Results 1 to 10 of about 65,592 (181)

Long non-coding RNA COL4A2-AS1 facilitates cell proliferation and glycolysis of colorectal cancer cells via miR-20b-5p/hypoxia inducible factor 1 alpha subunit axis. [PDF]

Bioengineered, 2021
Long non-coding RNAs (lncRNAs) have critical functions in tumorigenesis and progression of colorectal cancer (CRC). The role of lncRNA COL4A2-AS1 (COL4A2-AS1) lacks system investigation. The current study comprehensively analyzed the expression, biological functions, and mechanism of COL4A2-AS1 in CRC through performing real-time quantitative PCR (RT ...
Yu Z, Wang Y, Deng J, Liu D, Zhang L, Shao H, Wang Z, Zhu W, Zhao C, Ke Q.   +9 more
europepmc   +5 more sources

Suppression of collagen IV alpha‐2 subunit by prolyl hydroxylase domain inhibition via hypoxia‐inducible factor‐1 in chronic kidney disease [PDF]

Pharmacology Research & Perspectives, 2021
Elevation of hypoxia‐inducible factor 1 protein has been shown to be protective in acute kidney injury and HIF1α enhancing drug therapies are currently in clinical trials for the treatment of anemia of chronic kidney disease.
Mohammad Sanaei‐Ardekani, Shyreen Kamal, Whitney Handy, Sidrah Alam, Aya Salaheldin, Anderson Moore, Shahrzad Movafagh   +6 more
doaj   +3 more sources

The association between hypoxia inducible factor 1 subunit alpha gene rs2057482 polymorphism and cancer risk: a meta-analysis [PDF]

BMC Cancer, 2019
Background The rs2057482 polymorphism in the hypoxia inducible factor 1 subunit alpha (HIF1A) gene has been reported to be associated with a risk of several types of cancer, but this association has not yet been definitively confirmed.
Li-Fang Wu, Gui-Ping Xu, Qing Zhao, Li-Jing Zhou, Ding Wang, Wei-Xian Chen   +5 more
doaj   +3 more sources

Analysis of Migration and Adaptive Evolution in Tibetan Sheep Populations [PDF]

Animals
The genetic basis for Tibetan sheep adaptation to different high-altitude environments remains unknown. This study conducted whole-genome resequencing on 80 Tibetan sheep individuals from four major distribution areas on the Qinghai–Tibet Plateau.
Wentao Zhang, Chao Yuan, Tingting Guo, Bowen Chen, Fan Wang, Jianbin Liu, Zengkui Lu   +6 more
doaj   +2 more sources

Effect of melatonin on steroidogenesis-related enzymes expression and testosterone synthesis following CoCl2-induced hypoxia in TM3 Leydig cells [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): This study examined the effects of melatonin treatment on steroidogenesis dysfunction and testosterone impairment, following CoCl2-induced hypoxia in TM3 Leydig cells. Materials and Methods: The TM3 cells were divided into four groups.
shokooh karimi, Cyrus Jalili, Kamran Mansouri, Fariborz Bahremand, Mohammadreza Gholami   +4 more
doaj   +1 more source

Transformer 2 alpha homolog is a downstream gene of hypoxia-inducible factor 1 subunit alpha and is involved in the progression of pancreatic cancer

Bioengineered, 2022
Intratumoral hypoxia is a common feature of pancreatic cancer (PC) and also plays a role in its progression. However, hypoxia-regulated signatures in PC are still not completely understood. This study aimed to identify core hypoxia-associated genes and determine their underlying molecular mechanisms in PC cells.
Wenpeng Cao, Shan Lei, Zhirui Zeng, Chaolun Xiao, Baofei Sun, Peng Xie, Yumei Li, Daopeng Luo, Wenfeng Yu   +8 more
openaire   +2 more sources

Hypoxia and the hypoxia inducible factor 1α activate protein kinase A by repressing RII beta subunit transcription [PDF]

Oncogene, 2020
AbstractOveractivation of the cAMP signal transduction pathway plays a central role in the pathogenesis of endocrine tumors. Genetic aberrations leading to increased intracellular cAMP or directly affecting PKA subunit expression have been identified in inherited and sporadic endocrine tumors, but are rare indicating the presence of nongenomic ...
Lucia, Kristin, Wu, Yonghe, Monteserin Garcia, Jose, Barlier, Anne, Buchfelder, Michael, Saeger, Wolfgang, Renner, Ulrich, Stalla, Guenter K., Theodoropoulou, Marily   +8 more
openaire   +6 more sources

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit [PDF]

Journal of Biological Chemistry, 1997
Hypoxia-inducible factor-1 (HIF-1), a heterodimeric DNA binding complex composed of two basic-helix-loop-helix Per-AHR-ARNT-Sim proteins (HIF-1alpha and -1beta), is a key component of a widely operative transcriptional response activated by hypoxia, cobaltous ions, and iron chelation.
Pugh, C, O'Rourke, J, Nagao, M, Gleadle, J, Ratcliffe, P   +4 more
openaire   +3 more sources

The possible role of hypoxia in the affected tissue of relapsed clubfoot

Scientific Reports, 2022
Our aim was to study the expression of hypoxia-related proteins as a possible regulatory pathway in the contracted side tissue of relapsed clubfoot. We compared the expression of hypoxia-related proteins in the tissue of the contracted (medial) side of ...
Tomas Novotny, Adam Eckhardt, Martina Doubkova, Jarmila Knitlova, David Vondrasek, Eliska Vanaskova, Martin Ostadal, Jiri Uhlik, Lucie Bacakova, Jana Musilkova   +9 more
doaj   +1 more source

Hypoxia-Mediated Complement 1q Binding Protein Regulates Metastasis and Chemoresistance in Triple-Negative Breast Cancer and Modulates the PKC-NF-κB-VCAM-1 Signaling Pathway

Frontiers in Cell and Developmental Biology, 2021
ObjectivesComplement 1q binding protein (C1QBP/HABP1/p32/gC1qR) has been found to be overexpressed in triple-negative breast cancer (TNBC). However, the underlying mechanisms of high C1QBP expression and its role in TNBC remain largely unclear.
Hao Wu, Hao Wu, Hao Wu, Yijun Chu, Yijun Chu, Yijun Chu, Shanshan Sun, Shanshan Sun, Shanshan Sun, Guozheng Li, Guozheng Li, Guozheng Li, Shouping Xu, Shouping Xu, Shouping Xu, Xianyu Zhang, Xianyu Zhang, Xianyu Zhang, Yongdong Jiang, Yongdong Jiang, Yongdong Jiang, Song Gao, Song Gao, Song Gao, Qin Wang, Qin Wang, Qin Wang, Jian Zhang, Da Pang, Da Pang, Da Pang, Da Pang   +31 more
doaj   +1 more source