Results 91 to 100 of about 1,288 (185)

Enhancing Flucytosine Anticandidal Activity Using PEGylated Squalene Nanocarrier

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
Our study focused on improving the effectiveness of the antifungal drug 5‐fluorocytosine (5FC) by loading it in micellar structures formed by PEGylated squalene copolymer. The obtained results for 5FC‐loaded micelles showed in vitro prolonged release under physiological conditions and improved in vitro antifungal activity without cytotoxicity for ...
Bogdan‐Florin Craciun, Irina Rosca, Dragos Peptanariu, Mariana Pinteala   +3 more
wiley   +1 more source

Kangbainian Lotion Ameliorates Vulvovaginal Candidiasis in Mice by Inhibiting the Growth of Fluconazole-Resistant Candida albicans and the Dectin-1 Signaling Pathway Activation

Frontiers in Pharmacology, 2022
Vulvovaginal candidiasis (VVC) is an infectious disease caused by Candida species, which affects millions of women worldwide every year. The resistance to available antifungal drugs for clinical treatment is a growing problem. The treatment of refractory
Zewei Chen, Tengshuo Luo, Fengke Huang, Fuzhen Yang, Wenting Luo, Guanfeng Chen, Mengfei Cao, Fengyun Wang, Jun Zhang   +8 more
doaj   +1 more source

Hybrid Nanoparticles Dual‐Loaded With Curcumin and Benzydamine Hydrochloride for the Treatment of Vulvovaginal Candidiasis: From Development to Biological Application In Vitro and In Vivo

Advanced Therapeutics, Volume 8, Issue 1, January 2025.
This study offers new possibilities for the development of silica‐based hybrid nanoparticles by microfluidics and highlights the potential combination of curcumin and benzydamine hydrochloride for the treatment of vulvovaginal candidiasis. This disease is a public health challenge due to its reports of high incidence, recurrences and resistance to ...
Gabriela C. Carvalho, Maria Nolasco Viseu Domingues, Gabriel Davi Marena, Ermei Mäkilä, Jiachen Li, Gésinda Geertsema‐Doornbusch, Cleverton Roberto de Andrade, Marc C. A. Stuart, Mohammad‐Ali Shahbazi, Ione Corrêa, Brandon W. Peterson, Jarno Salonen, Helena F. Florindo, Taís Maria Bauab, Marlus Chorilli, Hélder A. Santos   +15 more
wiley   +1 more source

Exploring the Depths of Cryptic Aspergillosis: Species Variability, Clinical Spectrum, Diagnostic Quandaries and Therapeutic Options [PDF]

Journal of Clinical and Diagnostic Research
Cryptic aspergillosis, characterised by infections caused by non classical Aspergillus species, presents unique challenges in clinical management due to species variability, diverse clinical manifestations, diagnostic complexities, and limited treatment ...
Almas Fathima Upaisal, Anupma Jyoti Kindo   +1 more
doaj   +1 more source

Antifungal Therapy and Probiotics in Women's Health - A Comprehensive Review [PDF]

Candida-induced infections affect millions of women around the world. Therefore, the purpose of this review is to provide a comprehensive analysis of the role of antifungal therapy and probiotics in managing one such infection, vulvovaginal candidiasis ...
Amangeldi, Alma, Baimakhanova, Baiken, Baimakhanova, Gul, Balgimbayeva, Asya, Berezin, Vladimir, Bogoyavlenskiy, Andrey, Kistaubayeva, Aida, Lakh, Olga, Mamirova, Aigerim, Omirbekova, Anel, Orazymbet, Saltanat, Sadanov, Amankeldi, Shorabaev, Erik, Trenozhnikova, Lyudmila, Turlybaeva, Zere   +14 more
core   +2 more sources

Lactams Exhibit Potent Antifungal Activity Against Monospecies and Multispecies Interkingdom Biofilms on a Novel Hydrogel Skin Model

APMIS, Volume 133, Issue 1, January 2025.
ABSTRACT Infections of intact and damaged skin barriers and keratin are frequently associated with complex biofilm communities containing bacteria and fungi, yet there are limited options for successful management. This study intended to focus on the utility of some novel proprietary lactam molecules, quorum sensing (QS)–derived halogenated furanones ...
Hafsa Abduljalil, Om Alkhir Alshanta, Safa Chougule, Mark Butcher, Bryn Short, William McLean, Neil Parry, Joanne O'Keeffe, Gordon Ramage   +8 more
wiley   +1 more source

Multidrug resistance mechanisms and therapeutic strategies in Candida auris [PDF]

In recent years, Candida auris has emerged as a formidable global health threat due to its multidrug resistance, high transmissibility in healthcare settings, and diagnostic challenges. Unlike most Candida species, C. auris can colonize the skin, persist
Alkaabi, Sara
core   +2 more sources

The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies

Chemical Biology &Drug Design, Volume 105, Issue 1, January 2025.
The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual inhibitors. ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates.
Cengiz Zobi, Oztekin Algul
wiley   +1 more source

Research progress of hydrogels in the prevention of pelvic inflammatory disease

MedComm – Biomaterials and Applications, Volume 3, Issue 4, December 2024.
This image summarizes pathogens and therapeutic interventions for pelvic inflammatory disease. We summarize the intrinsic properties of hydrogels and the application methods used in vagina and urinary tract infections. Abstract Pelvic inflammatory disease (PID) is a critical global health concern with the potential to lead to adverse outcomes ...
Yile Xiao, Teng Ma, Haoming Wu, Qiao Su, Yayu Zhou, Bingnan Zhou, Keyi Yang, Zhengguang Pu, Wanyue Feng, Xin Yong, Huili Zhu, Xulin Hu   +11 more
wiley   +1 more source

In Vitro Activity of Ibrexafungerp, a Novel Glucan Synthase Inhibitor against Candida glabrata Isolates with FKS Mutations [PDF]

Antimicrobial Agents and Chemotherapy, 2019
Ibrexafungerp is a first-in-class glucan synthase inhibitor. In vitro activity was determined for 89 Candida glabrata isolates with molecularly identified FKS1 or FKS2 mutations conferring resistance to the echinocandins.
Natalie S, Nunnally, Kizee A, Etienne, David, Angulo, Shawn R, Lockhart, Elizabeth L, Berkow   +4 more
openaire   +2 more sources