Results 11 to 20 of about 9,449,320 (101)

The proteomic and metabolomic signature of inherited chromosomally integrated HHV-6 and its role in all-cause dementia and mortality risk: The UK Biobank study. [PDF]

Alzheimers Dement (N Y)
Abstract OBJECTIVE To examine associations of inherited chromosomally integrated human herpesvirus 6 (iciHHV‐6) with incident dementia and mortality, characterize proteomic and metabolomic correlates of carrier status, and evaluate whether these biomarkers relate to dementia and mortality risk.
Beydoun MA, Song M, Yun C, Noren Hooten N, Weiss J, Beydoun HA, Duggan MR, Walker KA, Launer LJ, Evans MK, Zonderman AB.   +10 more
europepmc   +3 more sources

Comparative genomic, transcriptomic, and proteomic reannotation of human herpesvirus 6

BMC Genomics, 2018
Background Human herpesvirus-6A and -6B (HHV-6) are betaherpesviruses that reach > 90% seroprevalence in the adult population. Unique among human herpesviruses, HHV-6 can integrate into the subtelomeric regions of human chromosomes; when this occurs in ...
Alexander L. Greninger, Giselle M. Knudsen, Pavitra Roychoudhury, Derek J. Hanson, Ruth Hall Sedlak, Hong Xie, Jon Guan, Thuy Nguyen, Vikas Peddu, Michael Boeckh, Meei-Li Huang, Linda Cook, Daniel P. Depledge, Danielle M. Zerr, David M. Koelle, Soren Gantt, Tetsushi Yoshikawa, Mary Caserta, Joshua A. Hill, Keith R. Jerome   +19 more
doaj   +2 more sources

Latency, Integration, and Reactivation of Human Herpesvirus-6

Viruses, 2017
Human herpesvirus-6A (HHV-6A) and human herpesvirus-6B (HHV-6B) are two closely related viruses that infect T-cells. Both HHV-6A and HHV-6B possess telomere-like repeats at the terminal regions of their genomes that facilitate latency by integration into
Shara N. Pantry, Peter G. Medveczky
doaj   +2 more sources

Actualités sur la forme intégrée du génome du sixième herpesvirus humain au génome humain (iciHHV-6) [PDF]

Medecine/Sciences, 2017
Agnes Gautheret-Dejean
exaly   +3 more sources

Inherited chromosomally integrated human herpesvirus 6: demographics and disease [PDF]

, 2016
Human herpesvirus (HHV) –6A and HHV-6B are unique among herpesviruses in their ability to integrate into the telomeres of human chromosomes and be inherited in a Mendelian fashion. Based on current data, inherited chromosomally integrated HHV-6 (iciHHV-6)
Bell, Adam Joseph
core   +7 more sources

Herpesvirus genome integration in whole-genome sequences of dementia and control cohorts. [PDF]

Alzheimers Dement
Abstract INTRODUCTION The infectious hypothesis suggests that microbes like herpesviruses may play a role in the pathogenesis of Alzheimer's disease (AD) and other related dementias through methods that may include viral genome integration. The occurrence of herpesvirus genome integration in dementia patients has not been thoroughly characterized ...
Piotrowski SL, Allnutt MA, Johnson K, Tanaka T, Ferrucci L, Morris H, Hardy J, PROSPECT Consortium, Ryten M, United Kingdom Brain Expression Consortium (UKBEC), Logroscino G, Troncoso J, Beach TG, Serrano GE, Cruchaga C, Dickson DW, Ross OA, Chiò A, International LBD Genomics Consortium, International ALS Genomics Consortium, Houlden H, American Genome Center, Dalgard CL, Ding J, Gibbs JR, Traynor BJ, Scholz SW, Jacobson S.   +27 more
europepmc   +2 more sources

Excision of Integrated Human Herpesvirus 6A Genomes Using CRISPR/Cas9 Technology [PDF]

Microbiology Spectrum, 2023
Louis Flamand, Darren Wight, Giulia Aimola   +2 more
exaly   +2 more sources

Chromosome-Specific Human Herpesvirus 6 Integration and Hematologic Malignancies [PDF]

Journal of Virology, 2022
Pavitra Roychoudhury, Alexander Greninger, Joshua Hill   +2 more
exaly   +2 more sources

Associations of Inherited Chromosomally-Integrated Human Herpesvirus 6 With Dementia Incidence, Inflammation, and Other Dementia Risk Factors in the UK Biobank. [PDF]

J Med Virol
The infection theory of dementia states that viral infections and chronic inflammation play a role in its pathogenesis. We aimed to test whether testing positive for inherited chromosomally‐integrated human herpesvirus 6 (iciHHV‐6) is associated with an ...
Qiya Z, Mandic M, Waterboer T, Ruijie X, Brenner H, Schöttker B.   +5 more
europepmc   +2 more sources

Anti-NMDA receptor encephalitis in the setting of inherited chromosomally integrated human herpesvirus 6B (iciHHV-6B): A case report [PDF]

IDCases
Armando Páez
exaly   +2 more sources