Results 61 to 70 of about 18,680 (231)

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source

대장염 모델 Ido1-/- 마우스에서의 장내 미생물체 분석 [PDF]

, 2014
학위논문 (석사)-- 서울대학교 대학원 : 식품영양학과, 2014. 8. 신동미.차세대 염기서열 분석 기법이 발달함에 따라 인간과 공생하는 미생물에 관한 연구가 활발히 연구되고 있다. 특히 다른 기관에 비해 장내에는 매우 다양한 미생물들이 존재하고 있으며, 숙주의 면역체계와 긴밀한 상호관계를 맺고 있음이 알려져 있다.
신지희
core  

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Chronic Stress Promotes Gastric Cancer Metastasis by Inducing Microbiota‐Associated Kynurenine Accumulation and Macrophage Remodeling

Advanced Science, EarlyView.
Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao, Zhiyuan Song, Jingcheng Zhang, Jiaheng Lou, Shuo Zhang, Boqiang Liu, Yunhai Wei, Fengmei Qiu, Tao Jiang, Guangji Zhang   +9 more
wiley   +1 more source

Evaluation of mode of indoleamine 2,3-dioxygenase 1 inhibition by 4,7-dichloroquinolines

European Journal of Medicinal Chemistry Reports, 2023
Herein, we report the development of synthetically simpler analogs of 4,7-dichloroquinoline (DCQ) as apo-indoleamine 2,3-dioxygenase 1(IDO1) protein targeting ligand to inhibit the activity of IDO1 enzyme.
Niku Moni Das, Biswa Mohan Prusty, Nirmalya Pradhan, Anjali Gupta, Miguel Carmena-Bargueño, Rama Karn, Horacio Pérez-Sánchez, Sachin Kumar, Debasis Manna   +8 more
doaj   +1 more source

Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading

Advanced Science, EarlyView.
Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong, Elen Zhu, Min Seo Kang, Ming Wang, Sam Comito, Chang H. Lee   +5 more
wiley   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Expression of IDO1 in rat spleen.

, 2013
Analysis of the IDO1-gene expression in spleens from four Wistar rats treated with daily i.p. injections of Zebularine (225 mg/kg/day, two rats) or PBS (two rats) for 7 days.
Henrietta Nittby (450457), Karolina Förnvik (450459), Susanne Strömblad (450460), Peter Ericsson (450458), Gunnar Skagerberg (450463), Linda Jansson (450461), Leif G. Salford (255632), Zhongtian Xue (450462), Bengt Widegren (255631), Hans-Olov Sjögren (450464)   +9 more
core   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

TMIC-14. A novel IDO1 PROTAC decreases immunosuppressive extracellular IDO1 levels

Neuro-Oncology
Abstract BACKGROUND Indoleamine 2,3-dioxygenase 1 (IDO1) is an immunosuppressive enzyme expressed in >90% of patient-resected glioblastoma (GBM). IDO1 expression is inversely correlated with GBM patient survival. Extracellular IDO1 contributes to IDO1-mediated immunosuppression.
Bommi, Prashant V, Koch, Taylor, Jha, Sonam V, King, Kellen, Penco-Campillo, Manon, Lauing, Kristen L, Odum, Oluwatomilayo, Zhai, Lijie, Anderson, Douglas, Germanwala, Anand, Prabhu, Vikram, Thakkar, Jigisha, Yamini, Bakhtiar, Lukas, Rimas, Schiltz, Gary E, Wainwright, Derek A   +15 more
openaire   +1 more source