Results 51 to 60 of about 18,680 (231)

Elevated IDO1 expression distinguishes basal-like human breast cancer.

, 2022
Patients diagnosed with basal-like breast cancer face a more aggressive disease course and more dismal prognosis than patients diagnosed with luminal A and luminal B breast cancer molecular subtypes (1-4).
Shahan Mamoor
core   +1 more source

H2S suppresses indoleamine 2, 3-dioxygenase 1 and exhibits immunotherapeutic efficacy in murine hepatocellular carcinoma

Journal of Experimental & Clinical Cancer Research, 2019
Background Over-expression and over-activation of immunosuppressive enzyme indoleamine 2, 3 -dioxygenase 1 (IDO1) is a key mechanism of cancer immune escape. However, the regulation of IDO1 has not been fully studied.
Dan Yang, Tianqi Li, Yinlong Li, Shengnan Zhang, Weirui Li, Heng Liang, Zikang Xing, Lisha Du, Jinchao He, Chunxiang Kuang, Qing Yang   +10 more
doaj   +1 more source

Preclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma

OncoImmunology, 2017
Glioblastoma (GBM) is resistant to most multimodal therapies. Clinical success of immune-checkpoint inhibitors (ICIs) has spurred interest in applying ICIs targeting CTLA4, PD1 or IDO1 against GBM.
Abhishek D. Garg, Lien Vandenberk, Matthias Van Woensel, Jochen Belmans, Marco Schaaf, Louis Boon, Steven De Vleeschouwer, Patrizia Agostinis   +7 more
doaj   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

The Role and Mechanism of S1PR5 in Colon Cancer [Retraction]

Cancer Management and Research, 2021
Zhou H, Yin X, Bai F, Liu W, Jiang S, Zhao J. Cancer Manag Res. 2020;12:4759—4775. The Editor-in-chief and Publisher of Cancer Management and Research wish to retract the published article.
Zhou H, Yin X, Bai F, Liu W, Jiang S, Zhao J   +5 more
doaj  

IDO Expression in Cancer: Different Compartment, Different Functionality?

Frontiers in Immunology, 2020
Indoleamine 2,3-dioxygenase 1 (IDO1) is a cytosolic haem-containing enzyme involved in the degradation of tryptophan to kynurenine. Although initially thought to be solely implicated in the modulation of innate immune responses during infection ...
Annabel Meireson, Annabel Meireson, Michael Devos, Lieve Brochez, Lieve Brochez   +4 more
doaj   +1 more source

Indoleamine 2, 3 Dioxygenase 1 Impairs Chondrogenic Differentiation of Mesenchymal Stem Cells in the Joint of Osteoarthritis Mice Model

Frontiers in Immunology, 2021
Osteoarthritis (OA) is a serious joint inflammation that leads to cartilage degeneration and joint dysfunction. Mesenchymal stem cells (MSCs) are used as a cell-based therapy that showed promising results in promoting cartilage repair.
Murad Alahdal, Murad Alahdal, Rongxiang Huang, Li Duan, Deng Zhiqin, Ouyang Hongwei, Wencui Li, Daping Wang, Daping Wang   +8 more
doaj   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy [PDF]

, 2018
Tumors use indoleamine 2,3-dioxygenase-1 (IDO1) as a major mechanism to induce an immunosuppressive microenvironment. IDO1 expression is upregulated in many cancers and considered to be a resistance mechanism to immune checkpoint therapies.
Gomes, Bruno, Tumang, J, Marillier, Reece, Bartlett, Derek, Driessens, G, Rabolli, Virginie, Wythes, M, Van den Eynde, Benoit J, Dillon, Christopher P, Tumang, Joseph, Gomes, B, Fantin, VR, Pirson, R, Fantin, Valeria R., van den Eynde, BJ, Cai, D, Dalvie, Deepak, Van den Eynde, Benoît, Dillon, CP, Bartlett, D, Crosignani, S, Kraus, M, Streiner, N, Torti, Vince R, Zheng, Xianxian, Denies, S, Tsaparikos, Konstantinos, Torti, Vince R., Maegley, KA, Cauwenberghs, Sandra, Kraus, Manfred, Yao, L-C, Dillon, Christopher P., Letellier, M-C, Cai, Danying, Crosignani, Stefano, Zheng, X, Rabolli, V, Driessens, Gregory, Guo, J, Pirson, Romain, Dalvie, D, Marillier, R, Ray, Chad, Guo, Jie, Miller, Nichol, Cauwenberghs, S, Letellier, Marie-Claire, Denies, Sofie, Wythes, Martin, Tsaparikos, K, Li, Wenlin, Fantin, Valeria R, Miller, N, Yao, Li-Chin, Streiner, Nicole, Torti, VR, Li, W, Maegley, Karen, Ray, C   +59 more
core   +1 more source