Results 71 to 80 of about 51,129 (240)

Elevated cortisol concentration in preterm sheep fetuses impacts heart development

Experimental Physiology, EarlyView.
Abstract The prepartum rise in cortisol promotes cardiac development and maturation. Here, we investigated the impact of elevated circulating cortisol during mid‐late gestation on cardiac growth and metabolism in fetal sheep. Saline or cortisol (2–3 mg in 4.4 mL/24 h) was infused into the fetal jugular vein from 109 to 116 days gestation (dG, term ...
Reza Amanollahi, Stacey L. Holman, Melanie R. Bertossa, Ashley S. Meakin, Vicki L. Clifton, Kent L. Thornburg, I. Caroline McMillen, Michael D. Wiese, Mitchell C. Lock, Janna L. Morrison   +9 more
wiley   +1 more source

Oleanolic acid blocks the purine salvage pathway for cancer therapy by inactivating SOD1 and stimulating lysosomal proteolysis

Molecular Therapy: Oncolytics, 2021
Metabolic reprogramming is a core hallmark of cancer and is key for tumorigenesis and tumor progression. Investigation of metabolic perturbation by anti-cancer compounds would allow a thorough understanding of the underlying mechanisms of these agents ...
Dan Liu, Xing Jin, Guanzhen Yu, Mingsong Wang, Lei Liu, Wenjuan Zhang, Jia Wu, Fengying Wang, Jing Yang, Qin Luo, Lili Cai, Xi Yang, Xisong Ke, Yi Qu, Zhenye Xu, Lijun Jia, Wen-Lian Chen   +16 more
doaj   +1 more source

Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4 [PDF]

, 2013
Purpose: Bone defects and nonunions are major clinical skeletal problems. Growth factors are commonly used to promote bone regeneration; however, the clinical impact is limited because the factors do not last long at a given site.
Ito, Yoshihiro, Kitajima, Takashi, Matsukawa, Akihiro, Mazaki, Tetsuro, Nakamura, Mariko, Ozaki, Toshifumi, Shiozaki, Yasuyuki, Tanaka, Masato, Umezawa, Akihiro, Yoshida, Aki, Yoshida, Yasuhiro   +10 more
core   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

Expand+Functional selection and systematic analysis of intronic splicing elements identify active sequence motifs and associated splicing factors [PDF]

, 2010
Despite the critical role of pre-mRNA splicing in generating proteomic diversity and regulating gene expression, the sequence composition and function of intronic splicing regulatory elements (ISREs) have not been well elucidated.
Berglund, J. Andrew, Culler, Stephanie J., Hoff, Kevin G., Smolke, Christina D., Voelker, Rodger B.   +4 more
core   +4 more sources

Exploring Desmin as a Potential Modifier in Duchenne Muscular Dystrophy–Associated Cardiomyopathy

Acta Physiologica, Volume 241, Issue 12, December 2025.
ABSTRACT Aim Duchenne muscular dystrophy (DMD), a rare X‐linked genetic disorder, is affecting skeletal and cardiac muscles due to the loss of the dystrophin protein. Modifier proteins, whose expression is altered in DMD patients, may influence disease progression.
Brice‐Emmanuel Guennec, Yeranuhi Hovhannisyan, Gaëlle Revet, Sila Polat, Medhi Hassani, Nathalie Mougenot, Inès Barthelemy, Stephane Blot, Caroline Cieniewski‐Bernard, Arnaud Ferry, Ekaterini Kordeli, Zhenlin Li, Onnik Agbulut   +12 more
wiley   +1 more source

Molecular characterization of a carbon dioxide-dependent Escherichia coli small-colony variant isolated from blood cultures

International Journal of Medical Microbiology, 2020
A carbon dioxide-dependent small-colony variant of Escherichia coli SH4888 was isolated from blood cultures of a patient with cholangitis. To date, little is known regarding the molecular mechanisms leading to formation of carbon dioxide-dependent ...
Takehisa Matsumoto, Masayuki Hashimoto, Ching-Hao Teng, Po-Chuen Hsu, Yusuke Ota, Masaru Takamizawa, Ryosuke Kato, Tatsuya Negishi   +7 more
doaj   +1 more source

Hypoxanthine guanine phosphoribosyltransferase 1, a target of miR-125b-5p, promotes cell proliferation and invasion in head and neck squamous cell carcinoma

Heliyon, 2023
The mechanism of hypoxanthine-guanine phosphoribosyltransferase 1 (HPRT1) upregulation and its function in head and neck squamous cell carcinoma (HNSCC) remains obscure.
Li Yuan, Zhiqiang Xiao, Ruohuang Lu
doaj   +1 more source

Inter‐Caste Comparison Reveals a Unique Bioenergetic Signature in Long‐Lived Ant Queens

Molecular Ecology, Volume 34, Issue 21, November 2025.
ABSTRACT Within the same species of eusocial insects, individuals of different castes typically display widely different life‐history traits: sterile workers live for a few months, while queens can live for decades. Ageing theories emphasise the importance of metabolism and oxidative stress in explaining longevity, with mitochondrial bioenergetics ...
Maïly Kervella, Fabrice Bertile, Alexandra Granger‐Farbos, Benoît Pinson, Claire Villette, Dimitri Heintz, Alain Schmitt, Martin Quque, Frédéric Bouillaud, François Criscuolo   +9 more
wiley   +1 more source

Intrauterine Undernourishment Alters TH1/TH2 Cytokine Balance and Attenuates Lung Allergic Inflammation in Wistar Rats [PDF]

, 2012
IL-4 produced by Th2 cells can block cytokine production by Th1 cells, and Th1 IFN-gamma is known to counterregulate Th2 immune response, inhibiting allergic eosinophilia.
Camara, Niels Olsen Saraiva, Fortes, Zuleica B., Landgraf, Maristella de Almeida, Landgraf, Richardt Gama, Semedo, Patricia, Silva, Reinaldo Correia   +5 more
core   +1 more source