Results 11 to 20 of about 77,918,908 (98)

The immediate-early protein 1 of human herpesvirus 6B interacts with NBS1 and inhibits ATM signaling [PDF]

EMBO Reports
Viral infection often trigger an ATM serine/threonine kinase (ATM)-dependent DNA damage response in host cells that suppresses viral replication. Viruses evolved different strategies to counteract this antiviral surveillance system.
Vanessa Collin, Élise Biquand, Vincent Tremblay, Élise G Lavoie, Andréanne Blondeau, Annie Gravel, Maxime Galloy, Anahita Lashgari, Julien Dessapt, Jacques Côté, Louis Flamand, Amélie Fradet-Turcotte   +11 more
doaj   +3 more sources

Excision of Integrated Human Herpesvirus 6A Genomes Using CRISPR/Cas9 Technology. [PDF]

Microbiology Spectrum, 2023
Human herpesviruses 6A and 6B are betaherpesviruses that can integrate their genomes into the telomeres of latently infected cells. Integration can also occur in germ cells, resulting in individuals who harbor the integrated virus in every cell of their ...
Louis Flamand, Darren J Wight, Giulia Aimola   +2 more
exaly   +4 more sources

Endogenous human herpesviruses 6A/B [PDF]

Journal of Virology
Human herpesviruses 6A and 6B (HHV-6A/B) can integrate into the germline, resulting in inherited viral DNA—now proposed to be called “endogenous HHV-6A/B (eHHV-6A/B).” Present in 0.2–3% of humans, this integrated DNA is passed to offspring and may ...
Louis Flamand, Jesse Arbuckle, Pascale Bonnafous, Vincent Descamps, Joshua A. Hill, Ruth Jarrett, Keith Jerome, Benedikt B. Kaufer, Rie Koide, Anthony L. Komaroff, Peter Medveczky, Hiroki Miura, Yasuko Mori, Nicholas Parrish, Philip E. Pellett, Michael Wood, Tetsushi Yoshikawa, Danielle M. Zerr   +17 more
doaj   +2 more sources

Comparative genomic, transcriptomic, and proteomic reannotation of human herpesvirus 6

BMC Genomics, 2018
Background Human herpesvirus-6A and -6B (HHV-6) are betaherpesviruses that reach > 90% seroprevalence in the adult population. Unique among human herpesviruses, HHV-6 can integrate into the subtelomeric regions of human chromosomes; when this occurs in ...
Alexander L. Greninger, Giselle M. Knudsen, Pavitra Roychoudhury, Derek J. Hanson, Ruth Hall Sedlak, Hong Xie, Jon Guan, Thuy Nguyen, Vikas Peddu, Michael Boeckh, Meei-Li Huang, Linda Cook, Daniel P. Depledge, Danielle M. Zerr, David M. Koelle, Soren Gantt, Tetsushi Yoshikawa, Mary Caserta, Joshua A. Hill, Keith R. Jerome   +19 more
doaj   +2 more sources

Latency, Integration, and Reactivation of Human Herpesvirus-6

Viruses, 2017
Human herpesvirus-6A (HHV-6A) and human herpesvirus-6B (HHV-6B) are two closely related viruses that infect T-cells. Both HHV-6A and HHV-6B possess telomere-like repeats at the terminal regions of their genomes that facilitate latency by integration into
Shara N. Pantry, Peter G. Medveczky
doaj   +2 more sources

Chromosomal integration of HHV-6A during non-productive viral infection

Scientific Reports, 2017
Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are two different species of betaherpesviruses that integrate into sub-telomeric ends of human chromosomes, for which different prevalence rates of integration have been reported.
Nitish Gulve, Celina Frank, Maximilian Klepsch, Bhupesh K. Prusty   +3 more
doaj   +2 more sources

Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A [PDF]

Frontiers in Microbiology, 2019
Human herpesvirus-6A (HHV-6A) and 6B (HHV-6B) are two closely related betaherpesviruses that are associated with various diseases including seizures and encephalitis.
Anthony J. Saviola, Cosima Zimmermann, Michael P. Mariani, Sylvia A. Signorelli, Diana L. Gerrard, Joseph R. Boyd, Darren J. Wight, Guillaume Morissette, Annie Gravel, Isabelle Dubuc, Louis Flamand, Benedikt B. Kaufer, Seth Frietze   +12 more
doaj   +2 more sources

Actualités sur la forme intégrée du génome du sixième herpesvirus humain au génome humain (iciHHV-6) [PDF]

Medecine/Sciences, 2017
Agnes Gautheret-Dejean
exaly   +3 more sources

Inherited chromosomally integrated human herpesvirus 6: demographics and disease [PDF]

, 2016
Human herpesvirus (HHV) –6A and HHV-6B are unique among herpesviruses in their ability to integrate into the telomeres of human chromosomes and be inherited in a Mendelian fashion. Based on current data, inherited chromosomally integrated HHV-6 (iciHHV-6)
Bell, Adam Joseph
core   +7 more sources

Associations of Inherited Chromosomally-Integrated Human Herpesvirus 6 With Dementia Incidence, Inflammation, and Other Dementia Risk Factors in the UK Biobank. [PDF]

J Med Virol
The infection theory of dementia states that viral infections and chronic inflammation play a role in its pathogenesis. We aimed to test whether testing positive for inherited chromosomally‐integrated human herpesvirus 6 (iciHHV‐6) is associated with an ...
Qiya Z, Mandic M, Waterboer T, Ruijie X, Brenner H, Schöttker B.   +5 more
europepmc   +2 more sources