Results 211 to 220 of about 123,355 (307)

Protective Effects of Riociguat Against Contrast‐Induced Nephropathy: An Experimental and Machine Learning‐Based Study in Rats

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Contrast‐induced nephropathy (CIN) is an important cause of acute kidney injury following exposure to iodinated contrast media, and effective preventive strategies remain limited. This study investigated the renoprotective effects of riociguat, a soluble guanylate cyclase stimulator, in an experimental rat model of CIN and explored machine ...
Mustafa Begenc Tascanov, Kenan Toprak, Sibel Turedi, İsmail Koyuncu, Zulkif Tanrıverdi, Necip Fazıl Dedeoglu, Halil Fedai, Asuman Bicer, İbrahim Halil Altıparmak, Recep Demirbag, Gencay Sarıısık   +10 more
wiley   +1 more source

Early Dapagliflozin and Melatonin Treatment Ameliorated LV Fibrosis via Suppressing TGF‐β1/Smads and Activating Nrf2‐ARE Signaling in MI Rodent

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study tested whether combined dapagliflozin (DAPA) and melatonin (Mel) therapy was superior to merely one for ameliorating the left ventricular (LV) fibrosis/remodeling and improving LV ejection fraction (LVEF) in rats after acute myocardial infarction (AMI). In vitro study demonstrated that DAPA treatment significantly suppressed the TGF‐
Jiunn‐Jye Sheu, Jui‐Ning Yeh, Han‐Tan Chai, John Y. Chiang, Chi‐Ruei Huang, Jun Guo, Hon‐Kan Yip   +6 more
wiley   +1 more source

Proteomic analysis identifying proteins relevant for treatment success following experimental neonatal inflammation-sensitized hypoxia-ischemia. [PDF]

Pediatr Res
Burkard H, Osredkar D, Maes E, Bernis ME, Bremer AS, Zweyer M, Dowling P, Ohlendieck K, Thoresen M, Sabir H.   +9 more
europepmc   +1 more source

Modified Sleep Apnea Severity Index and Cardiovascular Risk in CPAP‐Intolerant OSA Patients

The Laryngoscope, EarlyView.
The modified sleep apnea severity index (mSASI) combines patient anatomy, weight, sleep study metrics, and symptoms into a composite OSA index ranging from 1 (least severe) to 3 (most severe). Our study found that mSASI correlated better with baseline cardiovascular risk measured by the 5‐year Framingham Risk Score compared to the AHI.
Praneet C. Kaki, Jennifer A. Goldfarb, Melissa Xu, Daniel J. Campbell, Nicole Molin, Erin Creighton, Thomas M. Kaffenberger, Maurits Boon, Colin Huntley   +8 more
wiley   +1 more source

Neuroinflammation mediates the progression of neonate hypoxia-ischemia brain damage to Alzheimer's disease: a bioinformatics and experimental study. [PDF]

Front Aging Neurosci
Zhang S, Zhang R, Chen Z, Shao Z, Li A, Li F, Huang F.   +6 more
europepmc   +1 more source

Incidental pulmonary arteriovenous malformation

Journal of Hospital Medicine, EarlyView.
Mallory A. Von Lotten, Eric Howell, J. Andrew Watson   +2 more
wiley   +1 more source

Endoscopic Suture Ligation and Sclerotherapy for Pharyngolaryngeal Venous Malformation

The Laryngoscope, EarlyView.
This study evaluated suture ligation combined with sclerotherapy in 53 patients with pharyngolaryngeal venous malformations. A single procedure achieved complete resolution in 79.25% of cases, with no serious complications or need for prophylactic tracheostomy.
Jiajun Tian, Juke Ma, Ahmad A. Hariri, Zhenghua Lv, Peng Cui, Wei Xu   +5 more
wiley   +1 more source

Novel purine derivatives mitigate hypoxia ischemia related brain injury through agrin, zyxin and synaptotagmin proteins. [PDF]

Neurotherapeutics
Mabondzo A, Disdier C, Bouzid A, Larbi KS, Tsintzou A, Maïza A, Kim B, Costa N, Harati R, Nguyen AL, Pruvost A, Galons H, Oumata N, Armengaud J, Knijnenburg M, Verma G, Hagberg H, Gressens P, Chen XF, Hamoudi RA, Stonestreet BS.   +20 more
europepmc   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

The Neuroprotective Effects of Caffeine in a Neonatal Hypoxia-Ischemia Model are Regulated through the AMPK/mTOR Pathway. [PDF]

Int J Biol Sci
Bernis ME, Burkard H, Bremer AS, Grzelak K, Zweyer M, Maes E, Nacarkucuk E, Kaibel H, Hakvoort C, Müller A, Sabir H.   +10 more
europepmc   +1 more source