Results 71 to 80 of about 18,680 (231)
, 2016 Indoleamine 2,3-dioxygenase 1 (IDO1), promoting immune escape of tumors, is a therapeutic target for the cancer immunotherapy. A number of IDO1 inhibitors have been identified, but only limited structural biology studies of IDO1 inhibitors are available ...
Ming-Shiu Hung (1435009) +18 more
core +3 more sources
Ketogenic diet for infantile epileptic spasms
Epilepsia Open, EarlyView.Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury +3 more
wiley +1 more source
EBioMedicine, 2019 Background: The immune checkpoint, indoleamine 2,3-dioxygenase 1, is under investigation as target of novel immunotherapies for cancers, including head and neck squamous cell carcinomas (HNSCC).
Verena Sailer +16 more
doaj +1 more source
The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity
Epilepsia Open, EarlyView.Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia +4 more
wiley +1 more source
Serotonin neuromicrobiology: Psychobiotic modulation of the gut–brain axis for mental health
Ibrain, EarlyView.An overview of Psychobiotics and Tryptophan metabolism: A serotonin‐kynurenine crosstalk shaping the Gut‐Brain axis. IDO1, Indoleamine 2,3‐dioxygenase 1; 5‐HT3, 5‐hydroxytryptamine type 3; IFN‐γ, Interferon‐gamma; TNF‐α, Tumor necrosis factor‐alpha; IL‐1β, Interleukin‐1 beta; IL‐6, Interleukin 6; Trp, Tryptophan; 5‐HT, 5‐hydroxy‐tryptamine; 5‐HTP, 5 ...
Nidhi Mandloi +4 more
wiley +1 more source
结直肠肛门外科[Objectives] To investigate the relationship between the expression of PD-1, PD-L1, and IDO1 and microsatellite instability (MSI) status in the tumor microenvironment of colorectal cancer (CRC).
Wang Ya’nan +5 more
doaj +1 more source
Advances in Immunological Combination Therapy for Colorectal Cancer
iMetaMed, EarlyView.Review the progress of combined immunotherapy for colorectal cancer. ABSTRACT Immune checkpoint inhibitors (ICIs) have been utilized extensively and shown to be therapeutically beneficial in the treatment of solid tumors in recent years. Nonetheless, considerable heterogeneity in Colorectal cancer (CRC) requires careful consideration.
Jiayue Wu +7 more
wiley +1 more source
Amyloid β neurotoxicity is IDO1–Kyn–AhR dependent and blocked by IDO1 inhibitor [PDF]
Signal Transduction and Targeted Therapy, 2020 Duan, Zhenzhen +9 more
openaire +2 more sources
iMetaMed, EarlyView.Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine associated with an imbalance in intestinal homeostasis. m6A‐modifying enzymes, consisting of m6A writers, erasers and readers, plays a pivotal role in the pathogenesis and progression of IBD by affecting four intestinal barriers, including the intestinal mechanical ...
Jiaxian Guo +4 more
wiley +1 more source
Effect of galanal on IDO1 activity in different cell species.
, 2014 HEK 293 cells transfected with human IDO1 (A) or mouse IDO1 (B) were treated with various concentrations (1-5 µM) of galanal for 48 hrs.
Yasuko Yamamoto (522533) +7 more
core +1 more source