Results 11 to 20 of about 147,857 (197)

IgA Enhances IGF-1 Mitogenic Activity Via Receptor Modulation in Glomerular Mesangial Cells: Implications for IgA-Induced Nephropathy

Kidney & Blood Pressure Research, 2017
Background/Aim: Glomerulonephritis due to mesangial proliferation is responsible for renal dysfunction in IgA nephropathy (IgAN), however molecular mechanisms of pathogenesis are not well known. We examined the effect of IgA on Insulin-like Growth Factor-
Amal Al-Eisa, Gursev S. Dhaunsi
doaj   +1 more source

Insulin-like growth factor-1 levels are associated with high comorbidity of metabolic disorders in obese subjects; a Japanese single-center, retrospective-study

Scientific Reports, 2022
Insulin like growth factor-1 (IGF-1) plays important roles in metabolic functions, especially in adulthood. Additionally, obese subjects are reportedly predisposed to having low absolute IGF-1 levels.
Haremaru Kubo, Shojiro Sawada, Michihiro Satoh, Yoichiro Asai, Shinjiro Kodama, Toshihiro Sato, Seitaro Tomiyama, Junro Seike, Kei Takahashi, Keizo Kaneko, Junta Imai, Hideki Katagiri   +11 more
doaj   +1 more source

Defects in mitophagy promote redox‐driven metabolic syndrome in the absence of TP53INP1

EMBO Molecular Medicine, 2015
The metabolic syndrome covers metabolic abnormalities including obesity and type 2 diabetes (T2D). T2D is characterized by insulin resistance resulting from both environmental and genetic factors.
Marion Seillier, Laurent Pouyet, Prudence N'Guessan, Marie Nollet, Florence Capo, Fabienne Guillaumond, Laure Peyta, Jean‐François Dumas, Annie Varrault, Gyslaine Bertrand, Stéphanie Bonnafous, Albert Tran, Gargi Meur, Piero Marchetti, Magalie A Ravier, Stéphane Dalle, Philippe Gual, Dany Muller, Guy A Rutter, Stéphane Servais, Juan L Iovanna, Alice Carrier   +21 more
doaj   +1 more source

Effects of In Ovo Vitamin D3 Injection on Subsequent Growth of Broilers

The Journal of Poultry Science, 2019
This study was conducted to investigate the influence of in ovo vitamin D3 (Vit D3) administration on growth of broiler chickens when Vit D3 was dissolved in soybean oil.
Takehiko Hayakawa, Jun-ichi Shiraishi, Yoshiyuki Ohta   +2 more
doaj   +1 more source

Insulin-like Growth Factor-1 (IGF-1) Related Drugs in Pain Management

Pharmaceuticals, 2023
Objective. The aim of this review is to explore the role of IGF-1 and IGF-1R inhibitors in pain-related conditions and assess the effectiveness of IGF-1-related drugs in pain management.
Seokhyun Jin, Jianguo Cheng
doaj   +1 more source

Research Note: Expression of IGF-1 and IGF-1 receptor proteins in skeletal muscle fiber types in chickens with hepatic fibrosis

Poultry Science, 2022
: We investigated the expression of insulin-like growth factor 1 (IGF-1) and IGF-1 type 1 receptor (IGF-1R) in skeletal muscle fiber types in chickens with hepatic fibrosis induced by bile duct ligation (BDL).
J. Nagasao, H. Fukasawa, K. Yoshioka, N. Fujimura, M. Kobayashi, Y. Tsunemi, A. Nomoto, S. Mitsui, H. Murata, I. Yokoyama, Y. Komiya, K. Arihara   +11 more
doaj   +1 more source

Doxorubicin impairs the insulin-like growth factor-1 system and causes insulin-like growth factor-1 resistance in cardiomyocytes. [PDF]

PLoS ONE, 2015
Insulin-like growth factor-1 (IGF-1) promotes the survival of cardiomyocytes by activating type 1 IGF receptor (IGF-1R). Within the myocardium, IGF-1 action is modulated by IGF binding protein-3 (IGFBP-3), which sequesters IGF-1 away from IGF-1R.
Patrizia Fabbi, Paolo Spallarossa, Silvano Garibaldi, Chiara Barisione, Marzia Mura, Paola Altieri, Barbara Rebesco, Maria Gaia Monti, Marco Canepa, Giorgio Ghigliotti, Claudio Brunelli, Pietro Ameri   +11 more
doaj   +1 more source

Insulin-Like Growth Factor-1 and Neuroinflammation

Frontiers in Aging Neuroscience, 2017
Insulin-like growth factor-1 (IGF-1) effects on aging and neurodegeneration is still controversial. However, it is widely admitted that IGF-1 is involved in the neuroinflammatory response.
Jose L. Labandeira-Garcia, Jose L. Labandeira-Garcia, Maria A. Costa-Besada, Maria A. Costa-Besada, Carmen M. Labandeira, Begoña Villar-Cheda, Begoña Villar-Cheda, Ana I. Rodríguez-Perez, Ana I. Rodríguez-Perez   +8 more
doaj   +1 more source

The Association between IGF-1 Polymorphisms, IGF-1 Serum Levels, and Cognitive Functions in Healthy Adults: The Amsterdam Growth and Health Longitudinal Study

International Journal of Endocrinology, 2014
Several studies have demonstrated an association between polymorphisms in the insulin-like growth factor-1 (IGF-1) gene and IGF-1 serum levels. IGF-1 levels have been associated with cognitive functioning in older persons and growth hormone deficient ...
Carmilla M. M. Licht, Lise C. van Turenhout, Jan Berend Deijen, Lando L. J. Koppes, Willem van Mechelen, Jos W. R. Twisk, Madeleine L. Drent   +6 more
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Initiation of muscle protein synthesis was unrelated to simultaneously upregulated local production of IGF-1 by amino acids in non-proliferating L6 muscle cells.

PLoS ONE, 2022
BackgroundIGF-1 is considered an important regulator of muscle protein synthesis. However, its role in stimulation of muscle protein synthesis by amino acids (AA) is not clear, despite pronounced alterations in IGF-1 mRNA expression and signaling in ...
Britt-Marie Iresjö, Lisa Diep, Kent Lundholm   +2 more
doaj   +1 more source