Results 31 to 40 of about 1,344,802 (358)

SnapShot: Hypoxia-Inducible Factors

Cell, 2015
Molecular oxygen (O2) is a key substrate for mitochondrial ATP production and numerous intracellular biochemical reactions. The maintenance of O2 homeostasis is therefore essential for the survival of most species. During O2 deprivation, mammalian cells rely on multiple adaptations mediated by the hypoxia-inducible factors (HIFs), mTOR, autophagy, and ...
Lee, Kyoung Eun, Simon, M. Celeste
openaire   +2 more sources

Hypoxia-Inducible Factor in Thyroid Carcinoma [PDF]

Journal of Thyroid Research, 2011
Intratumoural hypoxia (low oxygen tension) is associated with aggressive disease and poor prognosis. Hypoxia-inducible factor-1 is a transcription factor activated by hypoxia that regulates the expression of genes that promote tumour cell survival, progression, metastasis, and resistance to chemo/radiotherapy.
Burrows, Natalie, Babur, Muhammad, Resch, Julia, Williams, Kaye J, Brabant, Georg   +4 more
openaire   +3 more sources

Metabolic Regulation of Hypoxia-Inducible Factors in Hypothalamus

Frontiers in Endocrinology, 2021
The earliest hypoxia-inducible factor (HIF) function was to respond to hypoxia or hypoxic conditions as a transcription factor. Recent studies have expanded our understanding of HIF, and a large amount of evidence indicates that HIF has an essential ...
Dan Du, Yugang Zhang, Canjun Zhu, Hong Chen, Jia Sun   +4 more
doaj   +1 more source

Advances in Hypoxia-Inducible Factor Biology [PDF]

Cell Metabolism, 2018
Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis and metabolic activation. Beyond this, HIF influences many other processes. Hypoxia, in part through HIF-dependent mechanisms, influences epigenetic factors, including DNA methylation ...
Choudhry, H, Harris, A
openaire   +3 more sources

HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.PTK6/Brk is a non-receptor tyrosine kinase overexpressed in cancer.
Blokland, NJG, Broos, AWT, Eccles, SA, Hammond, EM, Harvey, AJ, Pires, IM, Poujade, F-A, Senra, JM, Span, PN   +8 more
core   +3 more sources

Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis

Haematologica, 2012
Background Iron metabolism, regulated by the iron hormone hepcidin, and oxygen homeostasis, dependent on hypoxia-inducible factors, are strongly interconnected.
Maria Mastrogiannaki, Pavle Matak, Jacques R.R. Mathieu, Stéphanie Delga, Patrick Mayeux, Sophie Vaulont, Carole Peyssonnaux   +6 more
doaj   +1 more source

Hypoxia up-regulates SERPINB3 through HIF-2\u3b1 in human liver cancer cells. [PDF]

, 2015
SERPINB3 is a cysteine-proteases inhibitor up-regulated in a significant number of cirrhotic patients carrying hepatocellular carcinoma (HCC) and recently proposed as a prognostic marker for HCC early recurrence.
Autelli, Riccardo, Biasiolo, A, Cambieri, I, Cannito, Stefania, Cillo, U, Cillo, U, Colombatto, Sebastiano, David, E, Fasolato, S, Morello, E, Musso, Tiziana, Novo, Erica, Parola, Maurizio, Paternostro, Claudia, Pontisso, P, Quarta, S, Rovida, E, Smedile, Antonina, Turato, C, Tusa, I, Villano, G   +20 more
core   +3 more sources

Functional Repercussions of Hypoxia-Inducible Factor-2α in Idiopathic Pulmonary Fibrosis

Cells, 2022
Hypoxia and hypoxia-inducible factors (HIFs) are essential in regulating several cellular processes, such as survival, differentiation, and the cell cycle; this adaptation is orchestrated in a complex way.
Ana Karen Torres-Soria, Yair Romero, Yalbi I. Balderas-Martínez, Rafael Velázquez-Cruz, Luz Maria Torres-Espíndola, Angel Camarena, Edgar Flores-Soto, Héctor Solís-Chagoyán, Víctor Ruiz, Ángeles Carlos-Reyes, Citlaltepetl Salinas-Lara, Erika Rubí Luis-García, Jaime Chávez, Manuel Castillejos-López, Arnoldo Aquino-Gálvez   +14 more
doaj   +1 more source

Plasma from Volunteers Breathing Helium Reduces Hypoxia-Induced Cell Damage in Human Endothelial Cells-Mechanisms of Remote Protection Against Hypoxia by Helium. [PDF]

, 2019
PurposeRemote ischemic preconditioning protects peripheral organs against prolonged ischemia/reperfusion injury via circulating protective factors. Preconditioning with helium protected healthy volunteers against postischemic endothelial dysfunction.
Augustijn, Quinten JJ, Hollmann, Markus W, Konkel, Moritz, Oei, Gezina TML, Patel, Hemal H, Preckel, Benedikt, Smit, Kirsten F, Weber, Nina C   +7 more
core   +1 more source

Obstructive sleep apnea aggravates neuroinflammation and pyroptosis in early brain injury following subarachnoid hemorrhage via ASC/HIF-1α pathway

Neural Regeneration Research, 2022
[INLINE:1] Obstructive sleep apnea can worsen the prognosis of subarachnoid hemorrhage. However, the underlying mechanism remains unclear. In this study, we established a mouse model of subarachnoid hemorrhage using the endovascular perforation method ...
Jun Xu, Qian Li, Chen-Yu Xu, Shan Mao, Jia-Jia Jin, Wei Gu, Ying Shi, Chun-Fang Zou, Liang Ye   +8 more
doaj   +1 more source