Results 71 to 80 of about 432,269 (136)

Postconditioning protects against endothelial ischemia-reperfusion injury in the human forearm [PDF]

, 2006
Background: Hypoxic cell death follows interruption of blood supply to tissues. Although successful restoration of blood flow is mandatory for salvage of ischemic tissues, reperfusion can paradoxically place tissues at risk of further injury.
MacAllister, R.J., Loukogeorgakis, S.P., Panagiotido, A.T., Yellon, D.M., Deanfield, J.E.   +4 more
core  

KR-33028 attenuates ischemia/hypoxia-induced blood-brain barrier hyperpermeability through maintaining tight junction integrity

, 2012
We have previously demonstrated that KR-33028, a novel inhibitor of Na+/H+ exchanger-1(NHE-1), exerts neuroprotective effects during cerebral ischemia.
Park, Sung Lyea, Yoo, Sung Eun, Lee, Sunkyung, Yi, Kyu Yang, Lee, Dong Ha, Jung, Yi-Sook   +5 more
core   +1 more source

Lactate-proton co-transport and its contribution to interstitial acidification during hypoxia in isolated rat spinal roots [PDF]

, 1993
Exposure of nervous tissue to hypoxia results in interstitial acidification. There is evidence for concomitant decrease in extracellular pH to the increase in tissue lactate.
Schneider, Uwe, Poole, RC, Halestrap, Andrew P., Grafe, Peter, Grafe, P, Poole, Robert C., Schneider, U, Halestrap, AP   +7 more
core   +1 more source

Regulation of Cellular Stress Signaling in Bladder Ischemia

Research and Reports in Urology, 2020
Jing-Hua Yang,1 Yedan Li,2 Roya Azad,2 Kazem Azadzoi3 1Department of Surgery, Boston University School of Medicine, Boston, MA, USA; 2Department of Urology, VA Boston Healthcare System, Boston, MA, USA; 3Department of Urology and Department of Pathology,
Yang J, Li Y, Azad R, Azadzoi K
doaj  

Hypoxia-Induced Inos Expression in Microglia Is Regulated by the P13- Kinase/Akt/Mtor Signaling Pathway and Activation of Hypoxia Inducible Factor-1 Alpha

, 2009
Exposure to hypoxia induced microglia activation and animal studies have shown that neuronal cell death is correlated with microglial activation following cerebral ischemia.
盧大宇;湯智昕;符文美, LU, DAH-YUU;TANG, CHIH-HSIN;FU, WEN-MEI   +1 more
core  

Brain metabolomic profiling reveals ischemia-dominant disruption of metabolic pathways and tissue homeostasis in neonatal hypoxic-ischemic brain injury

Scientific Reports
In neonatal hypoxic-ischemic brain injury (HIBI), a common form of perinatal brain damage associated with mortality and neurological disability, the disruption of oxygen and nutrient supply severely impacts brain metabolism.
Nora Wolff, Maria Triantafyllou, Javid Ghaemmaghami, Georgios Sanidas, Chad Everett Byrd, Gabriele Simonti, Susan Aja, Aurelie Roux, Khyzer Aziz, Evan Goldstein, Jiangyang Zhang, Allen Dale Everett, David Graham, Panagiotis Kratimenos, Ioannis Koutroulis, Frances Northington   +15 more
doaj   +1 more source

Modulating mitochondrial metabolism: a neuroprotective mechanism for hypoxic–ischemic preconditioning

Cell Regeneration
Hypoxia–ischemia plays a role in the physiological and pathological processes of various diseases and presents a common challenge for humans under extreme environmental conditions.
Wenxin Li, Guo Shao, Ruifang Qi
doaj   +1 more source

Sickle Mice Are Sensitive to Hypoxia/Ischemia-Induced Stroke but Respond to Tissue-Type Plasminogen Activator Treatment

, 2017
Background and Purpose— The effects of lytic stroke therapy in patients with sickle cell anemia are unknown, although a recent study suggested that coexistent sickle cell anemia does not increase the risk of cerebral hemorrhage ...
Chia-Yi Kuan, Mary B. Wagner, Yu-Yo Sun, Clinton H. Joiner, Henry Huang, David R. Archer, Jolly Lee   +6 more
core   +1 more source

mRNA D(2) dopaminergic receptor expression after hypoxia-ischemia in rat immature brain

, 2001
Previous studies have shown a reduction of dopaminergic D(2) receptors (D(2)R) in the striatum after hypoxia-ischemia in newborn rats. We show here an early and transient reduction of mRNA D(2)R in nonatrophic brains following hypoxia-ischemia.
Laugier, J, Bodard, S, Cantagrel, S, Chalon, S, Suc, A L, Guilloteau, D, Gressens, P   +6 more
core   +1 more source

Hypoxia-Ischemia in the Immature Brain and Mechanisms of Reducing Tissue Damage [PDF]

, 2012
Cerebral hypoxia-ischemia in human infants presents a complex clinical problem in that no standardized treatment currently exists. With an understanding of the cellular and metabolic changes brought about during hypoxia-ischemia in the immature brain ...
Lehr, Faculty Advisor, Edgar, Simmons, Victoria, Vannucci, Faculty Advisor, Susan   +2 more
core