Disruption of the Serotonergic System after Neonatal Hypoxia-Ischemia in a Rodent Model [PDF]
Neurology Research International, 2012 Identifying which specific neuronal phenotypes are vulnerable to neonatal hypoxia-ischemia, where in the brain they are damaged, and the mechanisms that produce neuronal losses are critical to determine the anatomical substrates responsible for ...
Kathryn M. Buller +2 more
doaj +2 more sources
A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]
, 2001 Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Darren Caldwell +9 more
core +1 more source
Molecules, 2018 Neonatal hypoxia–ischemia is one of the main causes of mortality and disability of newborns. To study the mechanisms of neonatal brain cell damage, we used a model of neonatal hypoxia–ischemia in seven-day-old rats, by annealing of the common
Denis N. Silachev +8 more
doaj +1 more source
Neurobiology of Disease, 2011 Two-day-old (P2) rat pups were subjected to either a global hypoxia or to electrocoagulation of the right carotid artery followed by 2.5 h hypoxia. Cellular and regional injury in the cerebellum (CB) was studied at 1, 2 and 19 days using immunohistology.
Valerie Biran +7 more
doaj +1 more source
Prednisolone as preservation additive prevents from ischemia reperfusion injury in a rat model of orthotopic lung transplantation [PDF]
, 2013 The lung is, more than other solid organs, susceptible for ischemia reperfusion injury after orthotopic transplantation. Corticosteroids are known to potently suppress pro-inflammatory processes when given in the post-operative setting or during ...
Haitham Mutlak +39 more
core +2 more sources
A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia [PDF]
, 2011 The purine adenosine plays an important role in a number of physiological and pathological processes and is neuroprotective during hypoxia and ischemia.
Mark J. Wall +3 more
core +1 more source
Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]
, 2015 Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Rocha-Ferreira, E +5 more
core +1 more source
Analysis of GWAS-Derived Schizophrenia Genes for Links to Ischemia-Hypoxia Response of the Brain
Frontiers in Psychiatry, 2020 Obstetric complications (OCs) can induce major adverse conditions for early brain development and predispose to mental disorders, including schizophrenia (SCZ).
Rainald Schmidt-Kastner +7 more
doaj +1 more source
Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat [PDF]
, 2012 The main goal of adequate organ preservation is to avoid further cellular metabolism during the phase of ischemia. However, modern preservation solutions do rarely achieve this target.
Paulus, Patrick +26 more
core +2 more sources
The change in the hypoxia resistance at chronic cerebral ischemia
Бюллетень сибирской медицины, 2008 Hypoxia and its related oxidate stress are the direct cause of the neural damage due to chronic cerebral ischemia. Resistance to hypoxia and oxidate stress is the main marker of the human and brain adaptation to chronic ischemia.Hypoxia resistance and ...
Ye. A. Antipenko, A. V. Gustov
doaj +1 more source