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Hypoxia-inducible factors: cancer progression and clinical translation [PDF]
The Journal of Clinical Investigation, 2022 Hypoxia-inducible factors (HIFs) are master regulators of oxygen homeostasis that match O2 supply and demand for each of the 50 trillion cells in the adult human body. Cancer cells co-opt this homeostatic system to drive cancer progression. HIFs activate
Elizabeth E. Wicks, Gregg L. Semenza
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Hypoxia-Inducible Factors and Cancer [PDF]
Current Sleep Medicine Reports, 2017 Hypoxia inducible factors (HIFs) mediate the transcription of hundreds of genes that allow cells to adapt to hypoxic environments. In this review, we summarize the current state of knowledge about mechanisms of HIF activation in cancer, as well as downstream cancer-promoting consequences such as altered substrate metabolism, angiogenesis, and cell ...
Jonathan C. Jun +4 more
semanticscholar +5 more sources
Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape [PDF]
Journal of Hematology & Oncology, 2022 Hypoxia, a common feature of the tumor microenvironment in various types of cancers, weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby reducing tumoral immunogenicity.
Qinghua Wu +6 more
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Hypoxia and hypoxia-inducible factors in leukaemias [PDF]
Frontiers in Oncology, 2016 Despite huge improvements in the treatment of leukaemia, the percentage of patients suffering relapse still remains significant. Relapse most often results from a small number of leukaemic stem cells (LSCs) within the bone marrow, which are able to self ...
Margaux eDeynoux +4 more
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Hypoxia, Hypoxia-Inducible Factors and Liver Fibrosis
Cells, 2021 Liver fibrosis is a potentially reversible pathophysiological event, leading to excess deposition of extracellular matrix (ECM) components and taking place as the net result of liver fibrogenesis, a dynamic and highly integrated process occurring during ...
Beatrice Foglia +6 more
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Hypoxia inducible factors and diabetes. [PDF]
Journal of Clinical Investigation, 2020 Hypoxia can be defined as a relative deficiency in the amount of oxygen reaching the tissues. Hypoxia inducible factors (HIFs) are critical regulators of the mammalian response to hypoxia.
J. Gunton
semanticscholar +3 more sources
Hypoxia and Hypoxia-Inducible Factors in Lymphedema [PDF]
Frontiers in Pharmacology, 2022 Lymphedema is a chronic inflammatory disorder characterized by edema, fat deposition, and fibrotic tissue remodeling. Despite significant advances in lymphatic biology research, our knowledge of lymphedema pathology is incomplete.
Xinguo Jiang +13 more
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Hypoxic stress and hypoxia-inducible factors in leukemias [PDF]
Frontiers in Oncology, 2022 To cope with hypoxic stress, ancient organisms have developed evolutionally conserved programs centered on hypoxia-inducible transcriptional factors (HIFs).
Daniela Magliulo, Rosa Bernardi
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Hypoxia-Inducible Factors in Cancer. [PDF]
Cancer Res, 2022 Abstract Low oxygen concentrations (hypoxia) are detrimental to most species on Earth; thus, cells have evolved with adaptations allowing them to withstand transient hypoxia. As with other survival pathways, cancer cells have co-opted these mechanisms to keep up with the metabolic demands of rapid growth and proliferation in harsh tumor ...
Kim LC, Simon MC.
europepmc +3 more sources
Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair
Cells, 2019 Acute kidney injury (AKI) is a major kidney disease characterized by an abrupt loss of renal function. Accumulating evidence indicates that incomplete or maladaptive repair after AKI can result in kidney fibrosis and the development and progression of ...
Shaoqun Shu +6 more
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