Results 1 to 10 of about 310,962 (265)

Nutritional Regulation Of IGF-I And IGF Binding Proteins

Annual Review of Nutrition, 1991
"The insulin-like growth factors (IGF-I and IGF-II) are small polypeptides (Mr -7500) that control growth of multiple cell types. Cells derived from all three embryonic lineages contain IGF receptors, and almost all cell types have been shown to respond to IGFs (79).
David R. Clemmons
openalex   +5 more sources

The same but different: impact of animal facility sanitary status on a transgenic mouse model of Alzheimer’s disease [PDF]

mBio
The gut-brain axis has emerged as a key player in the regulation of brain function and cognitive health. Gut microbiota dysbiosis has been observed in preclinical models of Alzheimer’s disease and patients.
Caroline Ismeurt-Walmsley, Patrizia Giannoni, Florence Servant, Linda-Nora Mekki, Kevin Baranger, Santiago Rivera, Philippe Marin, Benjamin Lelouvier, Sylvie Claeysen   +8 more
doaj   +2 more sources

Transcriptional regulation of the IGF signaling pathway by amino acids and insulin-like growth factors during myogenesis in Atlantic salmon [PDF]

, 2010
The insulin-like growth factor signalling pathway is an important regulator of skeletal muscle growth. We examined the mRNA expression of components of the insulin-like growth factor (IGF) signalling pathway as well as Fibroblast Growth Factor 2 (FGF2 ...
A Amores, A Bardonnet, A Musaro, A Yamaguchi, B Felding-Habermann, B Motyka, C Boker, C Duan, C Duan, C Talbot, CEH Stewart, CH Chu, CH Clegg, CKI Smith, CM Duan, CM Duan, CM Weyman, D LeRoith, D Seurin, DD Sarbassov, Dhawan, DJ Macqueen, DR Clemmons, DR Clemmons, DZ Ewton, E Erbay, E Kim, EM Wilson, F Chauvigne, FW Allendorf, G Caraux, G Pintucci, G Spizz, Gianni Parise, GM Findlay, GR Adams, GS Bailey, HA Acosta-Jaquez, HB Schiller, HX Ren, HX Ren, I Seiliez, IA Johnston, Ian A. Johnston, J Vandesompele, J Zhou, JC Anthony, JC Engert, JC Gabillard, JI Jones, JI Jones, JI Jones, JTM Koumans, JX Kang, LA Bach, LS Mathews, MD Layne, ME Coleman, MY Li, N Montseratt, Neil I. Bower, NI Bower, NI Bower, NI Bower, O Jaillon, P Nicklin, PJ Atherton, PY Muller, RA Frost, S Giorgetti, S Kadri, S Rousse, SA Bustin, SA Coolican, SM Firth, T Nobukuni, T Shavlakadze, X Wang, Y Sancak   +78 more
core   +28 more sources

Whole-brain characterization of apoptosis after sevoflurane anesthesia reveals neuronal cell death patterns in the mouse neonatal neocortex

Scientific Reports, 2023
In the last two decades, safety concerns about general anesthesia (GA) arose from studies documenting brain cell death in various pharmacological conditions and animal models.
Julie Areias, Chrystelle Sola, Yan Chastagnier, Julien Pico, Nathalie Bouquier, Christophe Dadure, Julie Perroy, Vivien Szabo   +7 more
doaj   +1 more source

Effect of diabetes mellitus on levels of insulin-like growth factors and their carrier proteins in Guerin’s carcinoma and it’s perifocal tissue in rats

Исследования и практика в медицине, 2021
Purpose of the study. Diabetes mellitus (DM) is considered an independent risk factor for higher cancer incidence and death rates. The system of insulin-like growth factors and their carrier proteins (IGF and IGFBP) and hyperglycemia create favorable ...
E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, E. I. Surikova, I. V. Neskubina, Yu. A. Pogorelova, N. D. Cheryarina, P. S. Kachesova, L. A. Nemashkalova   +8 more
doaj   +1 more source

Structure, dynamics and transferability of the metal-dependent polyhistidine tetramerization motif TetrHis for single-chain Fv antibodies

Communications Chemistry, 2023
The polyhistidine (6XHis) motif is one of the most ubiquitous protein purification tags. The 6XHis motif enables the binding of tagged proteins to various metals, which can be advantageously used for purification with immobilized metal affinity ...
Robert D. Healey, Louise Couillaud, François Hoh, Assia Mouhand, Aurelien Fouillen, Pierre Couvineau, Sébastien Granier, Cédric Leyrat   +7 more
doaj   +1 more source

Disorders of IGFs and IGF-1R signaling pathways

Molecular and Cellular Endocrinology, 2020
The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that regulate multiple physiological processes, including mammalian development, metabolism and growth, through the type 1 IGF receptor (IGF-1R). The growth hormone (GH)-IGF-I axis is the major regulator of longitudinal growth.
Forbes, B.E., Blyth, A.J., Wit, J.M.
openaire   +4 more sources

Comparative analysis of transcriptome remodeling in plaque-associated and plaque-distant microglia during amyloid-β pathology progression in mice

Journal of Neuroinflammation, 2022
Background Research in recent years firmly established that microglial cells play an important role in the pathogenesis of Alzheimer's disease (AD).
Anne-Laure Hemonnot-Girard, Cédric Meersseman, Manuela Pastore, Valentin Garcia, Nathalie Linck, Catherine Rey, Amine Chebbi, Freddy Jeanneteau, Stephen D. Ginsberg, Joël Lachuer, Christelle Reynes, François Rassendren, Hélène Hirbec   +12 more
doaj   +1 more source

Violent suicide attempt history in elderly patients with bipolar disorder: The role of sex, abdominal obesity, and verbal memory: Results from the FACE-BD cohort (FondaMental Advanced center of Expertise for Bipolar Disorders) [PDF]

Journal of Affective Disorders, Elsevier, 2022, 296, pp.265-276, 2022
Background: Bipolar disorder (BD) is a chronic, lifelong condition, associated with increased risk of obesity, cognitive impairment, and suicidal behaviors. Abdominal obesity and a higher risk of violent suicide attempt (SA) seem to be shared correlates with older age, BD, and male sex until middle age when menopause-related female body changes occur ...
arxiv   +1 more source

FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell

Nature Communications, 2021
The demethylase FTO was shown to remove on N6-methyladenosine (m6A) and N6, 2’-O-dimethyladenosine (m6Am) modifications on RNAs. Here the authors show that FTO impedes cancer stem cell-like abilities in colorectal cancer cells through its m6Am ...
Sébastien Relier, Julie Ripoll, Hélène Guillorit, Amandine Amalric, Cyrinne Achour, Florence Boissière, Jérôme Vialaret, Aurore Attina, Françoise Debart, Armelle Choquet, Françoise Macari, Virginie Marchand, Yuri Motorin, Emmanuelle Samalin, Jean-Jacques Vasseur, Julie Pannequin, Francesca Aguilo, Evelyne Lopez-Crapez, Christophe Hirtz, Eric Rivals, Amandine Bastide, Alexandre David   +21 more
doaj   +1 more source