Results 21 to 30 of about 24,369,820 (336)

Genetic and dietary determinants of insulin-like growth factor (IGF)-1 and IGF binding protein (BP)-3 levels among Chinese women. [PDF]

PLoS ONE, 2014
BACKGROUND: Higher insulin-like growth factor (IGF)-1 and lower IGF binding protein (BP)-3 levels have been associated with higher commoncancer risk, including breast cancer.
Qiong Wang, Li Liu, Hui Li, Lauren E McCullough, Ya-na Qi, Jia-yuan Li, Jing Zhang, Erline Miller, Chun-xia Yang, Jennifer S Smith   +9 more
doaj   +1 more source

Aging, Atherosclerosis, and IGF-1 [PDF]

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2012
Insulin-like growth factor 1 (IGF-1) is an endocrine and autocrine/paracrine growth factor that circulates at high levels in the plasma and is expressed in most cell types. IGF-1 has major effects on development, cell growth and differentiation, and tissue repair. Recent evidence indicates that IGF-1 reduces atherosclerosis burden and improves features
Yusuke, Higashi, Sergiy, Sukhanov, Asif, Anwar, Shaw-Yung, Shai, Patrice, Delafontaine   +4 more
openaire   +2 more sources

Cyclic Glycine-Proline (cGP) Normalises Insulin-Like Growth Factor-1 (IGF-1) Function: Clinical Significance in the Ageing Brain and in Age-Related Neurological Conditions

Molecules, 2023
Insulin-like growth factor-1 (IGF-1) function declines with age and is associated with brain ageing and the progression of age-related neurological conditions.
Jian Guan, Fengxia Li, Dali Kang, Tim Anderson, Toni Pitcher, John Dalrymple-Alford, Paul Shorten, Gagandeep Singh-Mallah   +7 more
doaj   +1 more source

IgA Enhances IGF-1 Mitogenic Activity Via Receptor Modulation in Glomerular Mesangial Cells: Implications for IgA-Induced Nephropathy

Kidney & Blood Pressure Research, 2017
Background/Aim: Glomerulonephritis due to mesangial proliferation is responsible for renal dysfunction in IgA nephropathy (IgAN), however molecular mechanisms of pathogenesis are not well known. We examined the effect of IgA on Insulin-like Growth Factor-
Amal Al-Eisa, Gursev S. Dhaunsi
doaj   +1 more source

Insulin-like growth factor-1 levels are associated with high comorbidity of metabolic disorders in obese subjects; a Japanese single-center, retrospective-study

Scientific Reports, 2022
Insulin like growth factor-1 (IGF-1) plays important roles in metabolic functions, especially in adulthood. Additionally, obese subjects are reportedly predisposed to having low absolute IGF-1 levels.
Haremaru Kubo, Shojiro Sawada, Michihiro Satoh, Yoichiro Asai, Shinjiro Kodama, Toshihiro Sato, Seitaro Tomiyama, Junro Seike, Kei Takahashi, Keizo Kaneko, Junta Imai, Hideki Katagiri   +11 more
doaj   +1 more source

Defects in mitophagy promote redox‐driven metabolic syndrome in the absence of TP53INP1

EMBO Molecular Medicine, 2015
The metabolic syndrome covers metabolic abnormalities including obesity and type 2 diabetes (T2D). T2D is characterized by insulin resistance resulting from both environmental and genetic factors.
Marion Seillier, Laurent Pouyet, Prudence N'Guessan, Marie Nollet, Florence Capo, Fabienne Guillaumond, Laure Peyta, Jean‐François Dumas, Annie Varrault, Gyslaine Bertrand, Stéphanie Bonnafous, Albert Tran, Gargi Meur, Piero Marchetti, Magalie A Ravier, Stéphane Dalle, Philippe Gual, Dany Muller, Guy A Rutter, Stéphane Servais, Juan L Iovanna, Alice Carrier   +21 more
doaj   +1 more source

Effects of In Ovo Vitamin D3 Injection on Subsequent Growth of Broilers

The Journal of Poultry Science, 2019
This study was conducted to investigate the influence of in ovo vitamin D3 (Vit D3) administration on growth of broiler chickens when Vit D3 was dissolved in soybean oil.
Takehiko Hayakawa, Jun-ichi Shiraishi, Yoshiyuki Ohta   +2 more
doaj   +1 more source

IGF-1 receptor cleavage in hypertension [PDF]

Hypertension Research, 2018
Increased protease activity causes receptor dysfunction due to extracellular cleavage of different membrane receptors in hypertension. The vasodilatory effects of insulin-like growth factor-1 (IGF-1) are decreased in hypertension. Therefore, in the present study the association of an enhanced protease activity and IGF-1 receptor cleavage was ...
Cirrik, Selma, Schmid-Schönbein, Geert W   +1 more
openaire   +5 more sources

Insulin-like Growth Factor-1 (IGF-1) Related Drugs in Pain Management

Pharmaceuticals, 2023
Objective. The aim of this review is to explore the role of IGF-1 and IGF-1R inhibitors in pain-related conditions and assess the effectiveness of IGF-1-related drugs in pain management.
Seokhyun Jin, Jianguo Cheng
doaj   +1 more source

IGF-1 enhances BMSC viability, migration, and anti-apoptosis in myocardial infarction via secreted frizzled-related protein 2 pathway

Stem cell research & therapeutics, 2020
Bone marrow mesenchymal stem cell (BMSC) transplantation represents a promising therapeutic strategy for ischemic heart disease. However, its effects are hampered by the poor viability of transplanted cells and the hostile microenvironment of the ...
Mingzhuo Lin, Xinyue Liu, Haoxiao Zheng, Xiaohui Huang, Yu Wu, Anqing Huang, Hailan Zhu, Yunzhao Hu, W. Mai, Yuli Huang   +9 more
semanticscholar   +1 more source