Inherited chromosomally integrated human herpesvirus 6: regional variation in prevalence, association with angina, and identification of ancestral viral lineages in two large UK studies [PDF]
Journal of VirologyTens of millions of people worldwide have inherited chromosomally integrated human herpesvirus 6 (iciHHV-6), yet we know little about the consequences.
Nick Orr, Archie Campbell, Jenna Nichols
exaly +10 more sources
Inherited Chromosomally Integrated Human Herpesvirus 6: Laboratory and Clinical Features [PDF]
Microorganisms, 2023 Inherited chromosomally integrated human herpesvirus 6 (iciHHV-6) is a condition in which the complete HHV-6 genome is integrated into the chromosomes of the host germ cell and is vertically transmitted.
Liliana Gabrielli +10 more
doaj +8 more sources
iciHHV-6 in a Patient With Multisystem Inflammatory Syndrome in Children [PDF]
Pediatrics, 2021 Multisystem inflammatory syndrome in children (MIS-C) is a serious, sometimes life-threatening late complication of coronavirus disease 2019 (COVID-19) with multiorgan involvement and evidence of immune activation. The pathogenesis of MIS-C is not known, nor is the pathogenesis of the severe organ damage that is the hallmark of MIS-C. Human herpesvirus
Michael C Spaeder, Steven L Zeichner
exaly +5 more sources
Investigation of Inherited Chromosomally Integrated Human Herpesvirus-6A+ and -6B+ in a Patient with Ulipristal Acetate-Induced Fulminant Hepatic Failure [PDF]
Viruses, 2021 Inherited chromosomally integrated (ici) human herpes virus 6 (HHV-6) is estimated to occur in 0.6–2.7% of people worldwide. HHV-6 comprises two distinct species: HHV-6A and HHV-6B. Both HHV-6A and HHV-6B integration have been reported. Several drugs are
Laure Izquierdo +6 more
doaj +6 more sources
Endogenous human herpesviruses 6A/B [PDF]
Journal of VirologyHuman herpesviruses 6A and 6B (HHV-6A/B) can integrate into the germline, resulting in inherited viral DNA—now proposed to be called “endogenous HHV-6A/B (eHHV-6A/B).” Present in 0.2–3% of humans, this integrated DNA is passed to offspring and may ...
Louis Flamand +17 more
doaj +5 more sources
Excision of Integrated Human Herpesvirus 6A Genomes Using CRISPR/Cas9 Technology [PDF]
Microbiology Spectrum, 2023 Human herpesviruses 6A and 6B are betaherpesviruses that can integrate their genomes into the telomeres of latently infected cells. Integration can also occur in germ cells, resulting in individuals who harbor the integrated virus in every cell of their ...
Giulia Aimola +2 more
exaly +5 more sources
Unbiased optical mapping of telomere-integrated endogenous human herpesvirus 6 [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Next-generation sequencing technologies allowed sequencing of thousands of genomes. However, there are genomic regions that remain difficult to characterize, including telomeres, centromeres, and other low-complexity regions, as well as transposable ...
Darren J Wight, Giulia Aimola, Amr Aswad
exaly +5 more sources
Fetal cord plasma herpesviruses and preeclampsia: an observational cohort study [PDF]
Scientific ReportsA previous study suggested that fetal inheritance of chromosomally integrated human herpesvirus 6 (ici-HHV6) is associated with the hypertensive pregnancy disorder preeclampsia (PE). We aimed to study this question utilizing cord plasma samples (n = 1276)
Inka Häkkinen +13 more
doaj +5 more sources
Fetal inheritance of chromosomally integrated human herpesvirus 6 predisposes the mother to pre-eclampsia [PDF]
Nature Microbiology, 2020 Pre-eclampsia (typically characterized by new-onset hypertension and proteinuria in the second half of pregnancy) represents a major determinant of the global burden of disease1,2.
Francesca Gaccioli +2 more
exaly +4 more sources
Evolutionary History of Endogenous Human Herpesvirus 6 Reflects Human Migration out of Africa. [PDF]
Mol Biol Evol, 2021 Human herpesvirus 6A and 6B (HHV-6) can integrate into the germline, and as a result, similar to 70 million people harbor the genome of one of these viruses in every cell of their body.
Aswad A +17 more
europepmc +6 more sources