Results 81 to 90 of about 24,369,820 (336)

Biohybrid Tendons Enhance the Power‐to‐Weight Ratio and Modularity of Muscle‐Powered Robots

Advanced Science, EarlyView.
Biohybrid robots powered by skeletal muscle actuators are capable of dynamically adapting to environmental cues. This study takes inspiration from native muscle–tendon architecture by leveraging tough hydrogels as synthetic tendons for muscle actuators to enhance the power‐to‐weight ratio and modularity of biohybrid machines.
Nicolas Castro, Ronald Heisser, Maheera Bawa, Bastien Aymon, Sarah Wu, Annika Marschner, Sonika Kohli, Angel Bu, Laura Rosado, Martin Culpepper, Xuanhe Zhao, Ritu Raman   +11 more
wiley   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Serum insulin-like growth factor-1 as a potential marker for MDD diagnosis, its clinical characteristics, and treatment efficacy validation: data from an open-label vortioxetine study

BMC Psychiatry, 2020
Background IGF-1 is an essential neurotrophin produced peripherally and in the brain. Impairments in the brain IGF-1 concentrations might be responsible for some aspects of major depressive disorder (MDD) pathogenesis, whereas peripheral IGF-1 could have
Oleg A. Levada, Alexandra S. Troyan, Irina Y. Pinchuk   +2 more
doaj   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Monocyte/Macrophage-derived IGF-1 Orchestrates Murine Skeletal Muscle Regeneration and Modulates Autocrine Polarization.

Molecular Therapy, 2015
Insulin-like growth factor 1 (IGF-1) is a potent enhancer of tissue regeneration, and its overexpression in muscle injury leads to hastened resolution of the inflammatory phase.
Joanne N Tonkin, L. Temmerman, R. Sampson, Enrique Gallego-Colon, L. Barberi, D. Bilbao, M. Schneider, A. Musarò, N. Rosenthal   +8 more
semanticscholar   +1 more source

Παθοφυσιολογία του μυοκαρδίου και βιορυθμιστικό σύστημα IGF-1/IGF-1-R [PDF]

, 2014
Ο ινσουλινομιμητικός αυξητικός παράγοντας-1 (IGF-1) εμπλέκεται στην αναδιαμόρφωση του μυοκαρδίου και την υπερτροφία. Δυο IGF-1 mRNA εναλλακτικά μετάγραφα έχουν ανιχνευτεί στα τρωκτικά (IGF-1Ea και MGF). Στη παρούσα διατριβή μελετήσαμε το πρότυπο έκφρασης των ισομορφών του IGF-1 και του υποδοχέα του (IGF-1R) σε διάφορα χρονικά σημεία κατά την διάρκεια ...
openaire   +1 more source

How IGF-1 activates its receptor

eLife, 2014
The type I insulin-like growth factor receptor (IGF1R) is involved in growth and survival of normal and neoplastic cells. A ligand-dependent conformational change is thought to regulate IGF1R activity, but the nature of this change is unclear. We point out an underappreciated dimer in the crystal structure of the related Insulin Receptor (IR) with ...
Jennifer M Kavran, Jacqueline M McCabe, Patrick O Byrne, Mary Katherine Connacher, Zhihong Wang, Alexander Ramek, Sarvenaz Sarabipour, Yibing Shan, David E Shaw, Kalina Hristova, Philip A Cole, Daniel J Leahy   +11 more
openaire   +3 more sources

GALNT10 Affects O‐Glycosylation of IGFBP7 to Promote Tumor Vascular Remodeling and Metastasis of Ovarian Cancer

Advanced Science, EarlyView.
The glycosyltransferase GALNT10 facilitates ovarian cancer metastasis through the induction of tumor cell EMT and tumor vascular dysfunction. GALNT10 enhanced the extracellular secretion of IGFBP7 through O‐GalNAc glycosylation modification at the T188 site, which subsequently interacts with CD93 on endothelial cells, leading to vascular remodeling ...
Yanan Zhang, Ayala Zuha, Zhangxin Wu, Aiping Luo, Bixia Jin, Qinkun Sun, Yuan Li, Qiyu Liu, Hongyan Guo, Chunliang Shang   +9 more
wiley   +1 more source

Effects of 2‐year calorie restriction on circulating levels of IGF‐1, IGF‐binding proteins and cortisol in nonobese men and women: a randomized clinical trial

Aging Cell, 2015
Young‐onset calorie restriction (CR) in rodents decreases serum IGF‐1 concentration and increases serum corticosterone levels, which have been hypothesized to play major roles in mediating its anticancer and anti‐aging effects.
L. Fontana, D. Villareal, S. Das, Steven R Smith, S. Meydani, A. Pittas, S. Klein, M. Bhapkar, J. Rochon, E. Ravussin, J. Holloszy   +10 more
semanticscholar   +1 more source

IGF-1: Analytik und Referenzbereiche / Measurement of IGF-1 and reference ranges

LaboratoriumsMedizin, 2008
Zusammenfassung Der Insulin-ähnliche Wachstumsfaktor IGF-1 (insulin-like growth factor 1) ist der ausschlaggebende Faktor zur Beurteilung des Wachstumshormonhaushalts. Da der IGF-1-Spiegel zahlreichen Einflüssen wie z. B. dem Alter, Geschlecht, genetischen Faktoren, der Ernährung oder Erkrankungen ausgesetzt ist, ist es notwendig, exakte
Elisabeth Spilcke-Liss, Nele Friedrich, Henri Wallaschofski   +2 more
openaire   +1 more source