura, Kinochita, Labeda, Lamari, Lass-Flörl, Lazzarini, Lechevalier, Lechevalier, Liu, Locci, Merrouche, Minnikin, Murakami, N. Sabaou, Oki, Sabaou, Sanglier, Shirling, Singh, Stackebrandt, Suzuki, Takahashi, Takeuchi, Tamura, Thompson, Waksman, Wang, Zitouni, Zitouni, Zitouni   +52 more
core   +3 more sources

Biocatalytic Construction of a Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Nucleoside Probe: Synthesis and Evaluation of 5‐Methyl‐5,6‐Dihydrothymidine

Advanced Synthesis &Catalysis, EarlyView.
Al‐Hilfi et al. present a biocatalytic strategy for synthesizing 5‐methyl‐5,6‐dihydrothymidine (5‐MDHT), a sensitive MRI contrast agent. The study demonstrates that recombinant enzyme catalysis offers an efficient, sustainable, and eco‐friendly alternative to traditional chemical synthesis for producing clinically relevant imaging probes.
Aimen Al‐Hilfi, E. Alejandro Castellanos Franco, Connor J. Grady, Zinia Mohanta, Michael T. McMahon, Milana Bazayeva, Zhen Li, Kenneth M. Merz Jr., Assaf A. Gilad   +8 more
wiley   +1 more source

High-Intensity Interval Training Decreases Resting Urinary Hypoxanthine Concentration in Young Active Men—A Metabolomic Approach

Metabolites, 2019
High-intensity interval training (HIIT) is known to improve performance and skeletal muscle energy metabolism. However, whether the body’s adaptation to an exhausting short-term HIIT is reflected in the resting human metabolome has not been ...
Sina Kistner, Manuela J. Rist, Ralf Krüger, Maik Döring, Sascha Schlechtweg, Achim Bub   +5 more
doaj   +1 more source

Fast Protein and Metabolites (Nucleotides and Nucleosides) Liquid Chromatography Technique and Chemical Sensor for the Assessment of Fish and Meat Freshness

Chemosensors, 2023
Fast protein and metabolite liquid chromatography (FPLMC) was introduced years ago to enable the easy separation of high-molecular compounds such as proteins from small molecules and the identification of the low-molecular substances.
Artur Kuznetsov, Aleksandr Frorip, Alar Sünter, Nensi Kasvand, Vadim Korsakov, Georgii Konoplev, Oksana Stepanova, Linda Rusalepp, Dea Anton, Tõnu Püssa, Mati Roasto, Liubov Abramova, Andrey Kozin, Lauri Toom, Soeren Hirsch, Nikolay Mukhin   +15 more
doaj   +1 more source

Upregulation of inducible NO synthase by exogenous adenosine in vascular smooth muscle cells activated by inflammatory stimuli in experimental diabetes [PDF]

, 2016
BACKGROUND: Adenosine has been shown to induce nitric oxide (NO) production via inducible NO synthase (iNOS) activation in vascular smooth muscle cells (VSMCs). Although this is interpreted as a beneficial vasodilating pathway in vaso-occlusive disorders,
Cignarella, Andrea, Gaion, ROSA MARIA, Malorgio, Francesca, Nassi, Alberto, Tedesco, Serena   +4 more
core   +2 more sources