Results 41 to 50 of about 18,680 (231)
Cell‐Based Identification of New IDO1 Modulator Chemotypes [PDF]
Angewandte Chemie, 2021 AbstractThe immunoregulatory enzyme indoleamine‐2,3‐dioxygenase (IDO1) strengthens cancer immune escape, and inhibition of IDO1 by means of new chemotypes and mechanisms of action is considered a promising opportunity for IDO1 inhibitor discovery. IDO1 is a cofactor‐binding, redox‐sensitive protein, which calls for monitoring of IDO1 activity in its ...
Elisabeth Hennes +7 more
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A possible IDO1- TSP1 role in breast cancer dormancy [PDF]
Disseminated breast cancer cells have been found in the perivascular niche of lung, brain and bone marrow. Research has suggested that thrombospondin 1 (TSP1), an antiangiogenic protein secreted by endothelial cells, is involved in cancer dormancy.
Lopes Bastos, Bruno
core +6 more sources
OncoImmunology, 2017 Kynurenine formation by tryptophan-catabolic indoleamine-2,3-dioxygenase 1 (IDO1) plays a key role in tumor immune evasion and inhibition of IDO1 is efficacious in preclinical models of breast cancer. As the response of breast cancer to immune checkpoint
Dyah L. Dewi +21 more
doaj +1 more source
Discovery of IDO1 Inhibitors: From Bench to Bedside [PDF]
Cancer Research, 2017 AbstractSmall-molecule inhibitors of indoleamine 2,3-dioxygenase-1 (IDO1) are emerging at the vanguard of experimental agents in oncology. Here, pioneers of this new drug class provide a bench-to-bedside review on preclinical validation of IDO1 as a cancer therapeutic target and on the discovery and development of a set of mechanistically distinct ...
George C, Prendergast +3 more
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Pharmaceuticals, 2022 Indoleamine 2, 3-dioxygenase 1 (IDO1) is commonly expressed by cancers as a mechanism for evading the immune system. Preclinical and clinical studies have indicated the potential of combining IDO1 inhibitors with immune therapies for the treatment of ...
Sofian M Tijono +7 more
doaj +1 more source
The Role and Mechanism of S1PR5 in Colon Cancer
Cancer Management and Research, 2020 Huijun Zhou,1 Xianli Yin,2 Fei Bai,3 Wu Liu,2 Shaofeng Jiang,2 Jinfeng Zhao1 1Key Laboratory of Nanobiological Technology of National Health Commission of China, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of ...
Zhou H +5 more
doaj
Cells, 2022 Gamma-interferon (γ-IFN) significantly inhibits infection by replication-defective viral vectors derived from the human immunodeficiency virus type 1 (HIV-1) or murine leukemia virus (MLV) but the underlying mechanism remains unclear. Previously we reported that knockdown of γ-IFN-inducible lysosomal thiolreductase (GILT) abrogates the antiviral ...
Yoshinao Kubo +4 more
openaire +3 more sources
, 2022 Indoleamine 2, 3-dioxygenase 1 (IDO1) is an immunomodulatory enzyme that catalyzes the degradation of tryptophan to kynurenine and induces immune tolerance in tumor cells.
Moonho Kim +13 more
core +1 more source
Protective effects of sumatriptan against optic nerve injury in rats via modulation of kynurenine pathway, oxidative stress and apoptosis [PDF]
BioImpactsIntroduction: Traumatic optic neuropathy (TON) is an acute visual dysfunction subsequent to head and neck trauma. Despite immense efforts, there is no effective treatment to minimize the damage caused by TON.
Moein Ala +7 more
doaj +1 more source
Frontiers in Immunology, 2021 Indoleamine 2,3-dioxygenase (IDO1) is a key regulator of immune suppression by catalyzing the oxidation of L-tryptophan. IDO1 expression has been related to poor prognosis in several cancers and to resistance to checkpoint immunotherapies.
Yvonne Grobben +16 more
doaj +1 more source