Results 51 to 60 of about 9,789 (207)

A Rapid and Specific Method for Separation of Bound and Free Antigen in Radioimmunoassay Systems [PDF]

, 1979
Peer ...
Müller, O. A., Scriba, Peter Christian, Stalla, G., Wood, W. G.   +3 more
core   +2 more sources

Purification and Characterization of Human Hypoxanthine/Guanine Phosphoribosyltransferase [PDF]

European Journal of Biochemistry, 1977
Human hypoxanthine/guanine phosphoribosyltransferase (EC 2.4.2.8) was purified from red blood cells by the following two methods. Method A includes (a) elimination of hemoglobin by DEAE‐cellulose, (b) DEAE‐Sephadex chromatography, (c) specific elution of the enzyme from CM‐Sephadex by pyrophosphate and (d) Sephadex G‐100 gel filtration.
Helmut Muensch, Akira Yoshida
openaire   +3 more sources

Anatomical Distribution of Nucleoside System in the Human Brain and Implications for Therapy [PDF]

, 2013
Nucleosides have a wide range of physiological and pathophysiological roles in the human brain as modulators of a variety of neural functions. For example, adenosine, inosine, guanosine, and uridine participate in the mechanisms underlying memory ...
Dobolyi, Árpád, Kovács, Zsolt
core   +1 more source

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

Advanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich, Jing Wang, Ferdinand Althammer, Tim Schubert, Nina Kluck, Valery Grinevich, Stefanie Schmitteckert, Christian P. Schaaf, Gudrun A. Rappold   +8 more
wiley   +1 more source

Converting the Guanine Phosphoribosyltransferase from Giardia lamblia to a Hypoxanthine-guanine Phosphoribosyltransferase [PDF]

Journal of Biological Chemistry, 2000
Guanine phosphoribosyltransferase from Giardia lamblia, a key enzyme in the purine salvage pathway, is a potential target for anti-giardiasis chemotherapy. Recent structural determination of GPRTase (Shi, W., Munagala, N. R., Wang, C. C., Li, C. M., Tyler, P. C., Furneaux, R. H., Grubmeyer, C., Schramm, V. L., and Almo, S. C.
Narsimha R. Munagala, Ching C. Wang, Anne E. Sarver   +2 more
openaire   +3 more sources

Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation [PDF]

, 2016
Objective: Transient receptor potential canonical 5 (TRPC5) is functionally expressed on a range of cells including fibroblast-like synoviocytes, which play an important role in arthritis. A role for TRPC5 in inflammation has not been previously shown in
Aisah A Aubdool, Aletaha, Alfieri, Ashraf, Ashraf, Aubdool, Bon, Bottini, Clapham, David A Walsh, Elizabeth S Fernandes, Feldmann, Fernandes, Fiona A Russell, Holt, Kasama, Katsikis, Keeble, Khadija M Alawi, Kinne, Kinne, Konttinen, Lindblad, Lineu Baldissera, McDougall, McDougall, Miller, Nurjahan Saleque, Olsen, Ostergaard, Ozgocmen, Pratish Thakore, Qvistgaard, Raza, Riccio, Russell, Salil Srivastava, Schaldecker, Shenker, Staaf, Stoppiello, Susan D Brain, Vandewauw, Wallis, Walsh, Walther, Williams, Wipke, Wright, Xu, Yanira Riffo-Vasquez, Yeo, Yoshihara   +52 more
core   +3 more sources

Late diagnosis of Lesch–Nyhan disease complicated with end-stage renal disease and tophi burst: a case report

Renal Failure, 2020
Background Lesch–Nyhan disease (LND) is a rare X-linked recessive inborn error of purine metabolism. Late diagnosis of LND may cause significant morbidity. LND cases have never been reported in Indonesia.
Cahyani Gita Ambarsari, Daffodilone Cahyadi, Lenny Sari, Oryza Satria, Felly Sahli, Thyrza Laudamy Darmadi, Agustina Kadaristiana   +6 more
doaj   +1 more source

The fate of thiopurine metabolites after switching to low‐dose thiopurine with allopurinol or thioguanine in IBD patients: A retrospective analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Shunting (hypermethylating) thiopurine metabolism, characterized by excessive 6‐MMPR production and (sub)therapeutic 6‐TGN levels, poses a significant challenge in the treatment of inflammatory bowel disease (IBD). This study evaluates the metabolic outcomes of switching to low‐dose thiopurine with allopurinol (LDTA) or thioguanine (TG) in IBD ...
Ahmed B. Bayoumy, Hedwig M. A. D'Agnolo, Nanne K. H. de Boer, Chris J. J. Mulder, Luc J. J. Derijks   +4 more
wiley   +1 more source

Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4 [PDF]

, 2013
Purpose: Bone defects and nonunions are major clinical skeletal problems. Growth factors are commonly used to promote bone regeneration; however, the clinical impact is limited because the factors do not last long at a given site.
Ito, Yoshihiro, Kitajima, Takashi, Matsukawa, Akihiro, Mazaki, Tetsuro, Nakamura, Mariko, Ozaki, Toshifumi, Shiozaki, Yasuyuki, Tanaka, Masato, Umezawa, Akihiro, Yoshida, Aki, Yoshida, Yasuhiro   +10 more
core   +1 more source

Uric Acid‐Lowering and Anti‐Hyperuricemia Effects of Plant‐Based Nutraceuticals and Foods: A Review

Food Chemistry International, EarlyView.
Increased UA production and/or decreased UA secretion cause hyperuricemia. Effects and mechanism of flavonoids in reducing UA are summarized. Terpenoids, saponins, alkaloids, vitamin C, polysaccharides, peptides are effective. Plant‐based foods with UA‐lowering ability are reviewed.
Linwei He, Wenjian Yang, Jianhui Liu
wiley   +1 more source