Results 11 to 20 of about 101,358 (257)
Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets
Frontiers in Oncology, 2021 AimInsulin-like growth factor-1 receptor (IGF-1R) is one of the main members of the tyrosine protein kinase receptor family. This receptor binds insulin-like growth factor-1 (IGF-1) with a high affinity. IGF-1 is a member of a family of proteins involved
Yinqi Zhang +17 more
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Pharmaceuticals, 2023 Pediatric high-grade gliomas (pHGG) accounts for approximately 8–12% of primary brain tumors in children. Prognosis is poor, with a median survival of 9–15 months. Insulin-like growth factor 1-receptor (IGF-1R) gene amplifications have been identified in
Yinhsuan Michely Chen +4 more
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International Journal of Biology, 2009 Thirty-six healthy and similar Chinese Merino sheep were selected and divided into six groups at random. Thetreatment group was injected intradermally with 0.5 mL IGF-1 (10ng/mL). Treatment skin tissue of sheep were sampledrespectively for 0,3,6,9,12 and 50 days and the skin expression of growth hormone receptor (GHR), insulin-like growthfactor1 (IGF-1)
Chengxian Zhang, Herong Liao, Yan Zhao
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The Insulin/IGF system in colorectal cancer development and resistance to therapy
Frontiers in Oncology, 2015 The Insulin/Insulin-like growth factor (IGF) system is a major determinant in the pathogenesis and progression of colorectal cancer (CRC). Indeed, several components of this signaling network including Insulin, IGF-1, IGF-2, the IGF-Binding Proteins, the
Paolo Giovanni Vigneri +6 more
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How IGF-1 activates its receptor [PDF]
Journal of Cell Communication and Signaling, 2015 This study presents a new model for IGF-I receptor activation in which the transmembrane domains are held apart until ligand binding brings them together in an activated state.
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Journal of Pharmacological Sciences, 2009 We previously demonstrated that the growth hormone (GH)-releaser diet ameliorated β-amyloid (Aβ) (1-42)–induced memory impairment, but the underlying mechanism remained to be characterized.
Eun-Joo Shin +7 more
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Polycystin-1 is required for insulin-like growth factor 1-induced cardiomyocyte hypertrophy.
PLoS ONE, 2021 Cardiac hypertrophy is the result of responses to various physiological or pathological stimuli. Recently, we showed that polycystin-1 participates in cardiomyocyte hypertrophy elicited by pressure overload and mechanical stress.
Carolina Fernández +10 more
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Kidney & Blood Pressure Research, 2017 Background/Aim: Glomerulonephritis due to mesangial proliferation is responsible for renal dysfunction in IgA nephropathy (IgAN), however molecular mechanisms of pathogenesis are not well known. We examined the effect of IgA on Insulin-like Growth Factor-
Amal Al-Eisa, Gursev S. Dhaunsi
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Conditional VHL gene deletion causes hypoglycemic death associated with disproportionately increased glucose uptake by hepatocytes through an upregulated IGF-I receptor. [PDF]
PLoS ONE, 2013 Our conditional VHL knockout (VHL-KO) mice, having VHL gene deletion induced by tamoxifen, developed severe hypoglycemia associated with disproportionately increased storage of PAS-positive substances in the liver and resulted in the death of these mice.
Atsushi Kurabayashi +5 more
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Human GH Receptor-IGF-1 Receptor Interaction: Implications for GH Signaling [PDF]
Molecular Endocrinology, 2014 GH signaling yields multiple anabolic and metabolic effects. GH binds the transmembrane GH receptor (GHR) to activate the intracellular GHR-associated tyrosine kinase, Janus kinase 2 (JAK2), and downstream signals, including signal transducer and activator of transcription 5 (STAT5) activation and IGF-1 gene expression.
Yujun, Gan +7 more
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