Results 11 to 20 of about 24,369,820 (336)
Scientific ReportsInsulin and insulin-like growth factor 1 (IGF-1) are metabolic hormones with known effects on CD4+ T cells through insulin receptor (IR) and IGF-1 receptor (IGF-1R) signaling. Here, we describe specific and distinct roles for these hormones and receptors.
Kaitlin Kiernan +4 more
doaj +2 more sources
Un viaggio nella Gestalt: come cambia il benessere durante il percorso gestaltico
Phenomena Journal, 2023 Questo lavoro riporta alcuni risultati preliminari di un progetto di ricerca volto a indagare il rapporto tra il benessere percepito e il lavoro personale in psicoterapia della Gestalt.
Stefano Roti 1 , Francesca Berti 1 , Nino Geniola2 , Susanna Zajotti 1 , Giulia Calvaresi 1 , Matteo Defraia1 , Alessandro Cini 1
doaj +1 more source
Research progress of IGF‐1 and cerebral ischemia
Ibrain, 2021 Cerebral ischemic disease is a group of diseases that cause insufficient blood supply to the cerebrum, cerebellum or brain stem for different reasons, resulting in corresponding nervous system symptoms.
Shun‐Lian Li +3 more
doaj +1 more source
Insulin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer
International Journal of Molecular Sciences, 2021 Colorectal cancer (CRC) is one of the most common aggressive carcinoma types worldwide, characterized by unfavorable curative effect and poor prognosis.
A. Kasprzak
semanticscholar +1 more source
Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets
Frontiers in Oncology, 2021 AimInsulin-like growth factor-1 receptor (IGF-1R) is one of the main members of the tyrosine protein kinase receptor family. This receptor binds insulin-like growth factor-1 (IGF-1) with a high affinity. IGF-1 is a member of a family of proteins involved
Yinqi Zhang +17 more
doaj +1 more source
Cells, 2021 In mammals, the neuroendocrine system, which includes the communication between the hypothalamus and the pituitary, plays a major role in controlling body growth and cellular metabolism. GH produced from the pituitary somatotroph is considered the master
Sarmed Al-Samerria, S. Radovick
semanticscholar +1 more source
Elevated serum concentrations of IGF-1 and IGF-1R in patients with thyroid cancers
Biomedical Papers, 2020 Background: The rising incidence of thyroid cancer observed in the last few decades requires an improvement in diagnostic tools and management techniques for patients with thyroid nodules. Aims: The aim of this study was to assess serum concentrations of
Hanna Lawnicka +7 more
doaj +1 more source
Inflammation Research, 2021 The insulin/IGF-1 signaling pathway has a major role in the regulation of longevity both in Caenorhabditis elegans and mammalian species, i.e., reduced activity of this pathway extends lifespan, whereas increased activity accelerates the aging process ...
A. Salminen +2 more
semanticscholar +1 more source
Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy
Cells, 2020 Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via PI3K/Akt/mTOR and PI3K/Akt/GSK3β pathways. PI3K/Akt can also inhibit
Tadashi Yoshida, P. Delafontaine
semanticscholar +1 more source
IGF-1 and IGFBP-3 in Inflammatory Cachexia
International Journal of Molecular Sciences, 2021 Inflammation induces a wide response of the neuroendocrine system, which leads to modifications in all the endocrine axes. The hypothalamic–growth hormone (GH)–insulin-like growth factor-1 (IGF-1) axis is deeply affected by inflammation, its response ...
A. Martín +5 more
semanticscholar +1 more source