Results 231 to 240 of about 1,949,320 (295)

Microglia heterogeneity in vascular dementia pathology. [PDF]

iScience
Tan Z, Xu D, Cao Y, Li W, Ma J, Li H, Wei W.   +6 more
europepmc   +1 more source

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

Mitochondrial dysfunction‑driven ferroptosis in cerebral ischemia‑reperfusion injury: Mechanisms and therapeutic strategies (Review). [PDF]

Mol Med Rep
Li J, Liu A, Gao W, Xing L, Duan P, Li H.   +5 more
europepmc   +1 more source

Effects of tempol on renal medullary tissue hypoxia in an ovine model of Gram‐negative septic acute kidney injury

Experimental Physiology, EarlyView.
Abstract Renal arterial infusion of tempol (RAT) at the onset of Gram‐negative sepsis can prevent sepsis‐induced medullary tissue hypoxia and acute kidney injury (AKI). However, it is not known whether treatment with tempol at a clinically relevant time point of sepsis is similarly effective. Thus, we examined whether tempol can reverse renal medullary
Rachel Peiris, Anton Trask‐Marino, Alemayehu Jufar, Ashenafi H. Betrie, Adam Southon, Sally G. Hood, Rinaldo Bellomo, Abraham H. Hulst, Clive N. May, Connie P. C. Ow, Yugeesh R. Lankadeva   +10 more
wiley   +1 more source

Unwinding the Neurovascular Unit: The Vascular Extracellular Matrix and Mechanochemical Collagen Functionalization in Vascular Dementia. [PDF]

Int J Mol Sci
Ellingson A, Kalyanasundaram A, Orgel JPRO.   +2 more
europepmc   +1 more source

Optimizing cerebrovascular endothelial health through shear stress modulation

Experimental Physiology, EarlyView.
Abstract The endothelium plays a pivotal role in regulating cerebrovascular blood flow, and its dysfunction increases the risk of cerebrovascular disease. Endothelial shear stress, a primary mechanical stimulus for endothelial nitric oxide production, is a key modulator of vascular adaptation.
Erika Iwamoto, Rintaro Sakamoto, Darren P. Casey   +2 more
wiley   +1 more source

Exercise-Induced Myonectin Protects Against Cerebral Ischemia-Reperfusion Injury. [PDF]

CNS Neurosci Ther
Zhang J, Chen S, Liu J, Qi X, Zhang X, Lin P, Huang D, Li J.   +7 more
europepmc   +1 more source

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

Contributions of vascular ageing to late‐onset Alzheimer's disease

Experimental Physiology, EarlyView.
Abstract Late‐onset Alzheimer's disease (LOAD) is an age‐related disease that is strongly associated with vascular risk factors and cerebrovascular impairments. As such, changes in the vasculature with advancing age likely contribute to LOAD, but the mechanisms underlying these contributions remain incompletely understood.
Skylyn J. Ferguson, Young Deanna Choi, Ashley E. Walker   +2 more
wiley   +1 more source

Effect of Caffeine on Cell Death, Oxidative Stress, and Microglial Morphology in a Ferret Organotypic Brain Slice Model of Hypoxia-Ischemia. [PDF]

NeuroSci
Brandon OC, Corry KA, Jin ZR, DiNucci KF, Magoon MJ, Schimek N, Moralejo DH, Juul SE, Boyle PM, Nance EA, Wood TR, Kolnik SE.   +11 more
europepmc   +1 more source