Results 21 to 30 of about 243,754 (245)

Advances in Pathogenesis of Idiopathic Membranous Nephropathy [PDF]

Kidney Diseases, 2020
Background: Membranous nephropathy (MN), a major cause of nephrotic syndrome, has attracted people’s attention in recent years for its growing prevalence.
Zhifeng Xu, Lu Chen, Huiling Xiang, Chun Zhang, Jing Xiong   +4 more
doaj   +3 more sources

A retrospective study of calcineurin inhibitors in the treatment of idiopathic membranous nephropathy

Linchuang shenzangbing zazhi, 2015
Objective To observe the efficacy of calcineurin inhibitors in the treatment of the simple and the refractory idiopathic membranous nephropathy.Methods Seventy-two patients with idiopathic membranous nephropathy and regularly followed up in Changzheng ...
CUI Lin-lin, YE Chao-yang
doaj   +1 more source

Idiopathic Membranous Nephropathy [PDF]

Nephron, 2008
Idiopathic membranous nephropathy is still the most common glomerular disease associated with nephrotic syndrome. The greater the proteinuria, the greater the long-term risk for renal failure. In addition, patients who have membranous nephropathy with nephrotic syndrome have significant morbidity and mortality, in particular related to thromboembolic ...
A M, Pierides, D N, Kerr
  +6 more sources

Animal models of idiopathic membranous nephropathy: Recent advances and future perspectives. [PDF]

Animal Model Exp Med
This review focuses on the evolution of idiopathic membranous nephropathy (IMN) animal models from traditional approaches (Heymann nephritis, C‐BSA, APA) to antigen‐specific models (PLA2R, THSD7A), critically evaluating their advances and limitations in replicating human IMN pathology.
Liu Q, Bian H, Liu J, Wu L, Zhang Z, Zhao H, Qin X.   +6 more
europepmc   +2 more sources

Rituximab in Idiopathic Membranous Nephropathy [PDF]

Journal of the American Society of Nephrology, 2012
Selective depletion of B cells with the mAb rituximab may benefit the autoimmune glomerular disease idiopathic membranous nephropathy (IMN). Here, we describe our experience treating 100 consecutive IMN patients with persistent nephrotic syndrome with rituximab. We defined complete remission as persistent proteinuria
P. Ruggenenti, P. Cravedi, A. Chianca, A. Perna, B. Ruggiero, F. Gaspari, A. Rambaldi, M. Marasà, G. Remuzzi   +8 more
openaire   +3 more sources

Case Report: Coexistence of Anti-Glomerular Basement Membrane Disease, Membranous Nephropathy, and IgA Nephropathy in a Female PatientWith Preserved Renal Function

Frontiers in Pharmacology, 2022
The coexistence of anti-glomerular basement membrane (GBM) disease, idiopathic membranous nephropathy (IMN), and IgA nephropathy in one patient is a very rare case, which has not yet been reported.
Wei Qu, Nan Liu, Tianhua Xu, Binyao Tian, Meng Wang, Yanqiu Li, Jianfei Ma, Li Yao   +7 more
doaj   +1 more source

Single-cell RNA sequencing shows the immune cell landscape in the kidneys of patients with idiopathic membranous nephropathy

Frontiers in Immunology, 2023
Idiopathic membranous nephropathy (IMN) is a leading pathological type of the adult primary nephrotic syndrome. Some patients develop end-stage renal disease due to poor response to treatment with steroid and immunosuppressive agents. In order to explore
Manman Shi, Yu-Xin Wang, Huan Zhang, Zi-Cheng Ling, Xue Chen, Chao-Jun Wang, Jian Liu, Yuhua Ma   +7 more
semanticscholar   +1 more source

Risk HLA-DQA1 and PLA2R1 alleles in idiopathic membranous nephropathy [PDF]

