Results 71 to 80 of about 92,945 (337)

Unraveling the benefits of Bacillus subtilis DSM 29784 poultry probiotic through its secreted metabolites: an in vitro approach

Microbiology Spectrum
The probiotic Bacillus subtilis 29784 (Bs29784) sustains chicken’s intestinal health, enhancing animal resilience and performance through the production of the bioactive metabolites hypoxanthine (HPX), niacin (NIA), and pantothenate (PTH).
Nuria Vieco-Saiz, Damien P. Prévéraud, Eric Pinloche, Aurélien Morat, Pauline Govindin, Hervé M. Blottière, Elliot Matthieu, Estelle Devillard, Jessika Consuegra   +8 more
doaj   +1 more source

Plasma level of hypoxanthine/xanthine as markers of oxidative stress with different stages of obstructive sleep apnea syndrome

Annals of Saudi Medicine, 2014
BACKGROUND AND OBJECTIVES Tissue hypoxia due to repeated apneas among patients of obstructive sleep apnea syndrome (OSAS) leads to cumulative oxidative stress.
H. Hira, P. Samal, A. Kaur, S. Kapoor
semanticscholar   +1 more source

The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony [PDF]

, 2010
A role for the Plasmodium falciparum cyclic GMP (cGMP)-dependent protein kinase (PfPKG) in gametogenesis in the malaria parasite was elucidated previously. In the present study we examined the role of PfPKG in the asexual blood-stage of the parasite life
Baker, D.A., Dluzewski, A.R., Grainger, M., Holder, A.A., Hopp, C.S., McRobert, L., Sicard, A., Taylor, H.M.   +7 more
core   +1 more source

Targeted Intervention Strategies for Maternal–Offspring Transmission of Christensenellaceae in Pigs via a Deep Learning Model

Advanced Science, EarlyView.
This study deciphers maternal‐driven microbial transmission in pigs using a deep learning model (maternal–offspring microbial transmission model), identifying Christensenellaceae R‐7 group as a key transmitted taxon. Filtered galacto‐oligosaccharides‐targeted Christensenellaceae R‐7 group alters offspring microbial functions via maternal ...
Haibo Shen, Xiaokang Ma, Longlin Zhang, Hao Li, Jichang Zheng, Shengru Wu, Ke Zuo, Yulong Yin, Jing Wang, Bie Tan   +9 more
wiley   +1 more source

Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing [PDF]

, 2011
MicroRNAs (miRNAs) are prevalent regulatory RNAs that mediate gene silencing and play key roles in diverse cellular processes. While synthetic RNA-based regulatory systems that integrate regulatory and sensing functions have been demonstrated, the lack ...
Aagaard, An, Ballarino, Bartlett, Bauer, Bayer, Beisel, Beisel, Berens, Boudreau, Cai, Chase L. Beisel, Chen, Christina D. Smolke, Desai, Dickins, Friedman, Gregory, Grimm, Guil, Han, Han, Han, Hermann, Jenison, Kedde, Kevin G. Hoff, Kiga, Koizumi, Kumar, Lee, Lee, Lee, McBride, Muller, Osborne, Sinha, Stephanie J. Culler, Stern, Stoltenburg, Suess, Sun, Tuerk, Tuleuova, Wang, Wang, Weigand, Wieland, Wilson, Win, Win, Wiznerowicz, Xia, Yvonne Y. Chen, Zeng, Zeng, Zeng, Zeng, Zhang, Zhang   +59 more
core   +8 more sources

Translation of a Human‐Based Malaria‐on‐a‐Chip Phenotypic Disease Model for In Vivo Applications

Advanced Science, EarlyView.
Inoculation of the Malaria‐on‐a‐Chip model with human erythrocytes infected with Plasmodium falciparum can support the entire intraerythrocytic lifecycle for 7 days in vitro. Utilizing this human‐based, serum‐free model provides an alternative to animal testing by introducing a human‐based, preclinical alternative for antimalarial therapeutic delivery.
Michael J. Rupar, Hannah M. Hanson, Brianna L. Botlick, Narasimhan Sriram, Stephanie Rogers, Justin Zuniga, Zhanhe Liu, Steven J. Trimmer, Joseph M. Ciurca, Christopher J. Long, Christopher W. McAleer, Stephan Schmidt, Paola Favuzza, Philip Lowe, Nathalie Gobeau, James J. Hickman   +15 more
wiley   +1 more source

A monoclinic polymorph of hypoxanthine

Acta Crystallographica Section E Structure Reports Online, 2007
A monoclinic polymorph of hypoxanthine (systematic name: 1,7-dihydro-6H-purin-6-one), C5H4N4O, is reported. The hydrogen-bonding motifs involve a layered structure of N—H⋯O and N—H⋯N hydrogen-bonded mol­ecules. The mean stacking distance between adjacent layers is 3.672 A.
Rui-Qing Yang, Yong-Rong Xie
openaire   +2 more sources

Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress [PDF]

, 2009
Oxidative stress plays an important role in the progression of vascular endothelial dysfunction. The two major systems generating vascular oxidative stress are the NADPH oxidase and the xanthine oxidase pathways. Allopurinol, a xanthine oxidase inhibitor,
George, Jacob, Struthers, Allan D.
core   +3 more sources

Hypoxanthine Derivatives in Experimental Infections [PDF]

Canadian Journal of Infectious Diseases and Medical Microbiology, 1992
In vivo treatment with parenterally administered hypoxanthine derivatives, notably ST 789, was able to protect cyclophosphamide‐immunosuppressed mice against experimental infections with both bacterial and fungal pathogens. However, the mechanisms accounting for these effects of hypoxanthine derivatives remain to be fully established. In fact, only the
G. Tonietti, Claudio De Simone, Edoardo Arrigoni Martelli, Roberto Giacomelli, P. Foresta, Vito Ruggiero, Giuseppe Famularo, Emilio Jirillo   +7 more
openaire   +2 more sources

Molybdenum cofactor (chlorate-resistant) mutants of Klebsiella pneumoniae M5al can use hypoxanthine as the sole nitrogen source. [PDF]

, 1992
Selection for chlorate resistance yields mol (formerly chl) mutants with defects in molybdenum cofactor synthesis. Complementation and genetic mapping analyses indicated that the Klebsiella pneumoniae mol genes are functionally homologous to those of ...
Casadesús Pursals, Josep, Flores Díaz, Amando, Garzón, Andrés   +2 more
core