Results 51 to 60 of about 649,237 (386)

Activation of Hypoxia-Inducible Factor-1 in Bacillary Angiomatosis [PDF]

Circulation, 2005
Background— Bartonella species are the only known bacterial pathogens causing vasculoproliferative disorders in humans (bacillary angiomatosis [BA]). Cellular and bacterial pathogenetic mechanisms underlying the induction of BA are largely unknown.
Jeannette Fiebig, Maria Lebiedziejewski, Stephan Huber, Christian Sander, Ingo B. Autenrieth, Urs Ehehalt, Amir S. Yazdi, Volkhard A. J. Kempf, Kari Alitalo, Bernhard R. Brehm, Steffen Müller, Joo-Hee Wälzlein, Burkhardt Schütt, Guntram A. Grassl   +13 more
openaire   +3 more sources

Contribution of hypoxia inducible factor-1 during viral infections

Virulence, 2020
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays critical roles during the cellular response to hypoxia. Under normoxic conditions, its function is tightly regulated by the degradation of its alpha subunit (HIF-1α), which impairs ...
Antonia Reyes, Nicolás Corrales, Nicolás M. S. Gálvez, Susan M. Bueno, Alexis M. Kalergis, Pablo A. González   +5 more
doaj   +1 more source

Regulatory mechanisms of hypoxia‐inducible factor 1 activity: Two decades of knowledge

Cancer Science, 2018
Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator of various genes related to cellular adaptive responses to hypoxia. Dysfunctions in the regulatory systems of HIF‐1 activity have been implicated in the pathogenesis of various diseases ...
S. Koyasu, Minoru Kobayashi, Y. Goto, M. Hiraoka, H. Harada   +4 more
semanticscholar   +1 more source

Furan- and Thiophene-2-Carbonyl Amino Acid Derivatives Activate Hypoxia-Inducible Factor via Inhibition of Factor Inhibiting Hypoxia-Inducible Factor-1

Molecules, 2018
Induction of a series of anti-hypoxic proteins protects cells during exposure to hypoxic conditions. Hypoxia-inducible factor-α (HIF-α) is a major transcription factor that orchestrates this protective effect.
Shin-ichi Kawaguchi, Yuhei Gonda, Takuya Yamamoto, Yuki Sato, Hiroyuki Shinohara, Yohsuke Kobiki, Atsuhiko Ichimura, Takashi Dan, Motohiro Sonoda, Toshio Miyata, Akiya Ogawa, Tadayuki Tsujita   +11 more
doaj   +1 more source

Hypoxia-inducible factor 1a (HIF 1a) and monocarboxylate transporter 1 (MCT 1) in papillary thyroid carcinoma; A study in Sulaimani City/Iraq

Advanced Medical Journal, 2023
Background and objectives: Papillary thyroid carcinoma is one of the most common cancers of human, monocarbox- ylate transporter 1 and hypoxia inducible factor 1 alpha expressions in many tumors have recently being targets for treatment, HIF-1a has been
Hadeel Adnan Yasseen, Ari Mohammed Abdullah   +1 more
doaj   +1 more source

Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1*

Journal of Biological Chemistry, 1996
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix transcription factor that regulates hypoxia-inducible genes including the human erythropoietin (EPO) gene.
B. Jiang, E. Rue, Guang-lan Wang, Rick Roe, G. Semenza   +4 more
semanticscholar   +1 more source

Expression of hypoxia inducible factor 1 alpha and its clinical significance in esophageal carcinoma: A meta-analysis

Tumor Biology, 2017
Many studies have analyzed the relationship between hypoxia inducible factor 1 alpha expression and its relation to differentiation, lymph node metastasis, and other clinicopathological variables of esophageal carcinoma, but the results are still ...
Shao Wu Jing, Jun Wang, Qing Xu
doaj   +1 more source

Hypoxia-Inducible Factor-1 in Physiological and Pathophysiological Angiogenesis: Applications and Therapies

BioMed Research International, 2015
The cardiovascular system ensures the delivery of oxygen and nutrients to all cells, tissues, and organs. Under extended exposure to reduced oxygen levels, cells are able to survive through the transcriptional activation of a series of genes that ...
A. Zimna, M. Kurpisz
semanticscholar   +1 more source

Regulation of a rat VL30 element in human breast cancer cells in hypoxia and anoxia: role of HIF-1 [PDF]

, 2002
Novel approaches to cancer gene therapy currently exploit tumour hypoxia to achieve transcriptional targeting using oxygen-regulated enhancer elements called hypoxia response elements.
A Ido, A L Harris, B Burke, BL Ebert, C E Lewis, E Schreiber, G Meroni, GL Semenza, GL Wang, GR Anderson, GR Anderson, GU Dachs, GU Dachs, H Kimura, H Tian, HI Swanson, I Kvietikova, JD Firth, K Ameri, K Ameri, K Boast, MS Wiesener, P Vaupel, R Kircheis, S Salceda, S Tinton, SD Estes, SM Wood   +27 more
core   +2 more sources

Hypoxia enhances human B19 erythrovirus gene expression in primary erythroid cells [PDF]

, 2004
Human B19 erythrovirus replicates in erythroid progenitors present in bone marrow and fetal tissues where partial oxygen tension is low. Here we show that infected human primary erythroid progenitor cells exposed to hypoxia (1% O2) in vitro increase ...
Aubin, Jean-Thierry, Fichelson, Serge, Gassmann, Max, Hofer, Thomas, Koken, Marcel, Le Guyader, Nathalie, Morinet, Frédéric, NguyenKhac, Florence, Pillet, Sylvie   +8 more
core   +1 more source