Results 1 to 10 of about 56,007 (232)

Long non-coding RNA COL4A2-AS1 facilitates cell proliferation and glycolysis of colorectal cancer cells via miR-20b-5p/hypoxia inducible factor 1 alpha subunit axis. [PDF]

Bioengineered, 2021
Long non-coding RNAs (lncRNAs) have critical functions in tumorigenesis and progression of colorectal cancer (CRC). The role of lncRNA COL4A2-AS1 (COL4A2-AS1) lacks system investigation. The current study comprehensively analyzed the expression, biological functions, and mechanism of COL4A2-AS1 in CRC through performing real-time quantitative PCR (RT ...
Yu Z, Wang Y, Deng J, Liu D, Zhang L, Shao H, Wang Z, Zhu W, Zhao C, Ke Q.   +9 more
europepmc   +4 more sources

Suppression of collagen IV alpha‐2 subunit by prolyl hydroxylase domain inhibition via hypoxia‐inducible factor‐1 in chronic kidney disease [PDF]

Pharmacology Research & Perspectives, 2021
AbstractElevation of hypoxia‐inducible factor 1 protein has been shown to be protective in acute kidney injury and HIF1α enhancing drug therapies are currently in clinical trials for the treatment of anemia of chronic kidney disease. Despite its benefits, long‐term HIF1 elevation seems to be associated with additional effects in the kidneys such as ...
Mohammad Sanaei‐Ardekani, Shyreen Kamal, Whitney Handy, Sidrah Alam, Aya Salaheldin, Anderson Moore, Shahrzad Movafagh   +6 more
openaire   +4 more sources

Transformer 2 alpha homolog is a downstream gene of hypoxia-inducible factor 1 subunit alpha and is involved in the progression of pancreatic cancer

Bioengineered, 2022
Intratumoral hypoxia is a common feature of pancreatic cancer (PC) and also plays a role in its progression. However, hypoxia-regulated signatures in PC are still not completely understood. This study aimed to identify core hypoxia-associated genes and determine their underlying molecular mechanisms in PC cells.
Wenpeng Cao, Shan Lei, Zhirui Zeng, Chaolun Xiao, Baofei Sun, Peng Xie, Yumei Li, Daopeng Luo, Wenfeng Yu   +8 more
openaire   +2 more sources

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit [PDF]

Journal of Biological Chemistry, 1997
Hypoxia-inducible factor-1 (HIF-1), a heterodimeric DNA binding complex composed of two basic-helix-loop-helix Per-AHR-ARNT-Sim proteins (HIF-1alpha and -1beta), is a key component of a widely operative transcriptional response activated by hypoxia, cobaltous ions, and iron chelation.
Pugh, C, O'Rourke, J, Nagao, M, Gleadle, J, Ratcliffe, P   +4 more
openaire   +4 more sources

The association between hypoxia inducible factor 1 subunit alpha gene rs2057482 polymorphism and cancer risk: a meta-analysis [PDF]

BMC Cancer, 2019
Abstract Background The rs2057482 polymorphism in the hypoxia inducible factor 1 subunit alpha (HIF1A) gene has been reported to be associated with a risk of several types of cancer, but this association has not yet been definitively confirmed.
Weixian Chen, Ding Wang, Lijing Zhou, Qing Zhao, Li-Fang Wu, Gui-Ping Xu   +5 more
openaire   +4 more sources

Selection and Analysis of a Mutant Cell Line Defective in the Hypoxia-inducible Factor-1 α-Subunit (HIF-1α) [PDF]

Journal of Biological Chemistry, 1998
Hypoxia-inducible expression has been demonstrated for many groups of mammalian genes, and studies of transcriptional control have revealed the existence of hypoxia-responsive elements (HREs) in the cis-acting sequences of several of these genes. These sequences generally contain one or more binding sites for a heterodimeric DNA binding complex termed ...
Wood, S, Wiesener, MS, Yeates, K, Okada, N, Pugh, C, Maxwell, P, Ratcliffe, P   +6 more
openaire   +4 more sources

Activation of the Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones [PDF]

Gastroenterology, 2017
Hypoxia-inducible factor 1α subunit (HIF1A) is a transcription factor that controls the cellular response to hypoxia and is activated in hepatocytes of patients with nonalcoholic fatty liver disease (NAFLD). NAFLD increases the risk for cholesterol gallstone disease by unclear mechanisms.
Hiroaki Yamaguchi, Junta Imai, Midori Honma, Yasuteru Kondo, Tetsuya Yamada, Yoichiro Asai, Yasuhiro Nakamura, Hideki Katagiri, Hideki Katagiri, Hironobu Sasano, Nariyasu Mano, Shojiro Sawada, Masanori Ikeda, Tooru Shimosegawa, Takashi Sugisawa, Keizo Kaneko, Yumiko Chiba, Keigo Murakami, Yoshiyuki Ueno, Sohei Tsukita, Yuta Shirai, Kenji Uno, Shinjiro Kodama, Masamitsu Maekawa, Yuichiro Munakata, Kei Takahashi, Kozo Tanaka   +26 more
openaire   +3 more sources

Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]

, 2020
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P., Leuvenink, Henri G. D., Nieuwenhuijs-Moeke, Gertrude J., Pischke, Soren E., Ploeg, Rutger J., Pol, Robert A., Sanders, Jan Stephan F., Struys, Michel   +7 more
core   +2 more sources

Semaphorin 3A-hypoxia inducible factor 1 subunit alpha co-overexpression enhances the osteogenic differentiation of induced pluripotent stem cells-derived mesenchymal stem cells in vitro

Chinese Medical Journal, 2020
Abstract Background: Mesenchymal stem or stromal cells (MSCs) derived from the induced pluripotent stem cells (iPSCs) have uniform biological activity, which makes the clinical application of MSCs in bone repair possible.
Jing-Yi Li, Ting-Ting Wang, Chong Li, Zhi-Fang Wang, Shan Li, Li Ma, Li-Li Zheng, Li-Shao Guo   +7 more
openaire   +3 more sources

AMP-Activated Protein Kinase alpha 2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1 alpha and a Network of Proteins Affecting Metabolism and Apoptosis [PDF]

, 2017
Rationale: The AMP-activated protein kinase (AMPK) is stimulated by hypoxia, and although the AMPK alpha 1 catalytic subunit has been implicated in angiogenesis, little is known about the role played by the AMPK alpha 2 subunit in vascular repair ...
Ansari, Nariman, Fisslthaler, Beate, Fleming, Ingrid, Frömel, Timo, Heidler, Juliana, Malik, Randa Abdel, Pampaloni, Francesco, Rieger, Michael A., Walzog, Barbara, Wingert, Susanne, Wittig, Ilka, Zippel, Nina, Zukunft, Sven   +12 more
core   +1 more source