Results 41 to 50 of about 432,269 (136)

Overexpression of miR-92a attenuates kidney ischemia–reperfusion injury and improves kidney preservation by inhibiting MEK4/JNK1-related autophagy

Cellular & Molecular Biology Letters, 2023
Background Kidney ischemia–reperfusion injury is inevitable in kidney transplantation, and is essential for primary graft dysfunction and delayed graft function.
Ming Ma, Hui Li, Saifu Yin, Tao Lin, Turun Song   +4 more
doaj   +1 more source

Maternal hypoxia increases hippocampal cell susceptibility to ischemia after middle cerebral artery occlusion in rat offspring [PDF]

, 2017
Introduction : Maternal hypoxia induces an adverse uterine environment and may induce long-term effects in offspring. This study investigated whether maternal hypoxia increases hippocampal cell vulnerability and exacerbates neurological impairments in ...
Lingxing Wang, Honghong Huang, Hongchao Cai, Yafang Chen   +3 more
core   +1 more source

The paradox between resistance to hypoxia and liability to hypoxic damage in hyperglycemic peripheral nerves. Evidence for glycolysis involvement [PDF]

, 1993
Isolated ventral and dorsal rat spinal roots incubated in normal (2.5 mM) or high glucose (25 mM) concentrations or in high concentrations of other hexoses were exposed transiently to hypoxia (30 min) in a solution of low buffering power.
Niedermeier, W., Schneider, Uwe, Grafe, Peter   +2 more
core   +1 more source

Xa inhibitor edoxaban ameliorates hepatic ischemia-reperfusion injury via PAR-2-ERK 1/2 pathway.

PLoS ONE
Hepatic ischemia-reperfusion injury causes liver damage during surgery. In hepatic ischemia-reperfusion injury, the blood coagulation cascade is activated, causing microcirculatory incompetence and cellular injury.
Koki Maeda, Naohisa Kuriyama, Daisuke Noguchi, Takahiro Ito, Kazuyuki Gyoten, Aoi Hayasaki, Takehiro Fujii, Yusuke Iizawa, Yasuhiro Murata, Akihiro Tanemura, Masashi Kishiwada, Shugo Mizuno   +11 more
doaj   +1 more source

Vulnerability of the Developing Brain to Hypoxic-Ischemic Damage: Contribution of the Cerebral Vasculature to Injury and Repair?

Frontiers in Physiology, 2012
As clinicians attempt to understand the underlying reasons for the vulnerability of different regions of the developing brain to injury, it is apparent that little is known as to how hypoxia-ischemia may affect the cerebrovasculature in the developing ...
Ana eBaburamani, Ana eBaburamani, C. Joakim eEk, David W. Walker, David W. Walker, Margie eCastillo-Melendez   +5 more
doaj   +1 more source

Photoacoustic oxygenation imaging to identify ischemia/hypoxia injury and necrosis of intestine after acute intussusception: A comparative study with CDFI/CEUS

Photoacoustics
Acute intussusception is a pediatric abdominal emergency that requires immediate diagnosis and treatment. However, accurately identifying bowel necrosis non-invasively remains challenging with conventional sonography.
Hualin Yan, Zehui Gou, Hong Wang, Xiaoxia Zhu, Juxian Liu, Wenwu Ling, Lin Huang, Yan Luo   +7 more
doaj   +1 more source

Acute Hypobaric and Hypoxic Preconditioning Reduces Myocardial Ischemia-Reperfusion Injury in Rats

Cardiology Research and Practice, 2021
Background. Chronic and/or intermittent exposure to hypobaric hypoxia reportedly exerts cardioprotective effects against ischemia-reperfusion injury. However, few studies have focused on the cardioprotective effects of acute and/or short-term hypobaric ...
Hirofumi Terada, Naoyuki Hirata, Yasuaki Sawashita, Sho Ohno, Yusuke Yoshikawa, Michiaki Yamakage   +5 more
doaj   +1 more source

Regulation of hypoxia-inducible factor 1α and induction of vascular endothelial growth factor in a rat neonatal stroke model

Neurobiology of Disease, 2003
Stroke is a devastating condition occurring in at least 1 in 4000 live births in the neonatal period. Since hypoxia-inducible factor (HIF)-1α can modulate ischemic injury via induction of target genes that may protect cells against ischemia, and is ...
Dezhi Mu, Xiangning Jiang, R.Ann Sheldon, Christine K Fox, Shannon E.G Hamrick, Zinaida S Vexler, Donna M Ferriero   +6 more
doaj   +1 more source

The effects of hyperglycaemic hypoxia on rectification in rat dorsal root axons [PDF]

, 1994
1. Electrotonic responses to 150 ms current pulses were recorded from isolated rat dorsal roots incubated for at least 3 h with either normal (5 mM) or high (25 mM) D-glucose solutions, and with either normal (25 mM) or low (5 mM) bicarbonate ...
U Schneider, H Bostock, Schneider, Uwe, Grafe, Peter, Bostock, Hugh, P Grafe   +5 more
core   +2 more sources

The GluN3A Subunit Exerts a Neuroprotective Effect in Brain Ischemia and the Hypoxia Process

ASN Neuro, 2013
NMDARs ( N -methyl-d-aspartate receptors) mediate the predominantly excitatory neurotransmission in the CNS (central nervous system). Excessive release of glutamate and overactivation of NMDARs during brain ischemia and the hypoxia process are causally ...
Hui Wang, Haitao Yan, Shuzhuo Zhang, Xiaoli Wei, Jianquan Zheng, Jin Li   +5 more
doaj   +1 more source