Results 191 to 200 of about 123,355 (307)

Beyond Traditional Screening: The Future of Heart Failure Detection With Biomarkers and AI

iNew Medicine, EarlyView.
Advancing HF Screening: Integrating Technology and Risk Factors Across Eras. This diagram provides a comprehensive review of the historical developments and projected trends of heart failure (HF) screening methodologies, with the prevalent risk factors for HF depicted at the base.
Xiaofeng Fang, Yinbo Xu, Yiting Zhao, Liuyi Li, Zhengyi Cheng, Zhongqi Zhang, Yuhang Luo, Qiaoling Liu, Chen Gong, Shichun Shen   +9 more
wiley   +1 more source

Osteopontin Preconditioning Improves the Regenerative Effects of Mesenchymal Stem Cells In Vitro but Not Their Therapeutic Efficacy Following Hypoxia-Ischemia in Mice. [PDF]

Cells
De Palma ST, van Wijk-Eeftink CN, Baak LM, Nijboer CHA, de Theije CGM.   +4 more
europepmc   +1 more source

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Dimethyl malonate preserves brain and neurobehavioral phenotype following neonatal hypoxia-ischemia by inhibiting FTH1-mediated ferritinophagy. [PDF]

Redox Biol
Jin Y, Wang X, Xu X, Zhou X, Wang Q, Zhang L, Li L, Jin M, Ni H.   +8 more
europepmc   +1 more source

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

What are the implications of sex differences in cell death for treatment after neonatal hypoxia-ischemia, if any? [PDF]

Pediatr Res
McDouall A, Wood TR, Lear BA, Davidson JO, Bennet L, Gunn AJ, Dean JM.   +6 more
europepmc   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Sex dimorphism in brain cell death after hypoxia-ischemia in newborn piglets. [PDF]

Pediatr Res
Alonso-Alconada D, Chillida M, Catalan A, Gressens P, Robertson NJ.   +4 more
europepmc   +1 more source

KNC nanozyme repairs hypoxia ischemia brain damage through ALOX12 mediated lipid peroxidation inhibition. [PDF]

Bioact Mater
Dong X, Jiang D, Chen S, Tan J, Zhao J, Liu X, Lu Z, Yeung KWK, Liao Y, Liu X, Ouyang L.   +10 more
europepmc   +1 more source

Postoperative Weight Gain, Due to Fluid Retention After Ovarian Cancer Surgery—How Much Is too Much?

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Postoperative complications after cytoreductive surgery in ovarian cancer patients are associated with impaired survival. Here, we investigated the association between postoperative weight gain due to fluid retention and the development of complications and anastomotic leakage (AL).
Eva K. Egger, Melisa Delen, Hanno Matthaei, Laura Tascon Padron, Carolin Schröder, Milka Marinova, Dominique Koensgen, Alexander Mustea   +7 more
wiley   +1 more source