Results 11 to 20 of about 208 (88)

Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A [PDF]

Frontiers in Microbiology, 2019
Human herpesvirus-6A (HHV-6A) and 6B (HHV-6B) are two closely related betaherpesviruses that are associated with various diseases including seizures and encephalitis.
Anthony J. Saviola, Cosima Zimmermann, Michael P. Mariani, Sylvia A. Signorelli, Diana L. Gerrard, Joseph R. Boyd, Darren J. Wight, Guillaume Morissette, Annie Gravel, Isabelle Dubuc, Louis Flamand, Benedikt B. Kaufer, Seth Frietze   +12 more
doaj   +3 more sources

The case of inherited chromosomal integrated human herpes virus type 6b in child with recurrent respiratory tract infections [PDF]

Журнал инфектологии, 2020
The five years old boy with recurrent respiratory tract infections was under observation of infectiologist due to high levels of human herpes virus type 6 (HHV-6), found in patient’s blood and saliva during a few years.
M. A. Nikolsky, A. A. Vyazovaya, D. A. Lioznov, O. V. Narvskaya, N. N. Smirnova   +4 more
doaj   +3 more sources

Latency, Integration, and Reactivation of Human Herpesvirus-6

Viruses, 2017
Human herpesvirus-6A (HHV-6A) and human herpesvirus-6B (HHV-6B) are two closely related viruses that infect T-cells. Both HHV-6A and HHV-6B possess telomere-like repeats at the terminal regions of their genomes that facilitate latency by integration into
Shara N. Pantry, Peter G. Medveczky
doaj   +3 more sources

The immediate-early protein 1 of human herpesvirus 6B interacts with NBS1 and inhibits ATM signaling [PDF]

EMBO Reports
Viral infection often trigger an ATM serine/threonine kinase (ATM)-dependent DNA damage response in host cells that suppresses viral replication. Viruses evolved different strategies to counteract this antiviral surveillance system.
Vanessa Collin, Élise Biquand, Vincent Tremblay, Élise G Lavoie, Andréanne Blondeau, Annie Gravel, Maxime Galloy, Anahita Lashgari, Julien Dessapt, Jacques Côté, Louis Flamand, Amélie Fradet-Turcotte   +11 more
doaj   +2 more sources

Chromosomal integration of HHV-6A during non-productive viral infection

Scientific Reports, 2017
Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are two different species of betaherpesviruses that integrate into sub-telomeric ends of human chromosomes, for which different prevalence rates of integration have been reported.
Nitish Gulve, Celina Frank, Maximilian Klepsch, Bhupesh K. Prusty   +3 more
doaj   +2 more sources

The iciHHV-6 Sense: Sensing the Source and Relevance of Human Herpesvirus 6 (HHV-6) DNA in the Transplant Recipient With Inherited Chromosomally Integrated HHV-6 [PDF]

The Journal of Infectious Diseases
Madeleine R Heldman, Alexander L Greninger, Joshua A Hill   +2 more
openaire   +3 more sources

Evolutionary History of Endogenous Human Herpesvirus 6 Reflects Human Migration out of Africa. [PDF]

Mol Biol Evol, 2021
Human herpesvirus 6A and 6B (HHV-6) can integrate into the germline, and as a result, similar to 70 million people harbor the genome of one of these viruses in every cell of their body.
Aswad A, Aimola G, Wight D, Roychoudhury P, Zimmermann C, Hill J, Lassner D, Xie H, Huang ML, Parrish NF, Schultheiss HP, Venturini C, Lager S, Smith GCS, Charnock-Jones DS, Breuer J, Greninger AL, Kaufer BB.   +17 more
europepmc   +6 more sources

Excision of Integrated Human Herpesvirus 6A Genomes Using CRISPR/Cas9 Technology. [PDF]

Microbiol Spectr, 2023
Human herpesviruses 6A and 6B are betaherpesviruses that can integrate their genomes into the telomeres of latently infected cells. Integration can also occur in germ cells, resulting in individuals who harbor the integrated virus in every cell of their ...
Aimola G, Wight DJ, Flamand L, Kaufer BB.   +3 more
europepmc   +3 more sources

Higher-Order Chromatin Structures of Chromosomally Integrated HHV-6A Predict Integration Sites. [PDF]

Front Cell Infect Microbiol, 2021
Human herpesvirus -6A and 6B (HHV-6A/B) can integrate their genomes into the telomeres of human chromosomes. Viral integration can occur in several cell types, including germinal cells, resulting in individuals that harbor the viral genome in every cell ...
Mariani M, Zimmerman C, Rodriguez P, Hasenohr E, Aimola G, Gerrard DL, Richman A, Dest A, Flamand L, Kaufer B, Frietze S.   +10 more
europepmc   +3 more sources

Unbiased optical mapping of telomere-integrated endogenous human herpesvirus 6. [PDF]

Proc Natl Acad Sci U S A, 2020
Next-generation sequencing technologies allowed sequencing of thousands of genomes. However, there are genomic regions that remain difficult to characterize, including telomeres, centromeres, and other low-complexity regions, as well as transposable ...
Wight DJ, Aimola G, Aswad A, Jill Lai CY, Bahamon C, Hong K, Hill JA, Kaufer BB.   +7 more
europepmc   +3 more sources