Results 41 to 50 of about 348,583 (245)

Tumor Necrosis Factor-α Contributes to Ischemia- and Reperfusion-Induced Endothelial Activation in Isolated Hearts [PDF]

, 1999
During myocardial reperfusion, polymorphonuclear neutrophil (PMN) adhesion involving the intercellular adhesion molecule-1 (ICAM-1) may lead to aggravation and prolongation of reperfusion injury.
Kelly, Ralph A., Stefan Zahler, Habazettl, Helmut, Goedecke, Axel, Becker, Bernhard F., Dieter A. Wolf, Christian Kupatt, Helmut Habazettl, Boekstegers, Peter, Bernhard F. Becker, Kupatt, Christian, Peter Boekstegers, Zahler, Stefan, Wolf, Dieter A., Ralph A. Kelly, Axel Goedecke   +15 more
core   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Overexpression of miR-92a attenuates kidney ischemia–reperfusion injury and improves kidney preservation by inhibiting MEK4/JNK1-related autophagy

Cellular & Molecular Biology Letters, 2023
Background Kidney ischemia–reperfusion injury is inevitable in kidney transplantation, and is essential for primary graft dysfunction and delayed graft function.
Ming Ma, Hui Li, Saifu Yin, Tao Lin, Turun Song   +4 more
doaj   +1 more source

Involvement of Nitric Oxide in Microcirculatory Reactions after Ischemia-Reperfusion of the Rat Urinary Bladder [PDF]

, 2009
Background: Nitric oxide ( NO) plays a role in inflammation. Our aim was to investigate the role of NO in the microcirculatory changes after ischemia-reperfusion (I/R) of the bladder using intravital videomicroscopy (IVM).
Bajory, Z., Pajor László, Kiraly, I., Szabó Andrea, Messmer Konrad, Király István, Pajor, L., Bajory Zoltán, Messmer, K., Szabo, A.   +9 more
core   +1 more source

Added Prognostic Value of EEG Reactivity in Comatose Patients Following Cardiac Arrest

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the added prognostic value of EEG reactivity for favorable outcome compared with background analysis during and after targeted temperature management (TTM). Methods Prospective observational cohort study of comatose post–cardiac arrest patients admitted to a single academic center between 2017 and 2022, all undergoing ...
Sarah Caroyer, Marie Obrecht, Charlotte de Maeseneire, Charlotte Damien, Chantal Depondt, Lorenzo Ferlini, Estelle Rikir, Filippo Annoni, Fabio Silvio Taccone, Nicolas Mavroudakis, Benjamin Legros, Nicolas Gaspard   +11 more
wiley   +1 more source

Heat shock protein 70 protects PC12 cells against ischemia-hypoxia/reoxygenation by maintaining intracellular Ca2+ homeostasis

Neural Regeneration Research, 2016
Heat shock protein 70 (HSP70) maintains Ca2+ homeostasis in PC12 cells, which may protect against apoptosis; however, the mechanisms of neuroprotection are unclear.
Yuan Liu, Xue-chun Wang, Dan Hu, Shu-ran Huang, Qing-shu Li, Zhi Li, Yan Qu   +6 more
doaj   +1 more source

Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat

, 2012
The main goal of adequate organ preservation is to avoid further cellular metabolism during the phase of ischemia. However, modern preservation solutions do rarely achieve this target.
Paulus, Patrick, Tacke Sabine, Johannes Holfeld, Karnowski Nora, Patrick Paulus, Holfeld, Johannes, Urbschat, Anja, Urbschat Anja, Zacharowski, Kai, Tacke, Sabine, Ockelmann, Pia, Nora Karnowski, Karnowski, Nora, Bertram Scheller, Scheller, Bertram, Pia Ockelmann, Ellinghaus, Peter, Paulus Patrick, Zacharowski Kai, Sabine Tacke, Ellinghaus Peter, Anja Urbschat, Kai Zacharowski, Peter Ellinghaus, Ockelmann Pia, Scheller Bertram, Holfeld Johannes   +26 more
core   +1 more source

Maternal hypoxia increases hippocampal cell susceptibility to ischemia after middle cerebral artery occlusion in rat offspring [PDF]

, 2017
Introduction : Maternal hypoxia induces an adverse uterine environment and may induce long-term effects in offspring. This study investigated whether maternal hypoxia increases hippocampal cell vulnerability and exacerbates neurological impairments in ...
Lingxing Wang, Honghong Huang, Hongchao Cai, Yafang Chen   +3 more
core   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Effect of neonatal asphyxia on the impairment of the auditory pathway by recording auditory brainstem responses in newborn piglets: a new experimentation model to study the perinatal hypoxic-ischemic damage on the auditory system.

PLoS ONE, 2015
IntroductionHypoxia-ischemia (HI) is a major perinatal problem that results in severe damage to the brain impairing the normal development of the auditory system.
Francisco Jose Alvarez, Miren Revuelta, Francisco Santaolalla, Antonia Alvarez, Hector Lafuente, Olatz Arteaga, Daniel Alonso-Alconada, Ana Sanchez-del-Rey, Enrique Hilario, Agustin Martinez-Ibargüen   +9 more
doaj   +1 more source