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Retraction for Wei et al., Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling. [PDF]

Proc Natl Acad Sci U S A
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Hypoxia-Inducible Factor-1 (HIF-1)

Molecular Pharmacology, 2006
Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional induction of a series of genes that participate in angiogenesis, iron metabolism, glucose metabolism, and cell proliferation/survival. The primary factor mediating this response is the hypoxia-inducible factor-1 (HIF-1), an oxygen-sensitive transcriptional ...
Qingdong Ke, Max Costa
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Hypoxia-Inducible Factor 1 (HIF-1) Pathway

Science's STKE, 2007
Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix-PAS domain transcription factor that is expressed in all metazoan organisms and is composed of HIF-1α and HIF-1β subunits. Under hypoxic conditions, HIF-1 regulates the transcription of hundreds of genes in a cell type–specific manner. The HIF-1α subunit is regulated by O
G. Semenza
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Signal transduction to hypoxia-inducible factor 1

Biochemical Pharmacology, 2002
Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that functions as a master regulator of O2 homeostasis. HIF-1 target genes encode proteins that increase O2 delivery and mediate adaptive responses to O2 deprivation. HIF-1 activity is regulated by the cellular O2 concentration and by the major growth factor-stimulated signal ...
G. Semenza
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Hypoxia-inducible factor-1 (HIF-1)

Critical Care Medicine, 2005
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that acts as a master regulator of gene expression induced by low oxygen conditions (hypoxia) (1).
P. Schumacker
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The role of hypoxia‐inducible factor 1 in tumor immune evasion

Medicinal research reviews (Print), 2020
Hypoxia‐inducible factor 1 (HIF‐1) plays an indispensable role in the hypoxic tumor microenvironment. Hypoxia and HIF‐1 are involved in multiple aspects of tumor progression, such as metastasis, angiogenesis, and immune evasion.
L. You, Wenda Wu, Xu Wang, L. Fang, V. Adam, E. Nepovimova, Qinghua Wu, K. Kuča   +7 more
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Hypoxia Induces Transcription Factor ETS-1 via the Activity of Hypoxia-Inducible Factor-1

Biochemical and Biophysical Research Communications, 2001
ETS-1 plays an important role in angiogenesis and cancer invasion, and hypoxia is a common feature in these phenomena. We examined whether hypoxia influenced ETS-1 expression. Hypoxia induced ETS-1 in a human bladder cancer cell line, T24, and promoter analysis revealed that the deletion of -424 to -279 bp from the human ETS-1 promoter decreased the ...
Yasufumi Sato, Mayumi Abe, Hajime Kurosawa, Kunio Shirato, Manami Oikawa, Wataru Hida   +5 more
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Hypoxia‐inducible factor‐1 and oncogenic signalling

BioEssays, 2004
AbstractAn understanding of underlying mechanisms involved in the activation of HIF‐1 in response to both hypoxic stress and oncogenic signals has important implications for how these processes may become deregulated in human cancer. Changes in microenvironmental stimuli such as hypoxia and growth factors in combination with genetic lesions, such as ...
Bardos, JI, Athcroft, M
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Hypoxia-inducible factor 1 in autoimmune diseases

Cellular Immunology, 2016
Autoimmune disorders are a complicated and varied group of diseases arising from inappropriate immune responses. Recent studies have demonstrated that ongoing inflammatory and immune responses are associated with increased oxygen consumption, a process resulting in localized tissue hypoxia within inflammatory lesions ("inflammatory hypoxia"), in which ...
Wei Deng, Dandan Wang, Lingyun Sun, Xia Li, Xuebing Feng   +4 more
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Tumor Oxygenation and Hypoxia Inducible Factor-1 Functional Inhibition via a Reactive Oxygen Species Responsive Nanoplatform for Enhancing Radiation Therapy and Abscopal Effects.

ACS Nano, 2018
Hypoxia, and hypoxia inducible factor-1 (HIF-1), can induce tumor resistance to radiation therapy. To overcome hypoxia-induced radiation resistance, recent studies have described nanosystems to improve tumor oxygenation for immobilizing DNA damage and ...
Lingtong Meng, Yali Cheng, Xiaoning Tong, Shaoju Gan, Yawen Ding, Yu Zhang, Chao Wang, Lei Xu, Yishen Zhu, Jinhui Wu, Yiqiao Hu, A. Yuan   +11 more
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