Transmission dynamics of human herpesvirus 6A, 6B and 7 from whole genome sequences of families [PDF]
Virology Journal, 2022 While hundreds of thousands of human whole genome sequences (WGS) have been collected in the effort to better understand genetic determinants of disease, these whole genome sequences have less frequently been used to study another major determinant of ...
Brianna S. Chrisman +5 more
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Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A [PDF]
Frontiers in Microbiology, 2019 Human herpesvirus-6A (HHV-6A) and 6B (HHV-6B) are two closely related betaherpesviruses that are associated with various diseases including seizures and encephalitis.
Anthony J. Saviola +12 more
doaj +3 more sources
The case of inherited chromosomal integrated human herpes virus type 6b in child with recurrent respiratory tract infections [PDF]
Журнал инфектологии, 2020 The five years old boy with recurrent respiratory tract infections was under observation of infectiologist due to high levels of human herpes virus type 6 (HHV-6), found in patient’s blood and saliva during a few years.
M. A. Nikolsky +4 more
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Meningoencephalitis in a background of inherited chromosomic integration of HHV-6 and CMV infection in an immunocompetent adult, which one is the culprit? [PDF]
IDCasesHHV-6 meningoencephalitis has been reported in immunocompromised individuals but is very uncommon in immunocompetent individuals. However, HHV-6 is the second most frequently detected virus in multiplex PCR tests. As HHV-6 DNA integrates in the telomeric
Anne-Laure Lajoye +3 more
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Case Report: Inherited chromosomally integrated HHV-6B in a pediatric medulloblastoma patient with encephalitis [PDF]
Frontiers in ImmunologyBackgroundHuman herpesvirus 6B (HHV-6B) is associated with various central nervous system (CNS) disorders, particularly in immunocompromised patients. We present a rare case of inherited chromosomally integrated HHV-6B (iciHHV-6B), also referred to as ...
Scott Sun +11 more
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Higher-Order Chromatin Structures of Chromosomally Integrated HHV-6A Predict Integration Sites. [PDF]
Front Cell Infect Microbiol, 2021 Human herpesvirus -6A and 6B (HHV-6A/B) can integrate their genomes into the telomeres of human chromosomes. Viral integration can occur in several cell types, including germinal cells, resulting in individuals that harbor the viral genome in every cell ...
Mariani M +10 more
europepmc +3 more sources
Variation in human herpesvirus 6B telomeric integration, excision, and transmission between tissues and individuals. [PDF]
Elife, 2021 Human herpesviruses 6A and 6B (HHV-6A/6B) are ubiquitous pathogens that persist lifelong in latent form and can cause severe conditions upon reactivation.
Wood ML +14 more
europepmc +4 more sources
Comparative genomic, transcriptomic, and proteomic reannotation of human herpesvirus 6
BMC Genomics, 2018 Background Human herpesvirus-6A and -6B (HHV-6) are betaherpesviruses that reach > 90% seroprevalence in the adult population. Unique among human herpesviruses, HHV-6 can integrate into the subtelomeric regions of human chromosomes; when this occurs in ...
Alexander Greninger +2 more
exaly +3 more sources
Latency, Integration, and Reactivation of Human Herpesvirus-6
Viruses, 2017 Human herpesvirus-6A (HHV-6A) and human herpesvirus-6B (HHV-6B) are two closely related viruses that infect T-cells. Both HHV-6A and HHV-6B possess telomere-like repeats at the terminal regions of their genomes that facilitate latency by integration into
Shara N. Pantry, Peter G. Medveczky
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Persistent viremia in an immunocompetent patient with inherited chromosomally integrated HHV-6B. [PDF]
Access Microbiol, 2021 Human herpesvirus-6 (HHV-6), the virus which causes roseola, has traditionally been associated with benign and self-limited childhood illness. However, HHV-6 establishes lifelong latency and can reactivate in immunocompromised adult patients. In about 1%
Obeid M, Gakhal I, McDonald PJ.
europepmc +2 more sources