Results 1 to 10 of about 101,239 (139)

Insulin receptor Arg717 and IGF-1 receptor Arg704 play a key role in ligand binding and in receptor activation [PDF]

Open Biology, 2023
The insulin receptor (IR, with its isoforms IR-A and IR-B) and the insulin-like growth factor 1 receptor (IGF-1R) are related tyrosine kinase receptors.
Anna Kertisová, Lenka Žáková, Kateřina Macháčková, Aleš Marek, Pavel Šácha, Petr Pompach, Jiří Jiráček, Irena Selicharová   +7 more
doaj   +2 more sources

How IGF-1 activates its receptor

eLife, 2014
The type I insulin-like growth factor receptor (IGF1R) is involved in growth and survival of normal and neoplastic cells. A ligand-dependent conformational change is thought to regulate IGF1R activity, but the nature of this change is unclear.
Jennifer M Kavran, Jacqueline M McCabe, Patrick O Byrne, Mary Katherine Connacher, Zhihong Wang, Alexander Ramek, Sarvenaz Sarabipour, Yibing Shan, David E Shaw, Kalina Hristova, Philip A Cole, Daniel J Leahy   +11 more
doaj   +3 more sources

Research Note: Expression of IGF-1 and IGF-1 receptor proteins in skeletal muscle fiber types in chickens with hepatic fibrosis [PDF]

Poultry Science, 2022
: We investigated the expression of insulin-like growth factor 1 (IGF-1) and IGF-1 type 1 receptor (IGF-1R) in skeletal muscle fiber types in chickens with hepatic fibrosis induced by bile duct ligation (BDL).
J. Nagasao, H. Fukasawa, K. Yoshioka, N. Fujimura, M. Kobayashi, Y. Tsunemi, A. Nomoto, S. Mitsui, H. Murata, I. Yokoyama, Y. Komiya, K. Arihara   +11 more
doaj   +2 more sources

Fluconazole Is Neuroprotective via Interactions with the IGF-1 Receptor. [PDF]

Neurotherapeutics, 2022
There is a continuing unmet medical need to develop neuroprotective strategies to treat neurodegenerative disorders. To address this need, we screened over 2000 compounds for potential neuroprotective activity in a model of oxidative stress and found that numerous antifungal agents were neuroprotective.
Toodle V, Lee MH, Bachani M, Ruffin A, Vivekanandhan S, Malik N, Wang T, Johnson TP, Nath A, Steiner JP.   +9 more
europepmc   +3 more sources

IGF-1 receptor cleavage in hypertension. [PDF]

Hypertens Res, 2018
Increased protease activity causes receptor dysfunction due to extracellular cleavage of different membrane receptors in hypertension. The vasodilatory effects of insulin-like growth factor-1 (IGF-1) are decreased in hypertension. Therefore, in the present study the association of an enhanced protease activity and IGF-1 receptor cleavage was ...
Cirrik S, Schmid-Schönbein GW.
europepmc   +7 more sources

Role of ubiquitination in IGF-1 receptor signaling and degradation. [PDF]

PLoS ONE, 2007
BACKGROUND: The insulin-like growth factor 1 receptor (IGF-1R) plays numerous crucial roles in cancer biology. The majority of knowledge on IGF-1R signaling is concerned with its role in the activation of the canonical phosphatidyl inositol-3 kinase ...
Bita Sehat, Sandra Andersson, Radu Vasilcanu, Leonard Girnita, Olle Larsson   +4 more
doaj   +4 more sources

A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression [PDF]

Molecular Metabolism
Objective: The insulin/IGF superfamily is conserved across vertebrates and invertebrates. Our team has identified five viruses containing genes encoding viral insulin/IGF-1 like peptides (VILPs) closely resembling human insulin and IGF-1. This study aims
Martina Chrudinová, Nicholas S. Kirk, Aurelien Chuard, Hari Venugopal, Fa Zhang, Marta Lubos, Vasily Gelfanov, Terezie Páníková, Lenka Žáková, Julianne Cutone, Matthew Mojares, Richard DiMarchi, Jiří Jiráček, Emrah Altindis   +13 more
doaj   +2 more sources

IGF-1 receptor antagonism inhibits autophagy [PDF]

Human Molecular Genetics, 2013
Inhibition of the insulin/insulin-like growth factor signalling pathway increases lifespan and protects against neurodegeneration in model organisms, and has been considered as a potential therapeutic target. This pathway is upstream of mTORC1, a negative regulator of autophagy.
Renna, Maurizio, Bento, Carla F., Fleming, Angeleen, Menzies, Fiona M., Siddiqi, Farah H., Ravikumar, Brinda, Puri, Claudia, Garcia-Arencibia, Moises, Sadiq, Oana, Corrochano, Silvia, Carter, Sarah, Brown, Steve D. M., Acevedo-Arozena, Abraham, Rubinsztein, David C.   +13 more
openaire   +5 more sources

IGF-IR internalizes with Caveolin-1 and PTRF/Cavin in HaCat cells. [PDF]

PLoS ONE, 2010
BACKGROUND:Insulin-like growth factor-I receptor (IGF-IR) is a tyrosine kinase receptor (RTK) associated with caveolae, invaginations of the plasma membrane that regulate vesicular transport, endocytosis and intracellular signaling.
Barbara Salani, Mario Passalacqua, Sara Maffioli, Lucia Briatore, Meriem Hamoudane, Paola Contini, Renzo Cordera, Davide Maggi   +7 more
doaj   +1 more source

Estrogen Receptor α Rapidly Activates the IGF-1 Receptor Pathway [PDF]

Journal of Biological Chemistry, 2000
Estrogen and insulin-like-growth factor 1 (IGF-1) are potent mitogenic stimuli that share important properties in the control of cellular proliferation. However, the coupling between the signaling cascades of estrogen receptors alpha and beta and the IGF-1 receptor (IGF-1R) is poorly understood.
S, Kahlert, S, Nuedling, M, van Eickels, H, Vetter, R, Meyer, C, Grohe   +5 more
openaire   +2 more sources