Results 91 to 100 of about 18,680 (231)

IDO1 Expression in Melanoma Metastases Is Low and Associated With Improved Overall Survival

, 2020
Indoleamine 2–3 dioxygenase 1 (IDO1) expression may contribute to immunologic escape by melanoma metastases. However, a recent clinical trial failed to identify any clinical benefits of IDO1 inhibition in patients with unresectable metastatic melanoma ...
Kwak, Minyoung, Lynch, Kevin T., Wages, Nolan A., Craig L. Slingluff, Kevin T. Lynch, Max O. Meneveau, Alejandro A. Gru, Gradecki, Sarah E., Meneveau, Max O., Sarah E. Gradecki, Nolan A. Wages, Slingluff, Craig L., Gru, Alejandro A., Minyoung Kwak   +13 more
core   +1 more source

Comprehensive behavioral analysis of indoleamine 2,3‐dioxygenase knockout mice

Neuropsychopharmacology Reports, 2018
Aim Indoleamine 2,3‐dioxygenase 1 (IDO1) metabolizes the essential amino acid tryptophan into kynurenine derivatives, which are involved in neural activity via the kynurenine pathway (KP).
Nao Hirata, Satoko Hattori, Hirotaka Shoji, Hiroshi Funakoshi, Tsuyoshi Miyakawa   +4 more
doaj   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors

Frontiers in Immunology, 2015
The tryptophan (TRP) to kynurenine (KYN) metabolic pathway is now firmly established as a key regulator of innate and adaptive immunity. A plethora of preclinical models suggests that this immune tolerance pathway - driven by the key and rate-limiting enzymes indoleamine-2,3-dioxygenase and TRP-2,3-dioxygenase - is active in cancer immunity ...
Platten, Michael, von Knebel Doeberitz, Nikolaus, Oezen, Iris, Wick, Wolfgang, Ochs, Katharina   +4 more
openaire   +3 more sources

High indoleamine 2,3-dioxygenase transcript levels predict better outcome after front-line cancer immunotherapy

iScience
Summary: Indoleamine 2,3-dioxygenase 1 (IDO1), which catabolizes tryptophan, is a potential target to unlock the immunosuppressive tumor microenvironment. Correlations between IDO1 and immune checkpoint inhibitor (ICI) efficacy remain unclear. Herein, we
Yu Fujiwara, Shumei Kato, Daisuke Nishizaki, Hirotaka Miyashita, Suzanna Lee, Mary K. Nesline, Jeffrey M. Conroy, Paul DePietro, Sarabjot Pabla, Scott M. Lippman, Razelle Kurzrock   +10 more
doaj   +1 more source

KYNU in Gastric Cancer Cells Promotes Tumor Progression by Influencing Macrophage Polarization Via PF4

Cancer Science, EarlyView.
KYNU is upregulated in gastric cancer cells and activates the PI3K/Akt pathway, leading to PF4 secretion. PF4 drives nonclassical macrophage polarization with high expression of S100A8 and MMP7, which promotes tumor proliferation, migration, and invasion while suppressing phagocytosis, thereby accelerating gastric cancer progression.
Xilun Cui, Changfeng Li, Yuanda Liu, Chang Liu, Wei Yang   +4 more
wiley   +1 more source

Overexpression of Indoleamine 2,3-Dioxygenase 1 Promotes Epithelial-Mesenchymal Transition by Activation of the IL-6/STAT3/PD-L1 Pathway in Bladder Cancer

Translational Oncology, 2019
Indoleamine 2,3-dioxygenase 1 (IDO1) is a key enzyme in tryptophan metabolism and plays an important role in tumor cell immunosuppression and angiogenesis.
Wentao Zhang, Junfeng Zhang, Ziwei Zhang, Yadong Guo, Yuan Wu, Ruiliang Wang, Longsheng Wang, Shiyu Mao, Xudong Yao   +8 more
doaj   +1 more source

Lung Cancer Brain Metastasis: Brain Microenvironmental Adaptation, Therapeutic Resistance and Translational Strategies

Cancer Science, EarlyView.
Lung cancer brain metastasis is shaped by dynamic crosstalk among tumor cells, the blood–brain barrier, glial and immune cells, neurons, and metabolic niches. This review integrates these mechanisms with therapeutic resistance, translational models, CNS delivery, and multidisciplinary treatment strategies.
Jun Yang, Junyi Xiong, Li Ying, Yanyang Zeng, Ziqiang Ouyang, Mei Liu, Meihua Li   +6 more
wiley   +1 more source

The list of published IDO1 inhibitor.

, 2014
The list of published IDO1 inhibitor.
Yasuko Yamamoto (522533), Shinjiro Imai (512471), Ryuta Fukutomi (522534), Yushi Matuo (522537), Kuniaki Saito (9421), Yoshio Ozawa (522535), Masako Abe (522536), Rie Yamamoto (522532)   +7 more
core   +1 more source

Prognostic and immune correlation of IDO1 promoter methylation in breast cancer

Scientific Reports
Indoleamine 2,3-dioxygenase 1 (IDO1) plays an important role in the initiation and progression of breast cancer. DNA promoter methylation status has the potential to be used as a biomarker for predicting the response to immunotherapy. This study aimed to
Shirong Ding, Ruozhu Yang, Jiahao Meng, Xinyu Guan, Yue Hong, Jiachi Xu, Limeng Qu, Jingfen Ji, Wenjun Yi, Qiongyan Zou, Qian Long   +10 more
doaj   +1 more source