Results 11 to 20 of about 65,592 (181)

Regulation of the SIAH2-HIF-1 Axis by Protein Kinases and Its Implication in Cancer Therapy

Frontiers in Cell and Developmental Biology, 2021
The cellular response to hypoxia is a key biological process that facilitates adaptation of cells to oxygen deprivation (hypoxia). This process is critical for cancer cells to adapt to the hypoxic tumor microenvironment resulting from rapid tumor growth.
Dazhong Xu, Cen Li
doaj   +1 more source

Inhibiting miR-155 protects against myocardial ischemia/reperfusion injury via targeted regulation of HIF-1α in rats [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): The aim of this study was to identify the role of miR-155 in the myocardial ischemia/reperfusion (I/R) injury through targeting hypoxia-inducible factor 1-alpha (HIF-1α).
Jian-Guo Chen, Xiao-Ming Xu, Hui Ji, Bo Sun   +3 more
doaj   +1 more source

Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship

Molecular Cancer, 2023
Hypoxia develops during the growth of solid tumors and influences tumoral activity in multiple ways. Low oxygen tension is also present in the bone microenvironment where Ewing sarcoma (EwS) – a highly aggressive pediatric cancer – mainly arises. Hypoxia
A. Katharina Ceranski, Martha J. Carreño-Gonzalez, Anna C. Ehlers, Maria Vittoria Colombo, Florencia Cidre-Aranaz, Thomas G. P. Grünewald   +5 more
doaj   +1 more source

Low expression of HIF1AN accompanied by less immune infiltration is associated with poor prognosis in breast cancer

Frontiers in Oncology, 2023
BackgroundHypoxia-inducible factor 1-alpha (HIF-1α) stability and transcriptional action are reduced by the hypoxia-inducible factor 1-alpha subunit suppressor (HIF1AN). Its inappropriate expression is associated with the development of cancer and immune
Shasha Tang, Dongyang Liu, Yuan Fang, Liyun Yong, Yi Zhang, Mengying Guan, Xiaoyan Lin, Hui Wang, Fengfeng Cai   +8 more
doaj   +1 more source

Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]

, 2020
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P., Leuvenink, Henri G. D., Nieuwenhuijs-Moeke, Gertrude J., Pischke, Soren E., Ploeg, Rutger J., Pol, Robert A., Sanders, Jan Stephan F., Struys, Michel   +7 more
core   +2 more sources

Effects of moderate-intensity intermittent hypoxic training on health outcomes of patients recovered from COVID-19: the AEROBICOVID study protocol for a randomized controlled trial

Trials, 2021
Background Recent studies point to a lower number and reduced severity of cases in higher altitude cities with decreased oxygen concentration. Specific literature has shown several benefits of physical training, so, in this sense, physical training with ...
Átila Alexandre Trapé, Marta Camacho-Cardenosa, Alba Camacho-Cardenosa, Eugenio Merellano-Navarro, Jhennyfer Aline Lima Rodrigues, Elisangela Aparecida da Silva Lizzi, Carlos Arterio Sorgi, Marcelo Papoti, Javier Brazo-Sayavera   +8 more
doaj   +1 more source

Claudin-5 Affects Endothelial Autophagy in Response to Early Hypoxia

Frontiers in Physiology, 2021
Hypoxic injury to cerebrovascular endothelial cells (ECs) after stroke leads to blood-brain barrier (BBB) dysfunction, which is commonly associated with disruptions of endothelial tight junctions (TJs) and increased permeability.
Ping Yu, Yanyu Li, Gaoliang Zhong, Wen Li, Bing Chen, Jingjing Zhang   +5 more
doaj   +1 more source

Long Non-Coding RNA MEG8 Suppresses Hypoxia-Induced Excessive Proliferation, Migration and Inflammation of Vascular Smooth Muscle Cells by Regulation of the miR-195-5p/RECK Axis

Frontiers in Molecular Biosciences, 2021
It has been recognized that rebalancing the abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) helps relieve vascular injury.
Dexing Xu, Ruozhu Dai, Hao Chi, Wen Ge, Jingfeng Rong   +4 more
doaj   +1 more source

Activation of the Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones [PDF]

Gastroenterology, 2017
Hypoxia-inducible factor 1α subunit (HIF1A) is a transcription factor that controls the cellular response to hypoxia and is activated in hepatocytes of patients with nonalcoholic fatty liver disease (NAFLD). NAFLD increases the risk for cholesterol gallstone disease by unclear mechanisms.
Asai, Yoichiro, Yamada, Tetsuya, Tsukita, Sohei, Takahashi, Kei, Maekawa, Masamitsu, Honma, Midori, Ikeda, Masanori, Murakami, Keigo, Munakata, Yuichiro, Shirai, Yuta, Kodama, Shinjiro, Sugisawa, Takashi, Chiba, Yumiko, Kondo, Yasuteru, Kaneko, Keizo, Uno, Kenji, Sawada, Shojiro, Imai, Junta, Nakamura, Yasuhiro, Yamaguchi, Hiroaki, Tanaka, Kozo, Sasano, Hironobu, Mano, Nariyasu, Ueno, Yoshiyuki, Shimosegawa, Tooru, Katagiri, Hideki   +25 more
openaire   +2 more sources

Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer [PDF]

, 2016
The small GTPase Rab25 has been functionally linked to tumour progression and aggressiveness in ovarian cancer and promotes invasion in three-dimensional environments.
Chalmers, Anthony J., Gomez-Roman, Natividad, McGregor, Fiona, Plumb, Jane   +3 more
core   +1 more source