Results 101 to 110 of about 4,006,149 (207)

Pengaruh Lapachol dan β-Lapachone dalam Pohon Tabebuya Pink (Tabebuia Avellanedae) sebagai Inhibitor Protein IDO1 pada Penderita Oral Squamous Cell Carcinoma

, 2022
Salah satu jenis kanker rongga mulut yang sering terjadi dan ditemui dengan persentase 90% yaitu Oral Squamous Cell Carcinoma (OSCC). Penderita OSCC memiliki tingkat kelangsungan hidup hanya sebesar 50%. Pada OSCC terjadi peningkatan ekspresi proten IDO1
M. Biomed., Drg. Feni Istikharoh, Harjanto, Shania Helza   +1 more
core  

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy

OncoImmunology, 2020
CD40-stimulating immunotherapy can elicit potent anti-tumor responses by activating dendritic cells and enhancing T-cell priming. Tumor vessels orchestrate T-cell recruitment during immune response, but the effect of CD40-stimulating immunotherapy on ...
Maria Georganaki, Mohanraj Ramachandran, Sander Tuit, Nicolás Gonzalo Núñez, Alexandros Karampatzakis, Grammatiki Fotaki, Luuk van Hooren, Hua Huang, Roberta Lugano, Thomas Ulas, Aura Kaunisto, Eric C Holland, Peter Ellmark, Sara M Mangsbo, Joachim Schultze, Magnus Essand, Sonia Tugues, Anna Dimberg   +17 more
doaj   +1 more source

Metabolic reprogramming of the immune response in periodontitis

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon, Melissa Grant, Iain Chapple, Joao Paulo Steffens   +3 more
wiley   +1 more source

Crystal Structures and Structure–Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors

, 2016
Indoleamine 2,3-dioxygenase 1 (IDO1) is considered as a promising target for the treatment of several diseases, including neurological disorders and cancer.
Tomoyuki Tanaka (1738816), Tetsuya Kohno (1738807), Shigehiro Asano (1331397), Seiji Kamioka (1738804), Yosuke Ota (433924), Takayuki Ishii (1738813), Keiko Kamimoto (1738810), Yoshiaki Isobe (1721080), Shingo Tojo (1738819)   +8 more
core   +1 more source

Dietary tryptophan augments cancer-associated venous thrombogenicity mitigated by indoleamine 2,3-dioxygenase 1 inhibition

Blood Advances
: Studies related to cardio-oncology remain a high priority, considering that venous thromboembolism (VTE) in cancer survivors is the second most common cause of death.
Saran Lotfollahzadeh, Asha Jose, Xiaosheng Yang, Tanvi Bathla, Adam Lazowski, Isaac Hoekstra, Kashvi Sethuraman, Sowmya Potluri, Karlynn N Dulberger, Jennifer La, Nathanael R Fillmore, Maria Del Carmen Piqueras, Norman Lee, Howard Cabral, Katya Ravid, Vipul C. Chitalia   +15 more
doaj   +1 more source

Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas

OncoImmunology, 2017
Indoleamine 2,3-deoxygenase 1 (IDO1) induces immune tolerance in the tumor microenvironment (TME) and is recognized as a potential therapeutic target.
Pilvi Maliniemi, Kirsi Laukkanen, Liisa Väkevä, Katja Dettmer, Tuomas Lipsanen, Leila Jeskanen, Alban Bessede, Peter J. Oefner, Marshall E. Kadin, Annamari Ranki   +9 more
doaj   +1 more source

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Abstract 2618: Agonist antibodies targeting OX40 and GITR enhance the activity of the IDO1-selective inhibitor epacadostat in preclinical models

, 2017
The majority of immunotherapeutic agents developed thus far either attempt to stimulate a more productive anti-tumor immune response or to inhibit key proteins in the immunosuppressive tumor milieu.
Gregory Hollis, Thomas Condamine, Leslie Hall, Kerri Lasky, Horacio Nastri, Brendan Horton, Reid Huber, Liang-Chuan Wang, Michael Hansbury, Sybil O'Connor, Thomas Gajewski, Peggy Scherle, Holly K. Koblish, Christina Stevens, Yue Zhang   +14 more
core   +1 more source

Action mechanism and molecular design of indolepyrrodione inhibitors targeting IDO1

Frontiers in Molecular Biosciences
IntroductionThe incidence of cancer remains high, representing not only a major health threat to humanity but also a substantial economic burden to society.
Xinmin Wang, Zhigang Zhang, Kaixuan Hu, Wentong Yu, Yan Cheng, Yuting Song, Xin Sun, Siyao Li, Tiantian Yang, Jianping Hu, Jing Jing, Ting Luo   +11 more
doaj   +1 more source