Results 11 to 20 of about 18,680 (231)
IDO1 is an Integral Mediator of Inflammatory Neovascularization [PDF]
EBioMedicine, 2016 The immune tolerogenic effects of IDO1 (indoleamine 2,3-dioxygenase 1) have been well documented and genetic studies in mice have clearly established the significance of IDO1 in tumor promotion. Dichotomously, the primary inducer of IDO1, the inflammatory cytokine IFNγ (interferon-γ), is a key mediator of immune-based tumor suppression.
Mondal, Arpita +6 more
core +6 more sources
IDO1 Promotes the Progression of NSCLC by Regulating the Polarization of M2 Macrophages
International Journal of General Medicine, 2023 Xiao Chen,1,2 Jie Yao,1 Meng-Yu Zhang,1 Rui Li,1 Xiao Liu,1 Yi-Qing Qu1 1Department of Pulmonary and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 2Department of Respiratory Medicine, Tai’an City Central
Chen X +5 more
doaj +1 more source
IDO1 (indoleamine 2,3-dioxygenase 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on IDO1 (indoleamine 2,3-dioxygenase 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Chang, MY, Muller, AJ, Prendergast, GC
openaire +4 more sources
Investigating the role of IDO1 in tumors: correlating IDO1 expression with clinical pathological features and prognosis in lung adenocarcinoma patients [PDF]
PeerJPurpose This study aimed to investigate the role and expression patterns of IDO1 in various tumors, focusing on its correlation with clinical pathological characteristics and prognosis in patients specifically diagnosed with lung adenocarcinoma.
Yin, Zhidong +6 more
openaire +4 more sources
AhR-Mediated, Non-Genomic Modulation of IDO1 Function [PDF]
Frontiers in Immunology, 2014 The evolutionary process has conferred a dual - enzymatic and signaling - function on the ancestral metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1), which has long been known for converting the essential amino acid tryptophan (TRP) into neuroactive and immunoactive catabolites (kynurenines).
PALLOTTA, MARIA TERESA +4 more
openaire +6 more sources
Прогностическая значимость экспрессии CD204 и IDO1 в опухолях пищевода [PDF]
, 2021 Introduction. Cancer of the esophagus ranks sixth in mortality among malignant neoplastic diseases. To understand the molecular mechanisms of its progression, it is necessary to study not only tumor cells directly, but also cells of the microenvironment.
М. А. Рашидова +11 more
core +1 more source
Immunological Relevance of the Coevolution of IDO1 and AHR [PDF]
Frontiers in Immunology, 2014 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified because of its role in controlling the cellular response to environmental molecules. More recently, AHR has been shown to play a crucial role in controlling innate and adaptive immune responses through several mechanisms, one of which is the regulation ...
Jaronen, Merja, Quintana, Francisco
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Inhibition Mechanisms of Indoleamine 2,3-Dioxygenase 1 (IDO1)
, 2019 Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the rate-limiting step in the kynurenine pathway of tryptophan metabolism, which is involved in immunity, neuronal function, and aging.
Pierre Vogel (1856911) +5 more
core +4 more sources
Signal Transduction and Targeted Therapy, 2022 Indoleamine 2,3-dioxygenase 1 (IDO1), the enzyme that catabolizes tryptophan (Trp) metabolism to promote regulatory T cells (Tregs) and suppress CD8+ T cells, is regulated by several intrinsic signaling pathways.
Fan Liang +18 more
doaj +1 more source
Indoleamine-2,3-Dioxygenase 1 Deficiency Suppresses Seizures in Epilepsy
Frontiers in Cellular Neuroscience, 2021 Background: Indoleamine-2,3-dioxygenase 1 (IDO1) is the initial and rate-limiting enzyme in the metabolism of tryptophan (TRP) to kynurenine (KYN).
Ning Deng +10 more
doaj +1 more source