Results 61 to 70 of about 678,452 (368)
Tumor Biology, 2017 Pancreatic ductal adenocarcinoma is one of the most lethal cancers. The Hippo pathway is involved in tumorigenesis and remodeling of tumor microenvironments.
Honglong Wei +6 more
doaj +1 more source
Pola MRNA Hypoxia Inducible Factor-1? (HIF-1?) Dan Exkspresi Protein HIF-1? Ginjal Tikus Pada Hipoksia Sistemik Kronik [PDF]
, 2012 Kspresiprotein HIF-1? pada organ ginjal dari tikus yang mengalamikondisi hipoksia secara sistemik menggunakan Hypoxic Chamber dengankadar O2 8% dan Nitrogen 92% dan kelompok kontrol pada kondisinormoksia. Pola mRNA HIF-1? dilihat berdasarkan hasil RT-PCR
Suciati, Y. (Yulia)
core
A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization [PDF]
, 2007 Background Endothelial dysfunction (ED) is functionally characterized by decreased vasorelaxation, increased thrombosis, increased inflammation, and altered angiogenic potential, has been intimately associated with the progression and severity of ...
Ceriello, Antonio +6 more
core +3 more sources
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Effect of low-frequency low-intensity ultrasound with microbubbles on prostate cancer hypoxia
Tumor Biology, 2017 Angiogenesis plays an important role in tumor growth, invasiveness, and metastasis. It is well established that prostate cancer is exposed to fluctuating oxygen tensions and both acute and chronic hypoxia exist, and these conditions can upregulate ...
Rui Hou +4 more
doaj +1 more source
Current Issues in Molecular Biology, 2023 Specificity protein 1 (SP1), hypoxia-inducible factor 1 (HIF-1), and MYC are important transcription factors (TFs). SP1, a constitutively expressed housekeeping gene, regulates diverse yet distinct biological activities; MYC is a master regulator of all ...
Kotohiko Kimura +2 more
doaj +1 more source
Hypoxia-inducible factor-1 in tumour angiogenesis
World Journal of Gastroenterology, 2004 Hypoxia-inducible factor-1 (HIF-1), composed of HIF-alpha and HIF-beta subunits, is a heterodimeric transcriptional activator. In response to hypoxia, stimulation of growth factors, and activation of oncogenes as well as carcinogens, HIF-1alpha is overexpressed and/or activated and targets those genes which are required for angiogenesis, metabolic ...
Yong-Hong, Shi, Wei-Gang, Fang
openaire +2 more sources
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer
Frontiers in Oncology, 2017 Hypoxia-inducible factor 1 alpha (HIF-1α) orchestrates cellular adaptation to low oxygen and nutrient-deprived environment and drives progression to malignancy in human solid cancers. Its canonical regulation involves prolyl hydroxylases (PHDs), which in
L. Iommarini +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source