Results 51 to 60 of about 60,513 (316)

Health-related quality of life scores of metastatic pancreatic cancer patients responsive to first line chemotherapy compared to newly derived EORTC QLQ-C30 reference values

BMC Cancer, 2022
Background Metastatic pancreatic cancer (mPC) and its treatments significantly impact health-related quality of life (HRQoL). POLO, a randomized, double-blind, placebo-controlled phase 3 trial evaluated the efficacy of olaparib as maintenance therapy in ...
Suvina Amin, Seongjung Joo, Sandra Nolte, Hyun Kyoo Yoo, Nikunj Patel, Hilary F. Byrnes, Sara Costa-Cabral, Colin D. Johnson   +7 more
doaj   +1 more source

The iconicity toolbox: empirical approaches to measuring iconicity [PDF]

Language and Cognition, 2019
abstractGrowing evidence from across the cognitive sciences indicates that iconicity plays an important role in a number of fundamental language processes, spanning learning, comprehension, and online use. One benefit of this recent upsurge in empirical work is the diversification of methods available for measuring iconicity.
MOTAMEDI, Y, LITTLE, H, NIELSEN, A, SULIK, J   +3 more
openaire   +4 more sources

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Delphi Panel Consensus Statement Generation: COVID-19 Vaccination Recommendations for Immunocompromised Populations in the European Union

Infectious Diseases and Therapy
Introduction The coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare systems globally. The lack of quality guidelines on the management of COVID-19 in rheumatologic disease, renal disease, hematological malignancy,
Jaya Paranilam, Francesco Arcioni, Antonio Franco, Kira Zhi Hua Lai, Joseph Brown, Samantha Kimball-Carroll   +5 more
doaj   +1 more source

Good practices for the translation, cultural adaptation, and linguistic validation of clinician-reported outcome, observer-reported outcome, and performance outcome measures

Journal of Patient-Reported Outcomes, 2020
Within current literature and practice, the category of patient-reported outcome (PRO) measures has been expanded into the broader category of clinical outcome assessments (COAs), which includes the subcategory of PRO, as well as clinician-reported ...
Shawn McKown, Catherine Acquadro, Caroline Anfray, Benjamin Arnold, Sonya Eremenco, Christelle Giroudet, Mona Martin, Dana Weiss   +7 more
doaj   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Population pharmacokinetic modeling and simulation of maribavir to support dose selection and regulatory approval in adolescents with posttransplant refractory cytomegalovirus

CPT: Pharmacometrics & Systems Pharmacology, 2023
Maribavir was approved by the US Food and Drug Administration for the treatment of patients aged ≥12 years and weighing ≥35 kg with posttransplant cytomegalovirus infection/disease refractory (with/without resistance) to valganciclovir, ganciclovir ...
Kefeng Sun, Siobhan Hayes, Colm Farrell, Ivy H. Song   +3 more
doaj   +1 more source

Protein kinase FAM20C—when subcellular localization matters

FEBS Letters, EarlyView.
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley   +1 more source

We have a steak in it: Eliciting interventions to reduce beef consumption and its impact on biodiversity

Conservation Letters, 2020
Beef production is a major driver of biodiversity loss and greenhouse gas emissions globally, and multiple studies recommend reducing beef production and consumption.
Matthew J. Selinske, Fiona Fidler, Ascelin Gordon, Georgia E. Garrard, Alexander M. Kusmanoff, Sarah A. Bekessy   +5 more
doaj   +1 more source

Faktor Pemanfaatan Imunisasi Inactivated Polio Vaccine (IPV)

Jurnal Kesehatan, 2020
The low utilization of IPV immunization services in Palembang in 2017 was 66,7% while the national target was 95%. The purpose of this study was to determine the factors associated with the utilization of IPV immunization services in Palembang. The study
Icon Harizon, Misnaniarti Misnaniarti, Haerawati Idris   +2 more
doaj   +1 more source