Results 71 to 80 of about 123,337 (240)
Neurobiology of Disease, 2003 Stroke is a devastating condition occurring in at least 1 in 4000 live births in the neonatal period. Since hypoxia-inducible factor (HIF)-1α can modulate ischemic injury via induction of target genes that may protect cells against ischemia, and is ...
Dezhi Mu +6 more
doaj +1 more source
Journal of Immunology Research, 2023 Macrophages are the major cells of innate immunity with a wide range of biological effects due to their great plasticity and heterogeneity. Macrophages play a key role in neuroregeneration following nervous tissue injury.
Ivan Mikhailovich Rashchupkin +5 more
doaj +1 more source
Apoptosis and inflammation regulation after injury to the developing brain [PDF]
, 2015 The brain shows greater plasticity in early life than in maturity, which paradoxically renders the organ more vulnerable to hypoxia-ischemia (HI)- and cranial irradiation (IR)- induced damage.
Han, Wei
core +1 more source
Advanced Materials Interfaces, EarlyView.Nanozymes (NZs) have emerged as versatile artificial enzymes with tunable catalytic properties driven by atomic coordination, defect engineering, and surface chemistry. This review presents a bio–nano interface framework linking synthesis strategies, structural design, and catalytic behavior within complex biological microenvironments.
Karen Guadalupe Quintero‐Garrido +6 more
wiley +1 more source
The GluN3A Subunit Exerts a Neuroprotective Effect in Brain Ischemia and the Hypoxia Process
ASN Neuro, 2013 NMDARs ( N -methyl-d-aspartate receptors) mediate the predominantly excitatory neurotransmission in the CNS (central nervous system). Excessive release of glutamate and overactivation of NMDARs during brain ischemia and the hypoxia process are causally ...
Hui Wang +5 more
doaj +1 more source
PLoS ONE, 2012 Perinatal hypoxia-ischemia is a major cause of acute mortality in newborns and cognitive and motor impairments in children. Cerebral hypoxia-ischemia leads to excitotoxicity and necrotic and apoptotic cell death, in which mitochondria play a major role ...
Cláudia S F Queiroga +5 more
doaj +1 more source
Advanced Science, EarlyView.A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie +7 more
wiley +1 more source
Hypoxia-Ischemia in the Immature Brain and Mechanisms of Reducing Tissue Damage [PDF]
, 2012 Cerebral hypoxia-ischemia in human infants presents a complex clinical problem in that no standardized treatment currently exists. With an understanding of the cellular and metabolic changes brought about during hypoxia-ischemia in the immature brain ...
Lehr, Faculty Advisor, Edgar +2 more
core +1 more source
Stroke penumbra defined by an MRI-based oxygen challenge technique: 1. validation using [14C]2-deoxyglucose autoradiography [PDF]
, 2011 Accurate identification of ischemic penumbra will improve stroke patient selection for reperfusion therapies and clinical trials. Current magnetic resonance imaging (MRI) techniques have limitations and lack validation.
Barrie Condon +9 more
core +1 more source
A 3D In Vitro Model of the Human Hepatobiliary Junction
Advanced Science, EarlyView.A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield +13 more
wiley +1 more source