Results 331 to 340 of about 678,452 (368)

Hypoxia-inducible factor-1 (HIF-1)

Critical Care Medicine, 2005
P. Schumacker
openaire   +3 more sources

The role of hypoxia‐inducible factor 1 in tumor immune evasion

Medicinal research reviews (Print), 2020
Hypoxia‐inducible factor 1 (HIF‐1) plays an indispensable role in the hypoxic tumor microenvironment. Hypoxia and HIF‐1 are involved in multiple aspects of tumor progression, such as metastasis, angiogenesis, and immune evasion.
L. You, Wenda Wu, Xu Wang, L. Fang, V. Adam, E. Nepovimova, Qinghua Wu, K. Kuča   +7 more
semanticscholar   +1 more source

Hypoxia Induces Transcription Factor ETS-1 via the Activity of Hypoxia-Inducible Factor-1

Biochemical and Biophysical Research Communications, 2001
ETS-1 plays an important role in angiogenesis and cancer invasion, and hypoxia is a common feature in these phenomena. We examined whether hypoxia influenced ETS-1 expression. Hypoxia induced ETS-1 in a human bladder cancer cell line, T24, and promoter analysis revealed that the deletion of -424 to -279 bp from the human ETS-1 promoter decreased the ...
M, Oikawa, M, Abe, H, Kurosawa, W, Hida, K, Shirato, Y, Sato   +5 more
openaire   +2 more sources

Targeting Hypoxia-Inducible Factor-1-Mediated Metastasis for Cancer Therapy

Antioxidants and Redox Signaling, 2020
Significance: Hypoxia is emerging as a crucial regulator of the tumor microenvironment; it governs the metastatic potential of multiple primary cancers.
Zhaowu Ma, Louis Zizhao Wang, Jun-Ting Cheng, W. S. Lam, Xiang Ma, X. Xiang, A. Wong, B. Goh, Q. Gong, G. Sethi, Lingzhi Wang   +10 more
semanticscholar   +1 more source

Tumor Oxygenation and Hypoxia Inducible Factor-1 Functional Inhibition via a Reactive Oxygen Species Responsive Nanoplatform for Enhancing Radiation Therapy and Abscopal Effects.

ACS Nano, 2018
Hypoxia, and hypoxia inducible factor-1 (HIF-1), can induce tumor resistance to radiation therapy. To overcome hypoxia-induced radiation resistance, recent studies have described nanosystems to improve tumor oxygenation for immobilizing DNA damage and ...
Lingtong Meng, Yali Cheng, Xiaoning Tong, Shaoju Gan, Yawen Ding, Yu Zhang, Chao Wang, Lei Xu, Yishen Zhu, Jinhui Wu, Yiqiao Hu, A. Yuan   +11 more
semanticscholar   +1 more source

Hypoxia-inducible factor 1 (HIF-1) in cancer

European Journal of Surgical Oncology (EJSO), 2004
Hypoxia is a common feature of many cancers. It contributes to local and systemic tumour progression as well as potentially compromising radiotherapy and chemotherapy. Hypoxia-inducible factor 1 (HIF-1) is an essential component in changing the transcriptional response of tumours under hypoxia.
M, Quintero, N, Mackenzie, P A, Brennan
openaire   +2 more sources

Hypoxia‐inducible factor‐1 and oncogenic signalling

BioEssays, 2004
AbstractAn understanding of underlying mechanisms involved in the activation of HIF‐1 in response to both hypoxic stress and oncogenic signals has important implications for how these processes may become deregulated in human cancer. Changes in microenvironmental stimuli such as hypoxia and growth factors in combination with genetic lesions, such as ...
Bardos, JI, Athcroft, M
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Dexamethasone impairs hypoxia-inducible factor-1 function

Biochemical and Biophysical Research Communications, 2008
Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription-factor composed of alpha- and beta-subunits. HIF-1 is not only necessary for the cellular adaptation to hypoxia, but it is also involved in inflammatory processes and wound healing. Glucocorticoids (GC) are therapeutically used to suppress inflammatory responses.
A E, Wagner, G, Huck, D P, Stiehl, W, Jelkmann, T, Hellwig-Bürgel   +4 more
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Hypoxia-inducible factor 1 in autoimmune diseases

Cellular Immunology, 2016
Autoimmune disorders are a complicated and varied group of diseases arising from inappropriate immune responses. Recent studies have demonstrated that ongoing inflammatory and immune responses are associated with increased oxygen consumption, a process resulting in localized tissue hypoxia within inflammatory lesions ("inflammatory hypoxia"), in which ...
Wei, Deng, Xuebing, Feng, Xia, Li, Dandan, Wang, Lingyun, Sun   +4 more
openaire   +2 more sources

Hypoxia‐Inducible Factor 1 Inhibitors

2007
The tremendous progress in our understanding of the molecular mechanisms underlying the presence and consequences of hypoxia in human cancers has been accompanied by renewed enthusiasm for the development of therapeutic strategies targeting hypoxic cells signaling pathways.
openaire   +2 more sources