Age-Dependent Microglial Activation in Immature Brains After Hypoxia- Ischemia [PDF]
CNS & Neurological Disorders - Drug Targets, 2013 In the present study, we tested whether the ongoing differentiation of microglia in the immature brain results in more robust microglial activation and pro-inflammatory responses than juvenile brains following hypoxia-ischemia (HI). Under normoxic conditions, microglial activation profiles were assessed in postnatal day 9 and postnatal day 30 mice (P9 ...
Peter, Ferrazzano +7 more
openaire +2 more sources
The change in the hypoxia resistance at chronic cerebral ischemia
Бюллетень сибирской медицины, 2008 Hypoxia and its related oxidate stress are the direct cause of the neural damage due to chronic cerebral ischemia. Resistance to hypoxia and oxidate stress is the main marker of the human and brain adaptation to chronic ischemia.Hypoxia resistance and ...
Ye. A. Antipenko, A. V. Gustov
doaj +1 more source
Maternal pomegranate juice intake and brain structure and function in infants with intrauterine growth restriction: A randomized controlled pilot study. [PDF]
, 2019 Polyphenol-rich pomegranate juice has been shown to have benefit as a neuroprotectant in animal models of neonatal hypoxic-ischemia. No published studies have investigated maternal polyphenol administration as a potential neuroprotectant in at-risk ...
Alexopoulos, Dimitrios +7 more
core +2 more sources
Perinatal Human Hypoxia–Ischemia Vulnerability Correlates with Brain Calcification
Neurobiology of Disease, 2001 Deregulation of intracellular calcium homeostasis is widely considered as one of the underlying pathophysiological mechanisms of hypoxic-ischemic brain injury. Whether this alteration can result in cerebral calcification was investigated in basal ganglia, cerebral cortex, and hippocampus of human premature and term neonates together with glial reaction.
Manuel J. Rodrı́guez +4 more
openaire +3 more sources
Late Measures of Brain Injury After Neonatal Hypoxia–Ischemia in Mice [PDF]
Stroke, 2004 Background and Purpose— This work was undertaken to determine to what degree long-term neurofunctional outcome of neonatal hypoxic–ischemic (HI) brain injury in mice correlates with anatomical extent of cerebral damage assessed by magnetic resonance imaging (MRI) and histopathology.
Wu, EX +8 more
openaire +4 more sources
The GluN3A Subunit Exerts a Neuroprotective Effect in Brain Ischemia and the Hypoxia Process
ASN Neuro, 2013 NMDARs ( N -methyl-d-aspartate receptors) mediate the predominantly excitatory neurotransmission in the CNS (central nervous system). Excessive release of glutamate and overactivation of NMDARs during brain ischemia and the hypoxia process are causally ...
Hui Wang +5 more
doaj +1 more source
The spectrum of Ischemia-induced white matter injury varies with age [PDF]
, 2013 Stroke is a neurological condition that targets the whole range of the human population, from the pre-term infant to the elderly and is a major cause of death worldwide (Ingall 2004).
Muscat, Richard +2 more
core +1 more source
Inflammatory Gene Profiling in the Developing Mouse Brain After Hypoxia-Ischemia [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2004 Brain ischemia triggers an inflammatory reaction that progresses for days to weeks and seems to have a role in secondary progression of injury. Inflammation induces a complex pattern of signaling molecules with partly contradictory actions, and the responses may be different in the immature and adult brain.
Maj, Hedtjärn +2 more
openaire +2 more sources
Rodent Hypoxia Ischemia Models for Cerebral Palsy Research: A Systematic Review
Frontiers in Neurology, 2016 Cerebral Palsy (CP) is a complex multifactorial disorder, affecting approximately 2.5-3 per 1000 live term births, and up to 22 per 1000 prematurely born babies. CP results from injury to the developing brain incurred before, during or after birth.
Prakasham eRumajogee +5 more
doaj +1 more source
Hypoxia-Ischemia in the Immature Brain and Mechanisms of Reducing Tissue Damage [PDF]
, 2012 Cerebral hypoxia-ischemia in human infants presents a complex clinical problem in that no standardized treatment currently exists. With an understanding of the cellular and metabolic changes brought about during hypoxia-ischemia in the immature brain ...
Lehr, Faculty Advisor, Edgar +2 more
core +1 more source