Results 201 to 210 of about 123,355 (307)

MiR‐145‐5p Attenuates Doxorubicin‐Induced Heart Injury Through Targeting Cardiomyocyte Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Doxorubicin (DOX), a potent anthracycline chemotherapeutic, exhibits dose‐dependent cardiotoxicity that limits its clinical utility. Although miR‐145‐5p demonstrates cardioprotective properties in cardiovascular diseases, its role in DOX‐induced cardiomyopathy remains undefined.
Xing‐Tao Chen, Yong‐Hong Yu, Yan‐Hua Du, Lin Xu, Xiang‐Ping Meng   +4 more
wiley   +1 more source

Corrigendum to "Dimethyl malonate preserves brain and neurobehavioral phenotype following neonatal hypoxia-ischemia by inhibiting FTH1-mediated ferritinophagy" [Redox Biol. 86 (2025) 103792]. [PDF]

Redox Biol
Jin Y, Wang X, Xu X, Zhou X, Wang Q, Zhang L, Li L, Jin M, Ni H.   +8 more
europepmc   +1 more source

TET3‐Mediated m5C Modification of CCAT2 Accelerates Cardiac Microvascular Endothelial Cell Damage in Acute Coronary Syndrome

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Acute coronary syndrome (ACS) is a clinical syndrome involving myocardial ischemia. This study aimed to elucidate the mechanism of TET3 in ACS‐induced CMEC damage, thereby identifying a new target for ACS treatment. The expression of TET3 in ACS patients and healthy subjects was analyzed.
Jun‐Cheng Liu, Wen‐Juan Wang, Ting‐Ting Zhang, Qi‐Chong Yang, Haliminai Dilimulati, Song‐Tao An   +5 more
wiley   +1 more source

Hypoxia-ischemia and sexual dimorphism: modeling mitochondrial dysfunction using brain organoids. [PDF]

Cell Biosci
Gaston-Breton R, Disdier C, Hagberg H, Mabondzo A.   +3 more
europepmc   +1 more source

PRMT5 Mediates Sepsis‐Associated Lung Injury by Modulating JAK1 Arginine Methylation: A Mechanism Study

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Lung injury is a common complication in critical sepsis. PRMT5 is implicated in endothelial inflammation and lung diseases, but its role in sepsis‐associated lung injury remains unclear. This study collected clinical sepsis samples and detected the mRNA expression of PRMT5.
Bo Wang, Zhen Ge, Fei‐Xiang Chen
wiley   +1 more source

Umbilical Cord Blood Endothelial Progenitor Cells Modulate Neurovascular Unit Damage in a Neonatal Rat Model of Hypoxia Ischemia. [PDF]

Stem Cell Rev Rep
Penny TR, Pham Y, Sutherland AE, Jenkin G, Yawno T, Miller SL, McDonald CA.   +6 more
europepmc   +1 more source

RBMX Transcriptionally Repressed by EZH2‐Associated H3K27me3 Modification Attenuates Pyroptosis in Renal Ischemia/Reperfusion Injury via Regulating SIRT3/NLRP3 Inflammasome Activation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ischemic reperfusion injury (IRI) to kidney is a significant clinical factor in acute kidney injury (AKI). This study aimed to investigate the new role of RNA‐binding motif protein X‐linked (RBMX), a modulator of m6A methylation, in renal IRI and to examine the associated regulatory mechanisms. An in vitro renal IRI model was established using
Yi‐Han Wang, Yan Teng, Fang‐Lan Yao, Shu‐Qi Wei, Yan Li   +4 more
wiley   +1 more source

Association between Cold-Inducible RNA-Binding Motif 3 and Hypothermia Effect in Murine Hypoxia-Ischemia Model Measured by Hyperpolarized ¹³C MRI. [PDF]

Dev Neurosci
Liu X, Jiang X, Capper AM, Stewart N, Byrne W, Ji X, Ellison J, Xu D, Ferriero DM.   +8 more
europepmc   +1 more source

Triglyceride‐Glucose Index‐Based Nomogram for Predicting Short‐Term Mortality in Sepsis Patients

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The triglyceride‐glucose (TyG) index, a marker of insulin resistance, is associated with outcomes in critical illness; however, its predictive role for 28‐day mortality in Asian patients with sepsis has not been established. To address this, the current investigation was designed to evaluate its prognostic significance and to construct a risk ...
Jing Zhang, Yu‐Jing Jiang, Ya‐Ting Lv, Tong‐Qin Li, Li Ma   +4 more
wiley   +1 more source

Pharmacokinetics of 7,8-dihydroxyflavone in neonatal mice with hypoxia-ischemia related brain injury. [PDF]

Front Pharmacol
Lim SY, Scarlett CO, Yapici S, Ferrazzano P, Cengiz P.   +4 more
europepmc   +1 more source