Results 121 to 130 of about 4,006,149 (207)

Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

Since the discovery of indoleamine 2,3-dioxygenase 1 (IDO1) as an attractive target for anticancer therapy in 2003, the search for inhibitors has been intensely pursued both in academia and in pharmaceutical companies. Many novel IDO1 inhibitor scaffolds
Roehrig, Ute F., Michiein, Olivier, Zoete, Vincent, Majjigapu, Somi Reddy, Vogel, Pierre   +4 more
core   +1 more source

Qingfei mixture mitigates immunosuppression of tumor microenvironment in non-small cell lung cancer by blocking stat1/Ido1-mediated tryptophan-kynurenine pathway

Heliyon
Programmed death-1 (PD-1) acts as a T cell checkpoint and is important in controlling T cell exhaustion. Blocking the intercommunication across PD-1 and PD-L1 is promising for advanced lung cancer treatment.
Zhuo Chen, Yu-Heng Ding, Lan Shao, Xu-Ming Ji, Xiang Qian, Ai-Qin Zhang   +5 more
doaj   +1 more source

Unraveling the Anti‐Arthritic Potential of Bioactive Compounds From Melaleuca alternifolia Oil: Integrated In Vivo, Molecular Docking, and Network Pharmacology Insights

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Melaleuca alternifolia oil demonstrated significant anti‐arthritic effects in CFA‐induced rats by reducing paw edema, PGE2 levels, and inflammatory biomarkers. It improved hematological and histopathological parameters, modulated cytokine expression, and showed promising phytochemical‐target interactions through GC–MS, network pharmacology, and ...
Sana Sabir, Aisha Mobashar, Hossam Kamli, Hafiza Mahnoor Baghdadi, Bushra Akhtar, Amir Ali, Sana Saleem, Khalid Hussain, Kiran Mashaal, Esmael M. Alyami, Mona Alsolami, Fakhreldeen Dabiellil, Pravin Badhe, Gehan M. Elossaily, Muhammad Shahab, Abdel‐Rhman Z. Gaafar   +15 more
wiley   +1 more source

DNA-Encoded Library Technology-Based Discovery, Lead Optimization, and Prodrug Strategy toward Structurally Unique Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors

, 2020
We report the discovery of a novel indoleamine 2,3-dioxygenase-1 (IDO1) inhibitor class through the affinity selection of a previously unreported indole-based DNA-encoded library (DEL).
Makda Mebrahtu (8599728), Yoshiaki Washio (1523548), Zhengrong Zhu (4637572), Jeffrey A. Messer (1438693), Ghotas Evindar (1370346), Bing Xia (76986), Wieslaw M. Kazmierski (1706686), Vicente Samano (1833607), Ninad Prabhu (8599737), Liping Wang (33601), Christopher Davie (8599740), David Favre (267195), Lijun Fan (2007628), Martha De la Rosa (8599722), Feng Wang (44414), Richard M. Dunham (8599725), Alison Olszewski (8599734), John Miller (14007), Hongfeng Deng (1438666), Jonathan Basilla (8599731)   +19 more
core   +1 more source

Divergent Clonal Trajectories of FLT3‐ITD in Acute Myeloid Leukemia and Their Clinical and Transcriptomic Associations

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT FLT3‐ITD occurs in approximately 20%–25% of cases of adult AML and is associated with increased relapse risk and shorter survival. FLT3‐ITD status informs AML risk at diagnosis, but its dynamic changes during disease evolution are not well defined.
Xavier Cheng‐Hong Tsai, Yu‐Sung Chang, Feng‐Ming Tien, Min‐Yen Lo, Yuan‐Yeh Kuo, Mei‐Hsuan Tseng, Yen‐Ling Peng, Chi‐Yuan Yao, Szu‐Chi Yao, Chien‐Chin Lin, Bor‐Sheng Ko, Ming Yao, Hwei‐Fang Tien, Hsin‐An Hou, Wen‐Chien Chou   +14 more
wiley   +1 more source

Artesunate induces melanoma cell ferroptosis and augments antitumor immunity through targeting Ido1

Cell Communication and Signaling
Artesunate (ART), a natural product isolated from traditional Chinese plant Artemisia annua, has not been extensively explored for its anti-melanoma properties.
Wuyi Liu, Huyue Zhou, Wenjing Lai, Changpeng Hu, Qiaoling Wang, Chengsha Yuan, Chunmei Luo, Mengmeng Yang, Min Hu, Rong Zhang, Guobing Li   +10 more
doaj   +1 more source

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

Unveiling the Role of Tryptophan 2,3-Dioxygenase in the Angiogenic Process

Pharmaceuticals
Background: Indoleamine 2,3-dioxygenase (IDO1) and tryptophan-2,3-dioxygenase (TDO) are the two principals enzymes involved in the catabolization of tryptophan (Trp) into kynurenine (Kyn).
Marta Cecchi, Cecilia Anceschi, Angela Silvano, Maria Luisa Coniglio, Aurora Chinnici, Lucia Magnelli, Andrea Lapucci, Anna Laurenzana, Astrid Parenti   +8 more
doaj   +1 more source

AT-0174, a novel dual IDO1/TDO2 enzyme inhibitor, synergises with temozolomide to improve survival in an orthotopic mouse model of glioblastoma

BMC Cancer
Glioblastoma is an aggressive brain cancer, usually of unknown etiology, and with a very poor prognosis. Survival from diagnosis averages only 3 months if left untreated and this only increases to 12–15 months upon treatment.
Michael J. Bickerdike, I. Nafia, A. Bessede, Cheng-Bang Chen, M. Wangpaichitr   +4 more
semanticscholar   +1 more source

Molecular Functions and Drug Prediction of MMP1 and TGFBR2 in Nasopharyngeal Carcinoma

Journal of Clinical Laboratory Analysis, Volume 40, Issue 18, September 2026.
MMP1 and TGFBR2 were validated by machine learning and external datasets as the candidate genes. Dexamethasone showed strong binding affinity to MMP1 (−7.72 kcal/mol) and TGFBR2 (−7.27 kcal/mol) in docking studies. Knockdown of MMP1 repressed the malignant phenotypes of NPC cells.
Feng Wang, Binbin Ge, Ming Li, Xiaochun Xia, Fuming Zhang, Pengqin Xu   +5 more
wiley   +1 more source