Results 11 to 20 of about 56,007 (232)

Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer [PDF]

, 2016
The small GTPase Rab25 has been functionally linked to tumour progression and aggressiveness in ovarian cancer and promotes invasion in three-dimensional environments.
Chalmers, Anthony J., Gomez-Roman, Natividad, McGregor, Fiona, Plumb, Jane   +3 more
core   +1 more source

Musashi mediates translational repression of the Drosophila hypoxia inducible factor. [PDF]

, 2016
Adaptation to hypoxia depends on a conserved α/β heterodimeric transcription factor called Hypoxia Inducible Factor (HIF), whose α-subunit is regulated by oxygen through different concurrent mechanisms.
Acevedo, Julieta María, Bertolin, Agustina Paola, Blanco Obregón, Dalmiro Manuel, Gándara, Lautaro, Kanda, Hiroshi, Katz, Maximiliano Javier, Okano, Hideyuki, Pozzi, María Berta, Sorianello, Eleonora Mariana, Srebrow, Anabella, Wappner, Pablo, Yano, Masato   +11 more
core   +1 more source

Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil [PDF]

, 2018
Purpose of Review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell ...
Aljoufi, Arafat, Broxmeyer, Hal E., Huang, Xinxin, Trinh, Thao   +3 more
core   +1 more source

A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization [PDF]

, 2007
Background Endothelial dysfunction (ED) is functionally characterized by decreased vasorelaxation, increased thrombosis, increased inflammation, and altered angiogenic potential, has been intimately associated with the progression and severity of ...
Ceriello, Antonio, Green, Dixy E., Ihnat, Michael A., Kamat, Chandrashekhar D., Shenoy, Satyendra S, Thorpe, Jessica E, Warnke, Linda A.   +6 more
core   +3 more sources

Gallstones: Bad Company for the Steatotic Liver [PDF]

, 2017
Gallstones are very frequent worldwide with a prevalence ranging from 10% to 15% in Western countries to
Alvaro, Domenico
core   +1 more source

mRNA overexpression of the hypoxia inducible factor 1 alpha subunit gene (HIF1A): An independent predictor of poor overall survival in chronic lymphocytic leukemia

Leukemia Research, 2017
The hypoxia inducible factor 1 (HIF1) is a heterodimeric transcription factor that ultimately regulates cellular responses to changes in oxygen tension. In this study, we examined the potential diagnostic and prognostic potential of the mRNA expression of HIF1 regulatory α-subunit (HIF1A) in chronic lymphocytic leukemia (CLL).
Andreas Scorilas, Vasiliki Pappa, George Dimitriadis, Christos K. Kontos, Georgia Stavroulaki, Konstantinos Gkontopoulos, Efthimia Bazani, Diamantina Vasilatou, Eirini Glezou, Marios A. Diamantopoulos, Sotirios G. Papageorgiou   +10 more
openaire   +5 more sources

EZH2, HIF-1, and their inhibitors: An overview on pediatric cancers [PDF]

, 2018
During the past decades, several discoveries have established the role of epigenetic modifications and cellularmicroenvironment in tumor growth and progression. One of the main representatives concerning epigenetic modification is the polycomb group (PcG)
Antonello Mai, Diana Bellavia, Elisabetta Ferretti, Elisabetta Ferretti, Giuseppe Battaglia, Marco Papale, Marco Tafani   +6 more
core   +2 more sources

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

The Expression Patterns of Hypoxia-Inducing Factor Subunit α-1, Heme Oxygenase, Hypoxia Upregulated Protein 1, and Cardiac Troponin T During Development of the Chicken Heart

Poultry Science, 2007
Oxygen is one of the critical determinants of appropriate embryonic and fetal development, including cardiogenesis. When the demand of tissues for oxygen exceeds oxygen supply, hypoxic conditions develop. In the developing embryo, hypoxia is associated with increased fetal mortality, cerebrovascular anomalies, cardiovascular dysfunction, and altered ...
Avigdor Cahaner, S. Druyan, Christopher M. Ashwell   +2 more
openaire   +2 more sources

Differential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn's disease/infectious colitis and healthy controls [PDF]

, 2013
Background: Inhibition of prolyl hydroxylases (PHDs) leads to the induction of a transcriptional program that, in the gut, promotes intestinal epithelial cell survival.
De Vos, Martine, Ferdinande, Liesbeth, Hindryckx, Pieter, Laukens, Debby, Van Welden, Sophie   +4 more
core   +2 more sources