Results 181 to 190 of about 4,006,149 (207)

Combination of apatinib with apo-IDO1 inhibitor for the treatment of colorectal cancer

International Immunopharmacology, 2022
Colorectal cancer (CRC) is the third most common cancer in the world. Recently, many clinical studies have demonstrated the therapeutic potential of immune checkpoint therapy combined with inhibitors of vascular endothelial growth factor receptor 2 ...
Long-Bo Yu, Yuan-Yuan Wang, Yi He, Haiqing Zhong, Shu-Shan Ge, Yi Zou, Yi-Sheng Lai, Qiang Xu, Jian Gao, Wen Liu, Wenjie Guo   +10 more
exaly   +2 more sources

Ginsenoside-Rg1 acts as an IDO1 inhibitor, protects against liver fibrosis via alleviating IDO1-mediated the inhibition of DCs maturation

Phytomedicine, 2021
BACKGROUND Indoleamine 2,3-dioxygenase 1 (IDO1) has been reported as a hallmark of hepatic fibrosis. Ginseng Rg1(G-Rg1) is a characterized bioactive component isolated from a traditional Chinese medicinal herb Panax ginseng C. A.
Zhiping Lv, Sha Huang
exaly   +2 more sources

Chiral resolution, absolute configuration determination, and stereo-activity relationship study of IDO1 inhibitor NLG919

Tetrahedron, 2018
NLG919 (1) with two chiral carbon atoms on its chemical structure is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. We developed an effective way to prepare all stereoisomers of 1, the key step being the chiral resolution of racemic ...

exaly   +2 more sources

Abstract 4964: Structure, in vitro biology and in vivo pharmacodynamic characterization of a novel clinical IDO1 inhibitor

, 2017
The enzyme indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the degradation of tryptophan along the kynurenine pathway, and is frequently expressed in human malignancies.
J. T. Hunt, A. Balog, Christine S. Huang, Tai-An Lin, D. Maley, J. Gullo-Brown, Jesse Swanson, Jennifer G Brown   +7 more
semanticscholar   +2 more sources

Mechanism Found for IDO1 Inhibitor Evasion.

Cancer Discovery, 2022
Researchers have pinpointed metabolic alterations that may allow tumors to evade the IDO1 inhibitor epacadostat. Tumor cells enlisted an alternative pathway to break down tryptophan, the target of IDO1, and increased the activity of pathways that ...

semanticscholar   +1 more source

Process Safety Considerations for the Supply of a High-Energy Oxadiazole IDO1-Selective Inhibitor

Organic Process Research and Development, 2019
The development of a stereospecific synthesis of a IDO1-selective inhibitor is described. The synthetic strategy toward enabling early discovery efforts along with additional findings pertaining to process safety that limited scalability are outlined.
Josep Sauri, Yu-Hong Lam, Michael Ardolino   +2 more
exaly   +2 more sources

PCC0208009, an indirect IDO1 inhibitor, alleviates neuropathic pain and co-morbidities by regulating synaptic plasticity of ACC and amygdala.

Biochemical Pharmacology, 2020
BACKGROUND AND PURPOSE Indoleamine 2, 3-dioxygenase 1 (IDO1) has been linked to neuropathic pain and IDO1 inhibitors have been shown to reduce pain in animals.
Yu Wang, Chun-Mei Li, Rui Han, Zhe-Zhe Wang, Yong-Lin Gao, Xiao-Yin Zhu, Xin Yu, Guang-Ying Du, Hong-Bo Wang, Jing-Wei Tian, F. Fu   +10 more
semanticscholar   +1 more source

Abstract CT116: BMS-986205, an optimized indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, is well tolerated with potent pharmacodynamic (PD) activity, alone and in combination with nivolumab (nivo) in advanced cancers in a phase 1/2a trial

, 2017
Background: IDO1 is highly expressed in multiple cancers and may be an immunosuppressive mechanism for tumor escape via its production of metabolites that inhibit T-cell function.
L. Siu, K. Gelmon, Q. Chu, R. Pachynski, O. Alese, P. Basciano, Walker Justine Kamilah, P. Mitra, Li Zhu, P. Phillips, J. T. Hunt, J. Desai   +11 more
semanticscholar   +2 more sources

Folated pH-degradable nanogels for the simultaneous delivery of docetaxel and an IDO1-inhibitor in enhancing cancer chemo-immunotherapy.

Biomaterials Science, 2019
Combining chemotherapy and immunotherapy has been considered as an attractive approach to improve cancer therapy. Here we prepared folated PVA-based nanogels for the simultaneous delivery of docetaxel (DTX) and the indoleamine 2,3-dioxygenase 1 (IDO1 ...
Hai-Shi Qiao, Xingmei Chen, E. Chen, Jun-Mei Zhang, Dechun Huang, Dan-bo Yang, You-Chao Ding, Hongliang Qian, J. Feijen, Wei Chen   +9 more
semanticscholar   +1 more source