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Hypoxia, Hypoxia-Inducible Factors and Liver Fibrosis [PDF]
Cells, 2021 Liver fibrosis is a potentially reversible pathophysiological event, leading to excess deposition of extracellular matrix (ECM) components and taking place as the net result of liver fibrogenesis, a dynamic and highly integrated process occurring during ...
Beatrice Foglia +6 more
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Hypoxia and Hypoxia-Inducible Factors in Lymphedema [PDF]
Frontiers in Pharmacology, 2022 Lymphedema is a chronic inflammatory disorder characterized by edema, fat deposition, and fibrotic tissue remodeling. Despite significant advances in lymphatic biology research, our knowledge of lymphedema pathology is incomplete.
Xinguo Jiang +13 more
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Hypoxia-inducible factors: cancer progression and clinical translation [PDF]
The Journal of Clinical Investigation, 2022 Hypoxia-inducible factors (HIFs) are master regulators of oxygen homeostasis that match O2 supply and demand for each of the 50 trillion cells in the adult human body. Cancer cells co-opt this homeostatic system to drive cancer progression. HIFs activate
Elizabeth E. Wicks, Gregg L. Semenza
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Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape [PDF]
Journal of Hematology & Oncology, 2022 Hypoxia, a common feature of the tumor microenvironment in various types of cancers, weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby reducing tumoral immunogenicity.
Qinghua Wu +6 more
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Hypoxia and hypoxia-inducible factors in leukaemias [PDF]
Frontiers in Oncology, 2016 Despite huge improvements in the treatment of leukaemia, the percentage of patients suffering relapse still remains significant. Relapse most often results from a small number of leukaemic stem cells (LSCs) within the bone marrow, which are able to self ...
Margaux eDeynoux +4 more
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Hypoxic stress and hypoxia-inducible factors in leukemias [PDF]
Frontiers in Oncology, 2022 To cope with hypoxic stress, ancient organisms have developed evolutionally conserved programs centered on hypoxia-inducible transcriptional factors (HIFs).
Daniela Magliulo, Rosa Bernardi
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Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair
Cells, 2019 Acute kidney injury (AKI) is a major kidney disease characterized by an abrupt loss of renal function. Accumulating evidence indicates that incomplete or maladaptive repair after AKI can result in kidney fibrosis and the development and progression of ...
Shaoqun Shu +6 more
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Pulmonary Thrombosis Promotes Tumorigenesis via Myeloid Hypoxia-Inducible Factors [PDF]
Biomolecules, 2022 Cancer patients have a greater risk of thrombosis than individuals without cancer. Conversely, thrombosis is a diagnostic predictor of cancer, but the mechanisms by which thrombosis promotes tumor propagation are incompletely understood.
Xiao Lu +3 more
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Renoprotective Role of Hypoxia-Inducible Factors and the Mechanism [PDF]
Kidney Diseases, 2021 Background: The kidney requires abundant blood supply, and oxygen is transmitted by diffusion through blood vessels. Most physiological metabolism of the kidney depends on oxygen, so it is very sensitive to oxygen. An increasing pool of evidence suggests
Qiu-Yu Li +4 more
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Hypoxia-Inducible Factors and the Regulation of Lipid Metabolism
Cells, 2019 Oxygen deprivation or hypoxia characterizes a number of serious pathological conditions and elicits a number of adaptive changes that are mainly mediated at the transcriptional level by the family of hypoxia-inducible factors (HIFs).
Ilias Mylonis +2 more
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