Results 1 to 10 of about 18,680 (231)

Adverse pro-tumorigenic effects of IDO1 catalytic inhibitors mediated by the non-enzymatic function of IDO1 in tumor cells

Frontiers in Immunology
Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors have been developed with the aim of reinvigorating antitumor T-cell responses in the tumor microenvironment by blocking the conversion of the essential amino acid tryptophan into immunoregulatory ...
Daniele Sorcini, Sara Ambrosino
exaly   +7 more sources

Nanodelivery Optimization of IDO1 Inhibitors in Tumor Immunotherapy: Challenges and Strategies [PDF]

International Journal of Nanomedicine
Kehua Jiang,1 Qing Wang,1 Xiao-Long Chen,1 Xiaodong Wang,1 Xiaoya Gu,1 Shuangshuang Feng,1 Jian Wu,2 Haojie Shang,2 Xiaozhuo Ba,2 Yanlong Zhang,1 Kun Tang2 1Department of Urology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, People’s Republic ...
Kun Tang, Qing Wang, Yanlong Zhang
exaly   +3 more sources

IDO1 mRNA upregulation was associated with gene body hypermethylation and poor overall survival in esophageal squamous cell carcinoma

Archives of Medical Science, 2021
Introduction This study aimed to explore the potential genetic and epigenetic mechanisms associated with IDO1 mRNA dysregulation in esophageal cancer (ESCA).
Chang-Qing Zhang, Xue-Bin Wang, Shu-Ping Li, Guo-Ying Miao, Rong Wang, Wen Ma   +5 more
doaj   +2 more sources

Discovery of Novel 1,2,3-triazole Derivatives as IDO1 Inhibitors

Pharmaceuticals, 2022
Indoleamine 2,3-dioxygenase 1 (IDO1) has received much attention as an immunomodulatory enzyme in the field of cancer immunotherapy. While several IDO1 inhibitors have entered clinical trials, there are currently no IDO1 inhibitor drugs on the market. To
Xixi Hou, Xiaoqing Gong, Longfei Mao, Jie Zhao, Jianxue Yang   +4 more
doaj   +2 more sources

A Novel IDO1/NE Dual Inhibitor, IMM-H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression. [PDF]

Adv Sci (Weinh)
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Zhou Y, Zhao X, Pan X, Ma Z, Cui H, Wen H, Wang P, Liao X, Qin K, Wang Y, Sheng L, Zhang S.   +11 more
europepmc   +2 more sources

Tryptophan metabolism in colorectal cancer: From mechanistic insights to novel therapeutic strategies. [PDF]

Clin Transl Med
Tryptophan metabolism modulates CRC via three microbiota‐regulated pathways with distinct dual‐mode effects. The kynurenine pathway provides biomarkers, serotonin pathway supports SSRI‐combined immunotherapy, indole pathway yields immunostimulatory metabolites, collectively offering translational prospects.
Wang R, Shen W, Yang P, Yang D, Cao Y, Zhou Y.   +5 more
europepmc   +2 more sources

H2S induces apoptosis of tumors with high IDO1 expression via NR4A1-BCL-2 and SOCS3 pathways [PDF]

Cellular & Molecular Biology Letters
Background Hydrogen sulfide (H2S) has been reported to exert both protumor and antitumor functions. It is worthy to clarify the condition under which H2S exerts antitumor effects and its underlying mechanism.
Zhen Ning Tony He, Fangzhou Meng, Xiaoyang Qian, Yuying Liu, Xin Fang, Dan Yang, Qing Yang   +6 more
doaj   +2 more sources

Cancer IDO1‐Mediated Tryptophan–Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration [PDF]

Journal of Cachexia, Sarcopenia and Muscle
Background Cancer cachexia is a debilitating syndrome characterized by severe skeletal muscle wasting, which significantly impairs patient quality of life and survival. Indoleamine 2,3‐dioxygenase 1 (IDO1), a key enzyme in tryptophan (Trp) metabolism, is
Leng Han, Lingjie Jing, Xinting Zhu, Ciqin Li, Lu Bai, Yang Fang, Yuxuan Zhou, Dingyuan Bai, Jin Lu, Yonglong Han, Cheng Guo, Shumin Zhou, Quanjun Yang   +12 more
doaj   +2 more sources

Epacadostat stabilizes the apo-form of IDO1 and signals a pro-tumorigenic pathway in human ovarian cancer cells

Frontiers in Immunology
The tryptophan-degrading enzyme indoleamine 2,3-dioxygenase 1 (IDO1) is a plastic immune checkpoint molecule that potently orchestrates immune responses within the tumor microenvironment (TME).
Maria Laura Belladonna, Antonio Macchiarulo, Maria Teresa Pallotta   +2 more
exaly   +3 more sources

Kynurenine: an oncometabolite in colon cancer

Cell Stress, 2020
Tryptophan is one of the eight essential amino acids that must be obtained from the diet. Interestingly, tryptophan is the least abundant amino acid in most proteins, a large portion of cellular tryptophan is converted into metabolites of the serotonin ...
Niranjan Venkateswaran, Maralice Conacci-Sorrell   +1 more
doaj   +1 more source