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New insights on the cardiovascular effects of IGF-1
Frontiers in Endocrinology, 2023 IntroductionCardiovascular (CV) disorders are steadily increasing, making them the world’s most prevalent health issue. New research highlights the importance of insulin-like growth factor 1 (IGF-1) for maintaining CV healthMethodsWe searched PubMed and ...
Mirjana Macvanin +7 more
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The IGF-1 Signaling Pathway in Viral Infections
Viruses, 2021 Insulin-like growth factor-1 (IGF-1) and the IGF-1 receptor (IGF-1R) belong to the insulin-like growth factor family, and IGF-1 activates intracellular signaling pathways by binding specifically to IGF-1R.
Agata Józefiak +3 more
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Insulin-Like Growth Factor-1 (IGF-1) and Its Monitoring in Medical Diagnostic and in Sports
Biomolecules, 2021 Insulin-like growth factor-1 (IGF-1) is the principal mediator of growth hormone (GH), plays a crucial role in promoting cell growth and differentiation in childhood and continues to have an anabolic effect in adults.
Julian Bailes, Mikhail Soloviev
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IGF-1 and IGF-1 SDS - fit for purpose? [PDF]
European Journal of Endocrinology, 2019 Three recent publications in this journal have reported that the differences in IGF-1 normative data significantly impact the classification of patients with growth hormone (GH)- excess and deficiency disorders in such a way that clinical performance is ...
S. Kos +7 more
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IGF-1 and cardiovascular disease. [PDF]
Growth Hormone & IGF Research, 2019 Atherosclerosis is an inflammatory arterial pathogenic condition, which leads to ischemic cardiovascular diseases, such as coronary artery disease and myocardial infarction, stroke, and peripheral arterial disease. Atherosclerosis is a multifactorial disorder and its pathophysiology is highly complex.
Y. Higashi +3 more
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Gut Microbiota and IGF-1 [PDF]
Calcified Tissue International, 2018 Microbiota and their hosts have coevolved for millions of years. Microbiota are not only critical for optimal development of the host under normal physiological growth, but also important to ensure proper host development during nutrient scarcity or disease conditions.
Jing Yan, J. Charles
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Haematologica, 2010 Background Alterations in the PI3K/Akt pathway are found in a wide range of cancers and the development of PI3K inhibitors represents a promising approach to cancer therapy.
Nicolas Chapuis +12 more
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Cells, 2020 Triple-negative breast cancer (TNBC) is an aggressive breast tumor subtype that currently lacks targeted treatment options. The role played by the insulin-like growth factor-1 (IGF-1) and its cognate receptor IGF-1R in TNBC has been reported ...
Damiano Cosimo Rigiracciolo +7 more
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Neuroprotection of IGF-1 in neonatal hypoxic-ischemic brain injury through downregulation of FoXO3a-PUMA pathway [PDF]
Frontiers in Cellular NeuroscienceInsulin-like growth factor-1 (IGF-1) is a single chain polypeptide hormone that plays an essential role in intrauterine and postnatal growth. Recent studies suggest that IGF-1 and its receptor IGF-1R are involved in the pathogenesis of neurological ...
Yanli Tang +12 more
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Is there a role for
Cancer Medicine, 2016 Cancer survival rates are increasing, and as a result, more cancer survivors are exposed to the risk of developing a second primary cancer (SPC). It has been hypothesized that one of the underlying mechanisms for this risk could be mediated by variations
Thurkaa Shanmugalingam +3 more
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