Results 21 to 30 of about 101,358 (257)

Understanding the mechanism of insulin and insulin-like growth factor (IGF) receptor activation by IGF-II. [PDF]

PLoS ONE, 2011
BACKGROUND: Insulin-like growth factor-II (IGF-II) promotes cell proliferation and survival and plays an important role in normal fetal development and placental function.
Clair L Alvino, Shee Chee Ong, Kerrie A McNeil, Carlie Delaine, Grant W Booker, John C Wallace, Briony E Forbes   +6 more
doaj   +1 more source

IGF-1 receptor regulates dynamic changes in neuronal polarity during cerebral cortical migration

Scientific Reports, 2017
During cortical development, neurons undergo polarization, oriented migration and layer-type differentiation. The biological and biochemical mechanisms underlying these processes are not completely understood.
Alvaro F. Nieto Guil, Mariana Oksdath, Linnea A. Weiss, Diego J. Grassi, Lucas J. Sosa, Marta Nieto, Santiago Quiroga   +6 more
doaj   +1 more source

Growth Hormone/Insulin Growth Factor Axis in Sex Steroid Associated Disorders and Related Cancers

Frontiers in Cell and Developmental Biology, 2021
To date, almost all solid malignancies have implicated insulin-like growth factor (IGF) signalling as a driver of tumour growth. However, the remarkable level of crosstalk between sex hormones, the IGF-1 receptor (IGF-1R) and its ligands IGF-1 and 2 in ...
Rachel Bleach, Mark Sherlock, Michael W. O’Reilly, Marie McIlroy   +3 more
doaj   +1 more source

Role of IGF-1 Receptor in Radiation Response

Translational Oncology, 2012
Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase involved in the development and progression of cancer whose activation strongly promotes cell growth and survival. IGF-1R exerts its main actions through the activation of the mitogen-activated protein kinase and phosphoinositide 3-kinase pathways. In addition to
Valenciano, Almudena, Henríquez-Hernández, Luis Alberto, Moreno, Mercedes, Lloret, Marta, Lara, Pedro Carlos   +4 more
openaire   +2 more sources

Effects of In Ovo Vitamin D3 Injection on Subsequent Growth of Broilers

The Journal of Poultry Science, 2019
This study was conducted to investigate the influence of in ovo vitamin D3 (Vit D3) administration on growth of broiler chickens when Vit D3 was dissolved in soybean oil.
Takehiko Hayakawa, Jun-ichi Shiraishi, Yoshiyuki Ohta   +2 more
doaj   +1 more source

IGF-1 Receptor Inhibitors in Clinical Trials—Early Lessons [PDF]

Journal of Mammary Gland Biology and Neoplasia, 2008
The insulin-like growth factor pathway plays a major role in cancer cell proliferation, survival and resistance to anti-cancer therapies in many human malignancies, including breast cancer. As a key signaling component of IGF system, the IGF-1 receptor is the target of several investigational agents in clinical and pre-clinical development. This review
S John, Weroha, Paul, Haluska
openaire   +2 more sources

The Role of Insulin and Insulin-like Growth Factors in the Increased Risk of Cancer in Diabetes

Rambam Maimonides Medical Journal, 2011
Patients with type 2 diabetes (T2D) are at increased risk of developing cancer. This evidence arises from numerous epidemiologic studies that relate a positive association between T2D and cancer. In-vitro and several in-vivo experiments have attempted to
Derek LeRoith, Eyal J. Scheinman, Keren Bitton-Worms   +2 more
doaj   +1 more source

Activation of Akt by advanced glycation end products (AGEs): involvement of IGF-1 receptor and caveolin-1. [PDF]

PLoS ONE, 2013
Diabetes is characterized by chronic hyperglycemia, which in turn facilitates the formation of advanced glycation end products (AGEs). AGEs activate signaling proteins such as Src, Akt and ERK1/2.
Su-Jung Yang, Chen-Yu Chen, Geen-Dong Chang, Hui-Chin Wen, Ching-Yu Chen, Shi-Chuan Chang, Jyh-Fei Liao, Chung-Ho Chang   +7 more
doaj   +1 more source

Initiation of muscle protein synthesis was unrelated to simultaneously upregulated local production of IGF-1 by amino acids in non-proliferating L6 muscle cells.

PLoS ONE, 2022
BackgroundIGF-1 is considered an important regulator of muscle protein synthesis. However, its role in stimulation of muscle protein synthesis by amino acids (AA) is not clear, despite pronounced alterations in IGF-1 mRNA expression and signaling in ...
Britt-Marie Iresjö, Lisa Diep, Kent Lundholm   +2 more
doaj   +1 more source

Insulin-like growth factor family and prostate cancer: new insights and emerging opportunities

Frontiers in Endocrinology
Prostate cancer is the second most commonly diagnosed cancer in men. The mammalian insulin-like growth factor (IGF) family is made up of three ligands (IGF-I, IGF-II, and insulin), three receptors (IGF-I receptor (IGF-1R), insulin receptor (IR), and IGF ...
Noha M. Elemam, Noha M. Elemam, Hassan Youssef Hotait, Mohamed A. Saleh, Mohamed A. Saleh, Mohamed A. Saleh, Waseem El-Huneidi, Waseem El-Huneidi, Iman M. Talaat, Iman M. Talaat, Iman M. Talaat   +10 more
doaj   +1 more source