, 2011
Background: Idiopathic membranous nephropathy is a major cause of the nephrotic syndrome in adults, but its etiologic basis is not fully understood. We investigated the genetic basis of biopsy-proven cases of idiopathic membranous nephropathy in a white ...
Heijer, M. den, P. Brenchley (7619294), Coenen, MJH, Pierre Ronco, A. Zawadzka (7619276), Brenchley, Paul; id_orcid, V. Laundy (7619273), Stephens, H.A.F., Detlef Bockenhauer, Hanna Debiec, Voinescu, C., Voinescu, C, Kerra Pearce, Feehally, John, Medlar, A, Kiemeney, L.A.L.M., Ronco, P, Kottgen, A, Bockenhauer, D., Anna Kottgen, Patel, N., Horia C. Stanescu, Debiec, Hanna, Arcos-Burgos, M., S. Padmanabhan (637530), H. Debiec (7619300), J. Feehally (7584482), Laundy, Valerie, Coenen, Marieke J H, Valerie Laundy, P. W. Mathieson (7619309), Stanescu, Horia C., Hubank, Mike, Ronco, P., Stephen H. Powis, Laundy, V, Bockenhauer, Detlef, Benedicte Stengel, Coenen, M.J.H., Feehally, J., D. Bockenhauer (7619252), Stephens, HA, Wetzels, JFM, Kottgen, A., Brenchley, P, Kleta, R, Stanescu, HC, Mathieson, Peter W., Powis, S.H., J. M. Hofstra (7619279), Martin den Heijer, L. Dragomirescu (7619258), Hubank, M., Stengel, Benedicte, Rees, A.J., Mathieson, PW, Delphine Bacq-Daian, A. Medlar (7619249), Den Heijer, M, Debiec, H, M. den Heijer (7583045), Wetzels, JF, P. Ronco (7619306), Stanescu, H.C., H. A. Stephens (7619270), Bacq-Daian, D, Stephens, HAF, M. Hubank (7619267), Arcos-Burgos, M, Stephens, Henry A F, Liviu Dragomirescu, Naina Patel, Mathieson, P.W., Jack F.M. Wetzels, Padmanabhan, S, Arcos-Burgos, Mauricio, Laundy, V., Zawadzka, A, J. F. Wetzels (7619303), Medlar, A., Alan Medlar, Lambertus A.L.M. Kiemeney, Wetzels, J.F.M., B. Stengel (1741084), M. J. Coenen (7619282), Bacq-Daian, Delphine, H. C. Stanescu (7619246), N. Patel (1363386), Powis, SH, Coenen, MJ, M. Arcos-Burgos (5038694), Paul Brenchley, C. Voinescu (7619261), Kottgen, Anna, Andrew J. Rees, Hofstra, Julia M., John Feehally, Patel, Naina, Marieke J.H. Coenen, Kiemeney, LALM, Anna Zawadzka, Brenchley, P., Mauricio Arcos-Burgos, Debiec, H., Pearce, Kerra, Padmanabhan, S., Den Heijer, Martin, Mike Hubank, Bockenhauer, D, Stengel, B, Hofstra, J.M., L. A. Kiemeney (7619285), A. J. Rees (7619297), Kiemeney, Lambertus A L M, Julia M. Hofstra, Dragomirescu, L., Stephens, H.A., Padmanabhan, Sandosh, S. H. Powis (7619291), Kleta, R., Pearce, K., Hubank, M, Dragomirescu, Liviu, A. Kottgen (7619255), Ronco, Pierre, Robert Kleta, R. Kleta (7619312), Zawadzka, Anna, Catalin Voinescu, Henry A.F. Stephens, Bacq-Daian, D., Dragomirescu, L, Medlar, Alan, Wetzels, Jack F M, K. Pearce (7619264), den Heijer, M., Rees, Andrew J., Peter W. Mathieson, Zawadzka, A., Sandosh Padmanabhan, D. Bacq-Daian (7619288), Rees, AJ, Voinescu, Catalin, Pearce, K, Kleta, Robert, Feehally, J, Stengel, B., Powis, Stephen H., Hofstra, JM, Kiemeney, LA, Patel, N   +150 more
core   +4 more sources

Metformin combined with rapamycin ameliorates podocyte injury in idiopathic membranous nephropathy through the AMPK/mTOR signaling pathway

Journal of cell communication and signaling, 2023
Autophagy activation protects against podocyte injury in idiopathic membranous nephropathy (IMN). The AMPK/mTOR signaling pathway is a vital autophagy regulatory pathway. Metformin promotes autophagy, whereas rapamycin is an autophagy agonist.
Mei-Chen Ma, Yue Pan, Yue Zhang, Mei Yang, Ying Xi, Baoxu Lin, Wudi Hao, Jian-Hua Liu, Lina Wu, Yong Liu, Xiao-Song Qin   +10 more
semanticscholar   +1 more source

Treatment of Idiopathic Membranous Nephropathy [PDF]

Journal of the American Society of Nephrology, 2012
Exciting progress recently has been made in our understanding of idiopathic membranous nephropathy, as well as treatment of this disease. Here, we review important advances regarding the pathogenesis of membranous nephropathy. We will also review the current approach to treatment and its limitations and will highlight new therapies that are currently ...
Meryl, Waldman, Howard A, Austin
openaire   +2 more sources