Results 201 to 210 of about 112,633 (288)

Retinal Hypoxia: Relation to Blood Flow and Oxygen Metabolic Biomarkers. [PDF]

Invest Ophthalmol Vis Sci
Blair NP, Leahy S, Matei N, Shahidi M.
europepmc   +1 more source

Apoptotic mechanisms in the neonatal brain following hypoxia-ischemia

, 2011
Introduction: Neonatal encephalopathy is often perinatally acquired and caused by hypoxia-ischemia (HI). Brain injury develops with a delay, over 12-48 hours, after the insult. Hypothermia, an established neuroprotective treatment, saves 1 infant in 9 from neurological deficits suggesting that there is room for further improvement.
openaire  

Optimizing cerebrovascular endothelial health through shear stress modulation

Experimental Physiology, EarlyView.
Abstract The endothelium plays a pivotal role in regulating cerebrovascular blood flow, and its dysfunction increases the risk of cerebrovascular disease. Endothelial shear stress, a primary mechanical stimulus for endothelial nitric oxide production, is a key modulator of vascular adaptation.
Erika Iwamoto, Rintaro Sakamoto, Darren P. Casey   +2 more
wiley   +1 more source

HIF-1α mediated placental ischemic signaling in the development of early-onset preeclampsia. [PDF]

Redox Biol
You K, Tong Y, Sun T, Wang D, Liu Q, Xu X.   +5 more
europepmc   +1 more source

Methodological comparison of fetal brain 1H‐MRS data analysis techniques and gestational age analysis using LCModel in the fetal sheep brain

Experimental Physiology, EarlyView.
Abstract Proton (1H) magnetic resonance spectroscopy (MRS) is a non‐invasive imaging technique that can be used to assess brain metabolism. Establishing reference levels of fetal brain metabolites in a translatable preclinical model is crucial for identifying subtle deviations from normal cerebral development. Herein, we developed a 1H‐MRS protocol for
Jordan A. Minns, Jack R. T. Darby, Georgia K. Williams, Jesse T. Tu, Ziqi Sun, Jessie Guo, Steven P. Miller, Christopher K. Macgowan, Mike Seed, Jamie Near, Janna L. Morrison   +10 more
wiley   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Dexmedetomidine for prevention of postoperative delirium in elderly patients through hypoxia-inducible factor: A narrative review. [PDF]

Medicine (Baltimore)
Zhang J, Wu M, Li L, Wang Y.
europepmc   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

DL-3-n-Butylphthalide Protects Mitochondria Against Ischemia/Hypoxia Damage via Suppressing GCN5L1-Mediated Drp1 Acetylation in Neurons and Mouse Brains. [PDF]

CNS Neurosci Ther
Zhang H, Zhang N, Yang X, Zhang J, Ge X, Wang L, Wang S, Wen Y.   +7 more
europepmc   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source